The Determining Risk of Vascular Events by Apnea Monitoring (DREAM) study: design, rationale, and methods

Brian B. Koo, Christine Won, Bernardo J. Selim, Li Qin, Sangchoon Jeon, Nancy S. Redeker, Dawn M. Bravata, Kingman P. Strohl, John Concato, Andrey V. Zinchuk, Henry K. Yaggi

Research output: Contribution to journalArticle

4 Scopus citations


Purpose: The goal of the Determining Risk of Vascular Events by Apnea Monitoring (DREAM) study is to develop a prognostic model for cardiovascular outcomes, based on physiologic variables—related to breathing, sleep architecture, and oxygenation—measured during polysomnography in US veterans. Methods: The DREAM study is a multi-site, retrospective observational cohort study conducted at three Veterans Affairs (VA) centers (West Haven, CT; Indianapolis, IN; Cleveland, OH). Veterans undergoing polysomnography between January 1, 2000 and December 31, 2004 were included based on referral for evaluation of sleep-disordered breathing, documented history and physical prior to sleep testing, and ≥2-h sleep monitoring. Demographic, anthropomorphic, medical, medication, and social history factors were recorded. Measures to determine sleep apnea, sleep architecture, and oxygenation were recorded from polysomnography. VA Patient Treatment File, VA–Medicare Data, Vista Computerized Patient Record System, and VA Vital Status File were reviewed on dates subsequent to polysomnography, ranging from 0.06 to 8.8 years (5.5 ± 1.3 years; mean ± SD). Results: The study population includes 1840 predominantly male, middle-aged veterans. As designed, the main primary outcome is the composite endpoint of acute coronary syndrome, stroke, transient ischemic attack, or death. Secondary outcomes include incidents of neoplasm, congestive heart failure, cardiac arrhythmia, diabetes, depression, and post-traumatic stress disorder. Laboratory outcomes include measures of glycemic control, cholesterol, and kidney function. (Actual results are pending.) Conclusions: This manuscript provides the rationale for the inclusion of veterans in a study to determine the association between physiologic sleep measures and cardiovascular outcomes and specifically the development of a corresponding outcome-based prognostic model.

Original languageEnglish (US)
Pages (from-to)893-900
Number of pages8
JournalSleep and Breathing
Issue number2
StatePublished - May 1 2016


  • Cardiovascular
  • Epidemiology
  • OSA
  • Sleep apnea
  • Veterans

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Clinical Neurology

Fingerprint Dive into the research topics of 'The Determining Risk of Vascular Events by Apnea Monitoring (DREAM) study: design, rationale, and methods'. Together they form a unique fingerprint.

  • Cite this

    Koo, B. B., Won, C., Selim, B. J., Qin, L., Jeon, S., Redeker, N. S., Bravata, D. M., Strohl, K. P., Concato, J., Zinchuk, A. V., & Yaggi, H. K. (2016). The Determining Risk of Vascular Events by Apnea Monitoring (DREAM) study: design, rationale, and methods. Sleep and Breathing, 20(2), 893-900.