The effect of Mitomycin-C on Molteno implant surgery

L. B. Cantor, S. Sanders, V. Bhavnani, J. Hoop, A. Dobler, A. Harris, D. WuDunn

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Purpose: To assess the effect of adjunctive Mitomycin-C (MMC) in patients undergoing Molteno tube shunt implantation. Methods: 25 eyes of 25 consecutive patients undergoing Molteno implantation were assigned to receive either MMC 0.4 mg/cc in both superior quadrants or a control solution (BSS) in a prospective randomized masked study. Intraocular pressure, vision, and any complications were recorded at 1 week, and 1, 3, 6, and 12 months postoperatively. A 2-sample t-test was used to compare the difference and percent change at each follow-up visit. ANOVA was used to test overall drug effect. Results: 13 eyes received BSS and 12 eyes received MMC. There were no differences noted between the two groups on age or entry IOP. There was no difference between the two groups when comparing the mean difference in IOP from pre-op except at 1 week. There were no differences in complications between the groups. The mean percent decrease in IOP for each group relative to base-line is presented below: 1 wk 1 m 3 m 6 m 1 y BSS 69 44 38 42 73 MMC 87 56 45 46 70 P-Value 0.01 0.33 0.68 0.82 0.86. Conclusion: MMC did not have a significant effect on Molteno implant surgery. Either a different dose of MMC or a different antimetabolite strategy may be necessary to improve the pressure lowering effects of Molteno implantation.

Original languageEnglish (US)
Pages (from-to)S255
JournalInvestigative Ophthalmology and Visual Science
Issue number3
StatePublished - Feb 15 1996

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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