The Drosophila 18 wheeler is required for morphogenesis and has striking similarities to Toll

Elizabeth Eldon, Sandra Kooyer, Diana D'Evelyn, Molly Duman, Patrick Lawinger, Juan Botas, Hugo Bellen

Research output: Contribution to journalArticlepeer-review

111 Scopus citations


We have isolated and characterized a novel gene, named 18 wheeler (18w) for its unique segmental expression pattern in Drosophila embryos and expression in cells that migrate extensively. 18 wheeler transcripts accumulate in embryos in a pattern reminiscent of segment polarity genes. Mutations in 18w cause death during larval development and early adulthood. Escaping mutant adults often display leg, antenna, and wing deformities, presumably resulting from improper eversion of imaginal discs. Sequence analysis indicates that 18w encodes a transmembrane protein with an extracellular moiety containing many leucine rich repeats and cysteine motifs, and an intracellular domain bearing homology to the cytoplasmic portion of the interleukin-1-receptor. Expression of 18W protein in non-adhesive Schneider 2 cells promotes rapid and robust aggregation of cells. Analysis of the expression of 18w in different mutant backgrounds shows that it is under control of segment polarity and homeotic genes. The data suggest that the 18W protein participates in the developmental program specified by segmentation and homeotic genes as a cell ahesion or receptor molecule that facilitates cell movements.

Original languageEnglish (US)
Pages (from-to)885-899
Number of pages15
Issue number4
StatePublished - Apr 1 1994
Externally publishedYes


  • Homeotic genes
  • Interleukin-1-receptor
  • Leucine rich repeats
  • Morphogenesis
  • Segment polarity
  • Toll

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology

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