The dynamic role of cardiac fibroblasts in development and disease

Jacquelyn D. Lajiness, Simon Conway

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Cardiac fibroblasts are the most abundant cell in the mammalian heart. While they have been historically overlooked in terms of functional contributions to development and physiology, cardiac fibroblasts are now front and center. They are currently recognized as key protagonists during both normal development and cardiomyopathy disease, and work together with cardiomyocytes through paracrine, structural, and potentially electrical interactions. However, the lack of specific biomarkers and fibroblast heterogeneous nature currently convolutes the study of this dynamic cell lineage; though, efforts to advance marker analysis and lineage mapping technologies are ongoing. These tools will help elucidate the functional significance of fibroblast-cardiomyocyte interactions in vivo and delineate the dynamic nature of normal and pathological cardiac fibroblasts. Since therapeutic promise lies in understanding the interface between developmental biology and the postnatal injury response, future studies to understand the divergent roles played by cardiac fibroblasts both in utero and following cardiac insult are essential.

Original languageEnglish
Pages (from-to)739-748
Number of pages10
JournalJournal of Cardiovascular Translational Research
Volume5
Issue number6
DOIs
StatePublished - Dec 2012

Fingerprint

Fibroblasts
Cardiac Myocytes
Developmental Biology
Cell Lineage
Cardiomyopathies
Biomarkers
Technology
Wounds and Injuries
Therapeutics

Keywords

  • Cardiac fibroblast
  • Cardiomyocytes
  • Cardiomyopathy
  • Cell lineage marking
  • Embryo heart
  • Periostin

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Genetics
  • Genetics(clinical)
  • Molecular Medicine
  • Pharmaceutical Science

Cite this

The dynamic role of cardiac fibroblasts in development and disease. / Lajiness, Jacquelyn D.; Conway, Simon.

In: Journal of Cardiovascular Translational Research, Vol. 5, No. 6, 12.2012, p. 739-748.

Research output: Contribution to journalArticle

@article{eafeadb0e3bc4fd8b6c3a0e91cbbed69,
title = "The dynamic role of cardiac fibroblasts in development and disease",
abstract = "Cardiac fibroblasts are the most abundant cell in the mammalian heart. While they have been historically overlooked in terms of functional contributions to development and physiology, cardiac fibroblasts are now front and center. They are currently recognized as key protagonists during both normal development and cardiomyopathy disease, and work together with cardiomyocytes through paracrine, structural, and potentially electrical interactions. However, the lack of specific biomarkers and fibroblast heterogeneous nature currently convolutes the study of this dynamic cell lineage; though, efforts to advance marker analysis and lineage mapping technologies are ongoing. These tools will help elucidate the functional significance of fibroblast-cardiomyocyte interactions in vivo and delineate the dynamic nature of normal and pathological cardiac fibroblasts. Since therapeutic promise lies in understanding the interface between developmental biology and the postnatal injury response, future studies to understand the divergent roles played by cardiac fibroblasts both in utero and following cardiac insult are essential.",
keywords = "Cardiac fibroblast, Cardiomyocytes, Cardiomyopathy, Cell lineage marking, Embryo heart, Periostin",
author = "Lajiness, {Jacquelyn D.} and Simon Conway",
year = "2012",
month = "12",
doi = "10.1007/s12265-012-9394-3",
language = "English",
volume = "5",
pages = "739--748",
journal = "Journal of Cardiovascular Translational Research",
issn = "1937-5387",
publisher = "Springer New York",
number = "6",

}

TY - JOUR

T1 - The dynamic role of cardiac fibroblasts in development and disease

AU - Lajiness, Jacquelyn D.

AU - Conway, Simon

PY - 2012/12

Y1 - 2012/12

N2 - Cardiac fibroblasts are the most abundant cell in the mammalian heart. While they have been historically overlooked in terms of functional contributions to development and physiology, cardiac fibroblasts are now front and center. They are currently recognized as key protagonists during both normal development and cardiomyopathy disease, and work together with cardiomyocytes through paracrine, structural, and potentially electrical interactions. However, the lack of specific biomarkers and fibroblast heterogeneous nature currently convolutes the study of this dynamic cell lineage; though, efforts to advance marker analysis and lineage mapping technologies are ongoing. These tools will help elucidate the functional significance of fibroblast-cardiomyocyte interactions in vivo and delineate the dynamic nature of normal and pathological cardiac fibroblasts. Since therapeutic promise lies in understanding the interface between developmental biology and the postnatal injury response, future studies to understand the divergent roles played by cardiac fibroblasts both in utero and following cardiac insult are essential.

AB - Cardiac fibroblasts are the most abundant cell in the mammalian heart. While they have been historically overlooked in terms of functional contributions to development and physiology, cardiac fibroblasts are now front and center. They are currently recognized as key protagonists during both normal development and cardiomyopathy disease, and work together with cardiomyocytes through paracrine, structural, and potentially electrical interactions. However, the lack of specific biomarkers and fibroblast heterogeneous nature currently convolutes the study of this dynamic cell lineage; though, efforts to advance marker analysis and lineage mapping technologies are ongoing. These tools will help elucidate the functional significance of fibroblast-cardiomyocyte interactions in vivo and delineate the dynamic nature of normal and pathological cardiac fibroblasts. Since therapeutic promise lies in understanding the interface between developmental biology and the postnatal injury response, future studies to understand the divergent roles played by cardiac fibroblasts both in utero and following cardiac insult are essential.

KW - Cardiac fibroblast

KW - Cardiomyocytes

KW - Cardiomyopathy

KW - Cell lineage marking

KW - Embryo heart

KW - Periostin

UR - http://www.scopus.com/inward/record.url?scp=84878181963&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84878181963&partnerID=8YFLogxK

U2 - 10.1007/s12265-012-9394-3

DO - 10.1007/s12265-012-9394-3

M3 - Article

C2 - 22878976

AN - SCOPUS:84878181963

VL - 5

SP - 739

EP - 748

JO - Journal of Cardiovascular Translational Research

JF - Journal of Cardiovascular Translational Research

SN - 1937-5387

IS - 6

ER -