The effect of latanoprost on ocular blood flow

Alon Harris, Hanna J. Garzozi, Lynne McCranor, Ehud Rechtman, Chi Wah Yung, Brent Siesky

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Purpose: To investigate the effect of latanoprost on ocular hemodynamics in healthy subjects. Methods: In a randomized, double-masked, placebo-controlled crossover study, 12 healthy subjects received either placebo or latanoprost for 4 weeks in one randomly chosen eye. Following a 4-week washout period, each patient received the opposite treatment. Blood pressure, heart rate, logMar visual acuity, contrast sensitivity, iris photography, intraocular pressure (IOP), Heidelberg retinal flowmetry, and color Doppler imaging measurements were taken at baseline and post-treatment. Heidelberg retinal flowmetry images were analyzed using the pixel-by-pixel analysis. Color Doppler imaging measurements included peak systolic velocity and end diastolic velocities (cm/s), and the calculated resistance index. Pre- and post-treatment values were compared by Wilcoxon signed rank tests (P < 0.05 was considered to be statistically significant). Results: There were no significant changes in heart rate, blood pressure, contrast sensitivity, or visual acuity with either treatment. Latanoprost demonstrated a significant reduction in both IOP (P = 0.005) and retinal blood flow at the 10th (P = 0.009) and 25th (P = 0.009) percentiles of Heidelberg retinal flowmetry measurements in the superior temporal region. Latanoprost, however, did not reduce blood flow in the inferior temporal region and did not significantly elevate the percentage of zero-flow pixels of the temporal peripapillary area. Conclusion: Latanoprost has mostly neutral effects on ocular circulation. These findings must be investigated in glaucoma patients who may respond differently than healthy subjects due to faulty vascular autoregulation.

Original languageEnglish
Pages (from-to)19-26
Number of pages8
JournalInternational Ophthalmology
Volume29
Issue number1
DOIs
StatePublished - 2009

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latanoprost
Rheology
Healthy Volunteers
Contrast Sensitivity
Temporal Lobe
Intraocular Pressure
Visual Acuity
Color
Heart Rate
Placebos
Blood Pressure
Therapeutics
Photography
Iris
Nonparametric Statistics
Glaucoma
Cross-Over Studies
Blood Vessels
Homeostasis
Hemodynamics

Keywords

  • HRF
  • Latanoprost
  • Ocular blood flow

ASJC Scopus subject areas

  • Ophthalmology

Cite this

The effect of latanoprost on ocular blood flow. / Harris, Alon; Garzozi, Hanna J.; McCranor, Lynne; Rechtman, Ehud; Yung, Chi Wah; Siesky, Brent.

In: International Ophthalmology, Vol. 29, No. 1, 2009, p. 19-26.

Research output: Contribution to journalArticle

Harris, Alon ; Garzozi, Hanna J. ; McCranor, Lynne ; Rechtman, Ehud ; Yung, Chi Wah ; Siesky, Brent. / The effect of latanoprost on ocular blood flow. In: International Ophthalmology. 2009 ; Vol. 29, No. 1. pp. 19-26.
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