The ebola virus matrix protein penetrates into the plasma membrane: A key step in viral protein 40 (VP40) oligomerization and viral egress

Emmanuel Adu-Gyamfi, Smita P. Soni, Yi Xue, Michelle A. Digman, Enrico Gratton, Robert V. Stahelin

Research output: Contribution to journalArticlepeer-review

52 Scopus citations

Abstract

Background: The Ebola virus matrix protein (VP40) regulates the plasma membrane assembly and egress of the Ebola virus. Results: The plasma membrane induces membrane penetration of the VP40 C-terminal domain. Conclusion: Membrane penetration by VP40 is important for VP40 cellular localization, oligomerization, and viral budding. Significance: A better understanding of VP40-membrane interactions will help us to understand Ebola virus assembly and budding.

Original languageEnglish (US)
Pages (from-to)5779-5789
Number of pages11
JournalJournal of Biological Chemistry
Volume288
Issue number8
DOIs
StatePublished - Feb 22 2013

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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