The effect of atrial natriuretic peptide on trout stomach motility

Jörgen Jensen, Kenneth R. Olson

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

The effect of atrial natriuretic peptide (ANP) was examined on longitudinal and circular smooth muscle of esophagus, stomach, anterior and posterior intestine, and longitudinal muscle of the pyloric ceca from the rainbow trout (Oncorhynchus mykiss). ANP had the greatest effect in longitudinal stomach (LS) where it reduced spontaneous rhythmical contractions and baseline tension in otherwise unstimulated strips. ANP relaxed LS precontracted with 10-6 M acetylcholine (ACh) in a dose-dependent manner (pD2 = 8.39 ± 0.07; N = 8). Pretreatment of LS with 10-6 M tetrodotoxin (TTX) did not affect the ability of ANP to relax ACh contractions (pD2 before TTX = 8.48 ± 0.09 versus 8.47 ± 0.06 after TTX; N = 7). ANP produced modest inhibitory effects in other longitudinal gastrointestinal (GI) smooth muscle, decreased the rate of, but did not inhibit, rhythmical activity in anterior intestine, and slightly increased tension of rhythmical contractions in esophageal and anterior intestine. ANP was virtually ineffective on all circular smooth muscle. It is concluded that, in addition to the well known direct effects of this peptide on GI absorption, ANP may affect GI function through regulation of motility.

Original languageEnglish (US)
Pages (from-to)273-277
Number of pages5
JournalComparative Biochemistry and Physiology -- Part A: Physiology
Volume108
Issue number2-3
DOIs
StatePublished - Jan 1 1994

Keywords

  • Atrial natriuretic peptide, ANP
  • Oncorhynchus mykiss
  • Stomach motility

ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Biochemistry

Fingerprint Dive into the research topics of 'The effect of atrial natriuretic peptide on trout stomach motility'. Together they form a unique fingerprint.

  • Cite this