The cutaneous microbiota as a determinant of skin barrier function

Molecular interactions and therapeutic opportunities

Julia J. Van Rensburg, Lana Dbeibo, Stanley Spinola

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

As the largest organ of the human body, skin provides the first barrier against environmental insults, including invading pathogens. Many studies have defined commensal skin bacteria; more recent metagenomic studies have extended characterization of the microbiota to resident fungi and viruses. The skin is dominated by members of Actinobacteria, Firmicutes, Proteobacteria, Bacteroidetes, Malassezia spp., bacteriophages and human viruses. Defining the microbiota of both healthy and affected skin provides insight into the influence of the cutaneous microbiota on immune responses and disease states. Crosstalk between commensal microbiota and the innate immune system facilitates proper response and healing. Commensal bacteria appear to protect from pathogens directly by releasing antibacterial products and indirectly by stimulating innate immune responses. Skin pathologies such as atopic dermatitis, rosacea, psoriasis and acne are characterized by disruptions of certain immune pathways and imbalances of skin microbiota. Additionally, susceptibility to skin infection appears to be influenced by the microbial community present on the skin, while infection and the resultant immune response alters the skin microbiota. Understanding the role of the skin microbiota in skin disorders and infection may lead to novel therapies that aim to restore the balance of commensal skin microbes.

Original languageEnglish (US)
Title of host publicationSkin Stress Response Pathways: Environmental Factors and Molecular Opportunities
PublisherSpringer International Publishing
Pages379-401
Number of pages23
ISBN (Electronic)9783319431574
ISBN (Print)9783319431550
DOIs
StatePublished - Jan 1 2016

Fingerprint

Microbiota
Skin
Therapeutics
Infection
Bacteroidetes
Malassezia
Viruses
Rosacea
Bacteria
Metagenomics
Proteobacteria
Actinobacteria
Immune System Diseases
Atopic Dermatitis
Human Body
Psoriasis
Innate Immunity
Bacteriophages
Immune System
Fungi

Keywords

  • Acne
  • Atopic dermatitis
  • Bacterial community
  • Infection
  • Microbiome
  • Psoriasis
  • Rosacea
  • Skin

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Van Rensburg, J. J., Dbeibo, L., & Spinola, S. (2016). The cutaneous microbiota as a determinant of skin barrier function: Molecular interactions and therapeutic opportunities. In Skin Stress Response Pathways: Environmental Factors and Molecular Opportunities (pp. 379-401). Springer International Publishing. https://doi.org/10.1007/978-3-319-43157-4_18

The cutaneous microbiota as a determinant of skin barrier function : Molecular interactions and therapeutic opportunities. / Van Rensburg, Julia J.; Dbeibo, Lana; Spinola, Stanley.

Skin Stress Response Pathways: Environmental Factors and Molecular Opportunities. Springer International Publishing, 2016. p. 379-401.

Research output: Chapter in Book/Report/Conference proceedingChapter

Van Rensburg, JJ, Dbeibo, L & Spinola, S 2016, The cutaneous microbiota as a determinant of skin barrier function: Molecular interactions and therapeutic opportunities. in Skin Stress Response Pathways: Environmental Factors and Molecular Opportunities. Springer International Publishing, pp. 379-401. https://doi.org/10.1007/978-3-319-43157-4_18
Van Rensburg JJ, Dbeibo L, Spinola S. The cutaneous microbiota as a determinant of skin barrier function: Molecular interactions and therapeutic opportunities. In Skin Stress Response Pathways: Environmental Factors and Molecular Opportunities. Springer International Publishing. 2016. p. 379-401 https://doi.org/10.1007/978-3-319-43157-4_18
Van Rensburg, Julia J. ; Dbeibo, Lana ; Spinola, Stanley. / The cutaneous microbiota as a determinant of skin barrier function : Molecular interactions and therapeutic opportunities. Skin Stress Response Pathways: Environmental Factors and Molecular Opportunities. Springer International Publishing, 2016. pp. 379-401
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