The dysfunctional endothelium in CKD and in cardiovascular disease: Mapping the origin(s) of cardiovascular problems in CKD and of kidney disease in cardiovascular conditions for a research agenda

Danilo Fliser, Andrzej Wiecek, Gultekin Suleymanlar, Alberto Ortiz, Ziad Massy, Bengt Lindholm, Alberto Martinez-Castelao, Rajiv Agarwal, Kitty J. Jager, Friedo W. Dekker, Peter J. Blankestijn, David Goldsmith, Adrian Covic, Gerard London, Carmine Zoccali

Research output: Contribution to journalReview article

35 Scopus citations

Abstract

Endothelial dysfunction resulting in disintegration of vascular structure and function is a key element in the progression of chronic kidney disease (CKD). Many risk factors-traditional and non-traditional-are thought to have a role in the progression and development of cardiovascular disease (CVD) in patients with CKD. However, many risk factors await definitive confirmation of their clinical relevance obtained from intervention trials. Moreover, the investigation of the relative contribution of these factors to the twin-risk problem of CVD and progression in patients with CKD is one of the most important future challenges for nephrologists.

Original languageEnglish (US)
Pages (from-to)6-9
Number of pages4
JournalKidney International Supplements
Volume1
Issue number1
DOIs
StatePublished - Jun 1 2011

Keywords

  • biomarkers
  • cardiovascular disease
  • chronic kidney disease
  • endothelium

ASJC Scopus subject areas

  • Nephrology

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    Fliser, D., Wiecek, A., Suleymanlar, G., Ortiz, A., Massy, Z., Lindholm, B., Martinez-Castelao, A., Agarwal, R., Jager, K. J., Dekker, F. W., Blankestijn, P. J., Goldsmith, D., Covic, A., London, G., & Zoccali, C. (2011). The dysfunctional endothelium in CKD and in cardiovascular disease: Mapping the origin(s) of cardiovascular problems in CKD and of kidney disease in cardiovascular conditions for a research agenda. Kidney International Supplements, 1(1), 6-9. https://doi.org/10.1038/kisup.2011.6