The effect of aminoglycosides on glomerular endothelium: a comparative study

F. C. Luft, G. R. Aronoff, A. P. Evan, B. A. Connors

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Abstract

In addition to being tubular nephrotoxins, the aminoglycosides are known to injure the glomerular endothelium by decreasing the diameter and density of endothelial fenestrae. To determine whether or not these changes correlate with the rank order of toxicity we compared in rats the effects of netilmicin, tobramycin, and amikacin on renal function, tubular and glomerular ultrastructure, at 10 and 25 times the recommended human dose. According to measurements of glomerular filtration rate their rank order of toxicity, in increasing severity was: netilmicin, tobramycin, and amikacin. The same order of effect was observed on glomerular ultrastructure. Thus glomerular structural changes correspond to glomerular functional changes in this model.

Original languageEnglish (US)
Pages (from-to)89-95
Number of pages7
JournalResearch Communications in Chemical Pathology and Pharmacology
Volume34
Issue number1
StatePublished - Dec 1 1981

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ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Toxicology
  • Pharmacology
  • Pharmacology, Toxicology and Pharmaceutics(all)

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