The effect of fluoride therapy on blood chemistry parameters in osteoporotic females

R. Jackson, S. Kelly, T. Noblitt, W. Zhang, A. Dunipace, Y. Li, G. Stookey, B. Katz, E. Brizendine, S. Farley, D. Baylink

Research output: Contribution to journalArticle

11 Scopus citations


To determine the potential adverse effects, if any, of long-term fluoride ingestion in humans, samples were collected from 25 adult females taking daily doses of fluoride (mean, 23 mg elemental F) for the treatment of osteoporosis and from 38 osteoporotic female controls. Patients in the fluoride group had been receiving therapy for approximately 18 months with a mean duration of 4.2 years and had serum fluoride values of at least 10 μmol/l. Laboratory analyses for fluoride were conducted on plasma, urine and drinking water samples collected from each panelist. Blood was also collected for blood chemistry analyses and plasma lymphocytes were examined for the frequency of sister chromatid exchange (SCE). Plasma and urine fluoride levels were significantly different between the two groups, while water fluoride was not, The SCE frequency, a measurement of potential genotoxicity, did not differ between the two groups. Of the blood chemistry parameters measured, albumin, alkaline phosphatase, sodium, chloride, the albumin/globulin (A/G) ratio, indirect bilirubin, lactate dehydrogenase (LDH), and γ-glutamyl transferase (GGT) were found to be significantly different between the two groups (P ≤ 0.05). However, none of the mean group values were outside stated normal ranges for any of these parameters. We conclude that the risk of developing adverse systemic effects from the ingestion of fluoride, at dosages and for a duration comparable with that of our panel, is minimal.

Original languageEnglish (US)
Pages (from-to)13-23
Number of pages11
JournalBone and Mineral
Issue number1
StatePublished - 1994


  • Fluoride
  • Genotoxicity
  • Osteoporosis
  • Pharmacology

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Surgery

Fingerprint Dive into the research topics of 'The effect of fluoride therapy on blood chemistry parameters in osteoporotic females'. Together they form a unique fingerprint.

  • Cite this

    Jackson, R., Kelly, S., Noblitt, T., Zhang, W., Dunipace, A., Li, Y., Stookey, G., Katz, B., Brizendine, E., Farley, S., & Baylink, D. (1994). The effect of fluoride therapy on blood chemistry parameters in osteoporotic females. Bone and Mineral, 27(1), 13-23.