Abstract
Objective Recently, IGF-1 secreted by fibroblasts has been shown to prevent development of squamous cell carcinoma of the sun-damaged skin. The purpose of this study is to see if skin rejuvenation regiments can increase the levels of IGF-1 secreted and thus prevent the development of squamous cell skin cancers. Methods 3 subjects were selected. Silicone cast and photos of right and left pre and post auricular sites were obtained. Each site underwent either a deep chemexfoliation, medium depth chemexfoliation or one of two novel antioxidant cream regiments. Subjects were followed for 3 months. Follow up silicone casts were obtained for surface profilometry. Biopsies of the treated regions and a control site were also obtained and sent for histological evaluations for IGF-1 levels. Results 2 out of 3 subjects showed improvement of skin wrinkles using the antioxidant regiments. Also, 2 out of the 3 subjects showed increase in IGF-1 levels using a strong antioxidant regiment. The sites treated with chemexfoliation showed decrease in IGF-1 levels when compared to control. Conclusion These results suggest that antioxidant creams used could protect the skin against squamous cell carcinoma while chemexfoliated skin can potentially be at a higher risk of developing squamous cell carcinoma.
| Original language | English |
|---|---|
| Journal | Laryngoscope |
| Volume | 121 |
| Issue number | SUPPL. 5 |
| DOIs | |
| State | Published - 2011 |
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ASJC Scopus subject areas
- Otorhinolaryngology
Cite this
The effect of chemexfoliation and anti-aging regiments on fibroblast expression of IGF-1 : A pilot Study. / Zandifar, Hootan; Lewis, Daina A.; Spandau, Dan; Beeson, Willian H.; Travers, Jeffrey.
In: Laryngoscope, Vol. 121, No. SUPPL. 5, 2011.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The effect of chemexfoliation and anti-aging regiments on fibroblast expression of IGF-1
T2 - A pilot Study
AU - Zandifar, Hootan
AU - Lewis, Daina A.
AU - Spandau, Dan
AU - Beeson, Willian H.
AU - Travers, Jeffrey
PY - 2011
Y1 - 2011
N2 - Objective Recently, IGF-1 secreted by fibroblasts has been shown to prevent development of squamous cell carcinoma of the sun-damaged skin. The purpose of this study is to see if skin rejuvenation regiments can increase the levels of IGF-1 secreted and thus prevent the development of squamous cell skin cancers. Methods 3 subjects were selected. Silicone cast and photos of right and left pre and post auricular sites were obtained. Each site underwent either a deep chemexfoliation, medium depth chemexfoliation or one of two novel antioxidant cream regiments. Subjects were followed for 3 months. Follow up silicone casts were obtained for surface profilometry. Biopsies of the treated regions and a control site were also obtained and sent for histological evaluations for IGF-1 levels. Results 2 out of 3 subjects showed improvement of skin wrinkles using the antioxidant regiments. Also, 2 out of the 3 subjects showed increase in IGF-1 levels using a strong antioxidant regiment. The sites treated with chemexfoliation showed decrease in IGF-1 levels when compared to control. Conclusion These results suggest that antioxidant creams used could protect the skin against squamous cell carcinoma while chemexfoliated skin can potentially be at a higher risk of developing squamous cell carcinoma.
AB - Objective Recently, IGF-1 secreted by fibroblasts has been shown to prevent development of squamous cell carcinoma of the sun-damaged skin. The purpose of this study is to see if skin rejuvenation regiments can increase the levels of IGF-1 secreted and thus prevent the development of squamous cell skin cancers. Methods 3 subjects were selected. Silicone cast and photos of right and left pre and post auricular sites were obtained. Each site underwent either a deep chemexfoliation, medium depth chemexfoliation or one of two novel antioxidant cream regiments. Subjects were followed for 3 months. Follow up silicone casts were obtained for surface profilometry. Biopsies of the treated regions and a control site were also obtained and sent for histological evaluations for IGF-1 levels. Results 2 out of 3 subjects showed improvement of skin wrinkles using the antioxidant regiments. Also, 2 out of the 3 subjects showed increase in IGF-1 levels using a strong antioxidant regiment. The sites treated with chemexfoliation showed decrease in IGF-1 levels when compared to control. Conclusion These results suggest that antioxidant creams used could protect the skin against squamous cell carcinoma while chemexfoliated skin can potentially be at a higher risk of developing squamous cell carcinoma.
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U2 - 10.1002/lary.22257
DO - 10.1002/lary.22257
M3 - Article
VL - 121
JO - Laryngoscope
JF - Laryngoscope
SN - 0023-852X
IS - SUPPL. 5
ER -