The effect of intravenous magnesium administration on aortic, right atrial and coronary perfusion pressures during CPR in swine

Charles G. Brown, Robert F. Griffth, Daniel Neely, Jamie Hobson, Brian Miller

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Objective: To determine the effect of magnesium administration on aortic, right atrial and coronary perfusion pressure (CPP) during cardiopulmonary resuscitation (CPR). Design: Twelve swine weighing 23.2 ± 3.1 kg were instrumented for CPP, aortic systolic (AOSP) and aortic diastolic (AODP) pressures. Intervention: Ventricular fibrillation was induced and after 20 min of CPR the animals were allocated to receive epinephrine 0.2 mg/kg, or epinephrine 0.2 mg/kg plus magnesium 0.14 g/kg. Epinephrine was repeated every 5 min. Arterial blood gases were determined during normal sinus rhythm and prior to drug administration. Results: Pressures were recorded and averaged over four consecutive 5-min intervals following initial drug administration. AOSP, AODP and CPP were compared using an analysis of covariance. AOSP was statistically lower in the group receiving magnesium. There was a trend toward lower AODP and CPP in the group receiving magnesium as well. These statistical differences and trends were absent after adjusting for pressures during normal sinus rhythm and serum bicarbonate prior to drug administration. Conclusions: In this model of prolonged cardiac arrest, the administration of magnesium with epinephrine appeared to have a negative effect on aortic pressures during CPR. Further study is needed to determine the confounding effect of serum bicarbonate on the response to epinephrine and magnesium during CPR.

Original languageEnglish (US)
Pages (from-to)3-12
Number of pages10
JournalResuscitation
Volume26
Issue number1
DOIs
StatePublished - 1993
Externally publishedYes

Fingerprint

Cardiopulmonary Resuscitation
Intravenous Administration
Magnesium
Swine
Perfusion
Epinephrine
Pressure
Bicarbonates
Arterial Pressure
Pharmaceutical Preparations
Blood Pressure
Ventricular Fibrillation
Heart Arrest
Serum
Gases

Keywords

  • Cardiac arrest
  • Epinephrine
  • Magnesium

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Nursing(all)

Cite this

The effect of intravenous magnesium administration on aortic, right atrial and coronary perfusion pressures during CPR in swine. / Brown, Charles G.; Griffth, Robert F.; Neely, Daniel; Hobson, Jamie; Miller, Brian.

In: Resuscitation, Vol. 26, No. 1, 1993, p. 3-12.

Research output: Contribution to journalArticle

Brown, Charles G. ; Griffth, Robert F. ; Neely, Daniel ; Hobson, Jamie ; Miller, Brian. / The effect of intravenous magnesium administration on aortic, right atrial and coronary perfusion pressures during CPR in swine. In: Resuscitation. 1993 ; Vol. 26, No. 1. pp. 3-12.
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