The ebola virus matrix protein penetrates into the plasma membrane

A key step in viral protein 40 (VP40) oligomerization and viral egress

Emmanuel Adu-Gyamfi, Smita P. Soni, Yi Xue, Michelle A. Digman, Enrico Gratton, Robert Stahelin

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Background: The Ebola virus matrix protein (VP40) regulates the plasma membrane assembly and egress of the Ebola virus. Results: The plasma membrane induces membrane penetration of the VP40 C-terminal domain. Conclusion: Membrane penetration by VP40 is important for VP40 cellular localization, oligomerization, and viral budding. Significance: A better understanding of VP40-membrane interactions will help us to understand Ebola virus assembly and budding.

Original languageEnglish
Pages (from-to)5779-5789
Number of pages11
JournalJournal of Biological Chemistry
Volume288
Issue number8
DOIs
StatePublished - Feb 22 2013

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Ebolavirus
Oligomerization
Viral Proteins
Cell membranes
Viral Matrix Proteins
Viruses
Cell Membrane
Virus Release
Virus Assembly
Proteins
Membranes
Protein C

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Cite this

The ebola virus matrix protein penetrates into the plasma membrane : A key step in viral protein 40 (VP40) oligomerization and viral egress. / Adu-Gyamfi, Emmanuel; Soni, Smita P.; Xue, Yi; Digman, Michelle A.; Gratton, Enrico; Stahelin, Robert.

In: Journal of Biological Chemistry, Vol. 288, No. 8, 22.02.2013, p. 5779-5789.

Research output: Contribution to journalArticle

Adu-Gyamfi, Emmanuel ; Soni, Smita P. ; Xue, Yi ; Digman, Michelle A. ; Gratton, Enrico ; Stahelin, Robert. / The ebola virus matrix protein penetrates into the plasma membrane : A key step in viral protein 40 (VP40) oligomerization and viral egress. In: Journal of Biological Chemistry. 2013 ; Vol. 288, No. 8. pp. 5779-5789.
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