The development and in vivo function of T helper 9 cells

Mark Kaplan, Matthew M. Hufford, Matthew R. Olson

Research output: Contribution to journalArticle

151 Citations (Scopus)

Abstract

The specialized cytokine secretion profiles of T helper (T H) cells are the basis for a focused and efficient immune response. On the twentieth anniversary of the first descriptions of the cytokine signals that promote the differentiation of interleukin-9 (IL-9)-secreting T cells, this Review focuses on the extracellular signals and the transcription factors that promote the development of what we now term T H 9 cells, which are characterized by the production of this cytokine. We summarize our current understanding of the contribution of T H 9 cells to both effective immunity and immunopathological disease, and we propose that T H 9 cells could be targeted for the treatment of allergic and autoimmune disease.

Original languageEnglish
Pages (from-to)295-307
Number of pages13
JournalNature Reviews Immunology
Volume15
Issue number5
DOIs
StatePublished - Apr 24 2015

Fingerprint

Helper-Inducer T-Lymphocytes
Cytokines
Interleukin-9
Anniversaries and Special Events
Autoimmune Diseases
Immunity
Transcription Factors
T-Lymphocytes

ASJC Scopus subject areas

  • Immunology

Cite this

The development and in vivo function of T helper 9 cells. / Kaplan, Mark; Hufford, Matthew M.; Olson, Matthew R.

In: Nature Reviews Immunology, Vol. 15, No. 5, 24.04.2015, p. 295-307.

Research output: Contribution to journalArticle

Kaplan, Mark ; Hufford, Matthew M. ; Olson, Matthew R. / The development and in vivo function of T helper 9 cells. In: Nature Reviews Immunology. 2015 ; Vol. 15, No. 5. pp. 295-307.
@article{a539966d267a4e3594f7d6b24a3f5777,
title = "The development and in vivo function of T helper 9 cells",
abstract = "The specialized cytokine secretion profiles of T helper (T H) cells are the basis for a focused and efficient immune response. On the twentieth anniversary of the first descriptions of the cytokine signals that promote the differentiation of interleukin-9 (IL-9)-secreting T cells, this Review focuses on the extracellular signals and the transcription factors that promote the development of what we now term T H 9 cells, which are characterized by the production of this cytokine. We summarize our current understanding of the contribution of T H 9 cells to both effective immunity and immunopathological disease, and we propose that T H 9 cells could be targeted for the treatment of allergic and autoimmune disease.",
author = "Mark Kaplan and Hufford, {Matthew M.} and Olson, {Matthew R.}",
year = "2015",
month = "4",
day = "24",
doi = "10.1038/nri3824",
language = "English",
volume = "15",
pages = "295--307",
journal = "Nature Reviews Immunology",
issn = "1474-1733",
publisher = "Nature Publishing Group",
number = "5",

}

TY - JOUR

T1 - The development and in vivo function of T helper 9 cells

AU - Kaplan, Mark

AU - Hufford, Matthew M.

AU - Olson, Matthew R.

PY - 2015/4/24

Y1 - 2015/4/24

N2 - The specialized cytokine secretion profiles of T helper (T H) cells are the basis for a focused and efficient immune response. On the twentieth anniversary of the first descriptions of the cytokine signals that promote the differentiation of interleukin-9 (IL-9)-secreting T cells, this Review focuses on the extracellular signals and the transcription factors that promote the development of what we now term T H 9 cells, which are characterized by the production of this cytokine. We summarize our current understanding of the contribution of T H 9 cells to both effective immunity and immunopathological disease, and we propose that T H 9 cells could be targeted for the treatment of allergic and autoimmune disease.

AB - The specialized cytokine secretion profiles of T helper (T H) cells are the basis for a focused and efficient immune response. On the twentieth anniversary of the first descriptions of the cytokine signals that promote the differentiation of interleukin-9 (IL-9)-secreting T cells, this Review focuses on the extracellular signals and the transcription factors that promote the development of what we now term T H 9 cells, which are characterized by the production of this cytokine. We summarize our current understanding of the contribution of T H 9 cells to both effective immunity and immunopathological disease, and we propose that T H 9 cells could be targeted for the treatment of allergic and autoimmune disease.

UR - http://www.scopus.com/inward/record.url?scp=84928584195&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84928584195&partnerID=8YFLogxK

U2 - 10.1038/nri3824

DO - 10.1038/nri3824

M3 - Article

C2 - 25848755

AN - SCOPUS:84928584195

VL - 15

SP - 295

EP - 307

JO - Nature Reviews Immunology

JF - Nature Reviews Immunology

SN - 1474-1733

IS - 5

ER -