The detection and exclusion of the prostate Neuro-Vascular Bundle (NVB) in automated HIFU treatment planning using a pulsed-wave doppler ultrasound system

Wohsing Chen, Roy F. Carlson, Russell Fedewa, Ralf Seip, Narendra T. Sanghvi, Kris A. Dines, Richard Pfile, Michael A. Penna, Thomas A. Gardner

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Men with prostate cancer are likely to develop impotence after prostate cancer therapy if the treatment damages the neuro-vascular bundles (NVB). The NVB are generally located at the periphery of the prostate gland. To preserve the NVB, a Doppler system is used to detect and localize the associated blood vessels. This information is used during the therapy planning procedure to avoid treatment surrounding the blood vessel areas. The Sonablate®500 (Focus Surgery, Inc.) image-guided HIFU device is enhanced with a pulse-wave multi-gate Doppler system that uses the current imaging transducer and mechanical scanner to acquire Doppler data. Doppler detection is executed after the regular B-mode images are acquired from the base to the apex of the prostate using parallel sector scans. The results are stored and rendered in 3-D display, registered with additional models generated for the capsule, urethra, and rectal wall, and the B-mode data and treatment plan itself. The display of the blood flow can be in 2-D color overlaid on the B-mode image or in 3-D color structure. Based on this 3-D model, the HIFU treatment planning can be executed in automated or manual mode by the physician to remove originally defined treatment zones that overlap with the NVB (for preservation of NVB). The results of the NVB detection in animal experiments, and the 3-D modeling and data registration of the prostate will be presented.

Original languageEnglish (US)
Title of host publication4th International Symposium on Therapeutic Ultrasound
Pages23-26
Number of pages4
DOIs
StatePublished - Mar 28 2005
Event4th International Symposium on Therapeutic Ultrasound - Kyoto, Japan
Duration: Sep 18 2004Sep 20 2004

Publication series

NameAIP Conference Proceedings
Volume754
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Other

Other4th International Symposium on Therapeutic Ultrasound
CountryJapan
CityKyoto
Period9/18/049/20/04

ASJC Scopus subject areas

  • Physics and Astronomy(all)

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    Chen, W., Carlson, R. F., Fedewa, R., Seip, R., Sanghvi, N. T., Dines, K. A., Pfile, R., Penna, M. A., & Gardner, T. A. (2005). The detection and exclusion of the prostate Neuro-Vascular Bundle (NVB) in automated HIFU treatment planning using a pulsed-wave doppler ultrasound system. In 4th International Symposium on Therapeutic Ultrasound (pp. 23-26). (AIP Conference Proceedings; Vol. 754). https://doi.org/10.1063/1.1901590