The effect of fluoride therapy on blood chemistry parameters in osteoporotic females

Richard Jackson, S. Kelly, T. Noblitt, W. Zhang, A. Dunipace, Y. Li, G. Stookey, Barry Katz, E. Brizendine, S. Farley, D. Baylink

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

To determine the potential adverse effects, if any, of long-term fluoride ingestion in humans, samples were collected from 25 adult females taking daily doses of fluoride (mean, 23 mg elemental F) for the treatment of osteoporosis and from 38 osteoporotic female controls. Patients in the fluoride group had been receiving therapy for approximately 18 months with a mean duration of 4.2 years and had serum fluoride values of at least 10 μmol/l. Laboratory analyses for fluoride were conducted on plasma, urine and drinking water samples collected from each panelist. Blood was also collected for blood chemistry analyses and plasma lymphocytes were examined for the frequency of sister chromatid exchange (SCE). Plasma and urine fluoride levels were significantly different between the two groups, while water fluoride was not, The SCE frequency, a measurement of potential genotoxicity, did not differ between the two groups. Of the blood chemistry parameters measured, albumin, alkaline phosphatase, sodium, chloride, the albumin/globulin (A/G) ratio, indirect bilirubin, lactate dehydrogenase (LDH), and γ-glutamyl transferase (GGT) were found to be significantly different between the two groups (P ≤ 0.05). However, none of the mean group values were outside stated normal ranges for any of these parameters. We conclude that the risk of developing adverse systemic effects from the ingestion of fluoride, at dosages and for a duration comparable with that of our panel, is minimal.

Original languageEnglish
Pages (from-to)13-23
Number of pages11
JournalBone and Mineral
Volume27
Issue number1
StatePublished - 1994

Fingerprint

Fluorides
Blood
Sister Chromatid Exchange
Therapeutics
Plasmas
Albumins
Eating
Urine
Lymphocytes
Globulins
Transferases
L-Lactate Dehydrogenase
Bilirubin
Sodium Chloride
Drinking Water
Osteoporosis
Alkaline Phosphatase
Reference Values
Water
Serum

Keywords

  • Fluoride
  • Genotoxicity
  • Osteoporosis
  • Pharmacology

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Surgery

Cite this

Jackson, R., Kelly, S., Noblitt, T., Zhang, W., Dunipace, A., Li, Y., ... Baylink, D. (1994). The effect of fluoride therapy on blood chemistry parameters in osteoporotic females. Bone and Mineral, 27(1), 13-23.

The effect of fluoride therapy on blood chemistry parameters in osteoporotic females. / Jackson, Richard; Kelly, S.; Noblitt, T.; Zhang, W.; Dunipace, A.; Li, Y.; Stookey, G.; Katz, Barry; Brizendine, E.; Farley, S.; Baylink, D.

In: Bone and Mineral, Vol. 27, No. 1, 1994, p. 13-23.

Research output: Contribution to journalArticle

Jackson, R, Kelly, S, Noblitt, T, Zhang, W, Dunipace, A, Li, Y, Stookey, G, Katz, B, Brizendine, E, Farley, S & Baylink, D 1994, 'The effect of fluoride therapy on blood chemistry parameters in osteoporotic females', Bone and Mineral, vol. 27, no. 1, pp. 13-23.
Jackson R, Kelly S, Noblitt T, Zhang W, Dunipace A, Li Y et al. The effect of fluoride therapy on blood chemistry parameters in osteoporotic females. Bone and Mineral. 1994;27(1):13-23.
Jackson, Richard ; Kelly, S. ; Noblitt, T. ; Zhang, W. ; Dunipace, A. ; Li, Y. ; Stookey, G. ; Katz, Barry ; Brizendine, E. ; Farley, S. ; Baylink, D. / The effect of fluoride therapy on blood chemistry parameters in osteoporotic females. In: Bone and Mineral. 1994 ; Vol. 27, No. 1. pp. 13-23.
@article{27831b9bc884457082ff6518e680275f,
title = "The effect of fluoride therapy on blood chemistry parameters in osteoporotic females",
abstract = "To determine the potential adverse effects, if any, of long-term fluoride ingestion in humans, samples were collected from 25 adult females taking daily doses of fluoride (mean, 23 mg elemental F) for the treatment of osteoporosis and from 38 osteoporotic female controls. Patients in the fluoride group had been receiving therapy for approximately 18 months with a mean duration of 4.2 years and had serum fluoride values of at least 10 μmol/l. Laboratory analyses for fluoride were conducted on plasma, urine and drinking water samples collected from each panelist. Blood was also collected for blood chemistry analyses and plasma lymphocytes were examined for the frequency of sister chromatid exchange (SCE). Plasma and urine fluoride levels were significantly different between the two groups, while water fluoride was not, The SCE frequency, a measurement of potential genotoxicity, did not differ between the two groups. Of the blood chemistry parameters measured, albumin, alkaline phosphatase, sodium, chloride, the albumin/globulin (A/G) ratio, indirect bilirubin, lactate dehydrogenase (LDH), and γ-glutamyl transferase (GGT) were found to be significantly different between the two groups (P ≤ 0.05). However, none of the mean group values were outside stated normal ranges for any of these parameters. We conclude that the risk of developing adverse systemic effects from the ingestion of fluoride, at dosages and for a duration comparable with that of our panel, is minimal.",
keywords = "Fluoride, Genotoxicity, Osteoporosis, Pharmacology",
author = "Richard Jackson and S. Kelly and T. Noblitt and W. Zhang and A. Dunipace and Y. Li and G. Stookey and Barry Katz and E. Brizendine and S. Farley and D. Baylink",
year = "1994",
language = "English",
volume = "27",
pages = "13--23",
journal = "Bone and Mineral",
issn = "0169-6009",
publisher = "Elsevier BV",
number = "1",

}

TY - JOUR

T1 - The effect of fluoride therapy on blood chemistry parameters in osteoporotic females

AU - Jackson, Richard

AU - Kelly, S.

AU - Noblitt, T.

AU - Zhang, W.

AU - Dunipace, A.

AU - Li, Y.

AU - Stookey, G.

AU - Katz, Barry

AU - Brizendine, E.

AU - Farley, S.

AU - Baylink, D.

PY - 1994

Y1 - 1994

N2 - To determine the potential adverse effects, if any, of long-term fluoride ingestion in humans, samples were collected from 25 adult females taking daily doses of fluoride (mean, 23 mg elemental F) for the treatment of osteoporosis and from 38 osteoporotic female controls. Patients in the fluoride group had been receiving therapy for approximately 18 months with a mean duration of 4.2 years and had serum fluoride values of at least 10 μmol/l. Laboratory analyses for fluoride were conducted on plasma, urine and drinking water samples collected from each panelist. Blood was also collected for blood chemistry analyses and plasma lymphocytes were examined for the frequency of sister chromatid exchange (SCE). Plasma and urine fluoride levels were significantly different between the two groups, while water fluoride was not, The SCE frequency, a measurement of potential genotoxicity, did not differ between the two groups. Of the blood chemistry parameters measured, albumin, alkaline phosphatase, sodium, chloride, the albumin/globulin (A/G) ratio, indirect bilirubin, lactate dehydrogenase (LDH), and γ-glutamyl transferase (GGT) were found to be significantly different between the two groups (P ≤ 0.05). However, none of the mean group values were outside stated normal ranges for any of these parameters. We conclude that the risk of developing adverse systemic effects from the ingestion of fluoride, at dosages and for a duration comparable with that of our panel, is minimal.

AB - To determine the potential adverse effects, if any, of long-term fluoride ingestion in humans, samples were collected from 25 adult females taking daily doses of fluoride (mean, 23 mg elemental F) for the treatment of osteoporosis and from 38 osteoporotic female controls. Patients in the fluoride group had been receiving therapy for approximately 18 months with a mean duration of 4.2 years and had serum fluoride values of at least 10 μmol/l. Laboratory analyses for fluoride were conducted on plasma, urine and drinking water samples collected from each panelist. Blood was also collected for blood chemistry analyses and plasma lymphocytes were examined for the frequency of sister chromatid exchange (SCE). Plasma and urine fluoride levels were significantly different between the two groups, while water fluoride was not, The SCE frequency, a measurement of potential genotoxicity, did not differ between the two groups. Of the blood chemistry parameters measured, albumin, alkaline phosphatase, sodium, chloride, the albumin/globulin (A/G) ratio, indirect bilirubin, lactate dehydrogenase (LDH), and γ-glutamyl transferase (GGT) were found to be significantly different between the two groups (P ≤ 0.05). However, none of the mean group values were outside stated normal ranges for any of these parameters. We conclude that the risk of developing adverse systemic effects from the ingestion of fluoride, at dosages and for a duration comparable with that of our panel, is minimal.

KW - Fluoride

KW - Genotoxicity

KW - Osteoporosis

KW - Pharmacology

UR - http://www.scopus.com/inward/record.url?scp=0028173195&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028173195&partnerID=8YFLogxK

M3 - Article

VL - 27

SP - 13

EP - 23

JO - Bone and Mineral

JF - Bone and Mineral

SN - 0169-6009

IS - 1

ER -