The effect of cannabis use and gender on the visual steady state evoked potential

Patrick D. Skosnik, Giri P. Krishnan, Jenifer L. Vohs, Brian F. O'Donnell

Research output: Contribution to journalArticle

33 Scopus citations

Abstract

Objective: Cannabis use often induces subjective distortions of perception. However, little work has been done examining the electroencephalographic (EEG) correlates of early sensory processing in cannabis users. The present study therefore examined visual function in cannabis users as assessed via the steady state visual evoked potential. (SSVEP). Methods: SSVEPs were examined in current cannabis users (n=17; 59% male; mean age=23.2 (S.D.=5.3)) and drug-naive controls (n=16; 38% male; mean age=21.3 (S.D.=3.1)) to periodic photic stimulation presented at 18 and 25 Hz. The visual SSVEP was quantified via spectral power and the phase-locking factor (PLF) at each frequency of stimulation. The transient N160 event-related potential (ERP) was also evaluated at stimulus onset. Results: The results showed that for both frequencies, female subjects in general displayed larger visual SSVEPs. A significant gender X group interaction also occurred at 18 Hz of stimulation, and age of onset of cannabis use positively correlated with 18 Hz spectral power values. Finally, the transient N160 component was shown to be reduced in cannabis users, regardless of gender. Conclusions: The present study was the first to demonstrate altered visual SSVEPs in cannabis users, and extends previous research demonstrating increased steady state responses in female subjects. While decreased SSVEPs provide initial evidence of altered oscillatory properties in primary visual circuits, reduction of the transient N160 component suggests disruption of later-stage visual processing in cannabis users. Significance: These data provide evidence of cannabinoid modulation of sensory/perceptual function in the visual system, and indicates that cannabis use may affect the oscillatory properties of sensory cortical circuits.

Original languageEnglish (US)
Pages (from-to)144-156
Number of pages13
JournalClinical Neurophysiology
Volume117
Issue number1
DOIs
StatePublished - Jan 1 2006

Keywords

  • Cannabis
  • EEG
  • Neural Synchronization
  • Schizophrenia
  • Steady-state evoked potentials
  • Vision

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Sensory Systems
  • Physiology (medical)

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