The effect of muscle fatigue on in vivo tibial strains

Charles Milgrom, Denitsa R. Radeva-Petrova, Aharon Finestone, Meir Nyska, Stephen Mendelson, Nisim Benjuya, Ariel Simkin, David Burr

Research output: Contribution to journalArticle

68 Citations (Scopus)

Abstract

Stress fracture is a common musculoskeletal problem affecting athletes and soldiers. Repetitive high bone strains and strain rates are considered to be its etiology. The strain level necessary to cause fatigue failure of bone ex vivo is higher than the strains recorded in humans during vigorous physical activity. We hypothesized that during fatiguing exercises, bone strains may increase and reach levels exceeding those measured in the non-fatigued state. To test this hypothesis, we measured in vivo tibial strains, the maximum gastrocnemius isokinetic torque and ground reaction forces in four subjects before and after two fatiguing levels of exercise: a 2 km run and a 30 km desert march. Strains were measured using strain-gauged staples inserted percutaneously in the medial aspect of their mid-tibial diaphysis. There was a decrease in the peak gastrocnemius isokinetic torque of all four subjects' post-march as compared to pre-run (p=0.0001), indicating the presence of gastrocnemius muscle fatigue. Tension strains increased 26% post-run (p=0.002, 95 % confidence interval (CI) and 29% post-march (p=0.0002, 95% CI) as compared to the pre-run phase. Tension strain rates increased 13% post-run (p=0.001, 95% CI) and 11% post-march (p=0.009, 95% CI) and the compression strain rates increased 9% post-run (p=0.0004, 95% CI) and 17% post-march (p=0.0001, 95% CI). The fatigue state increases bone strains well above those recorded in rested individuals and may be a major factor in the stress fracture etiology.

Original languageEnglish
Pages (from-to)845-850
Number of pages6
JournalJournal of Biomechanics
Volume40
Issue number4
DOIs
StatePublished - 2007

Fingerprint

Muscle Fatigue
Muscle
Fatigue of materials
Confidence Intervals
Bone and Bones
Stress Fractures
Bone
Torque
Exercise
Fatigue
Strain rate
Diaphyses
Military Personnel
Athletes
Skeletal Muscle

Keywords

  • Human
  • In vivo
  • Muscle fatigue
  • Stress fracture
  • Tibial bone strains

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine

Cite this

Milgrom, C., Radeva-Petrova, D. R., Finestone, A., Nyska, M., Mendelson, S., Benjuya, N., ... Burr, D. (2007). The effect of muscle fatigue on in vivo tibial strains. Journal of Biomechanics, 40(4), 845-850. https://doi.org/10.1016/j.jbiomech.2006.03.006

The effect of muscle fatigue on in vivo tibial strains. / Milgrom, Charles; Radeva-Petrova, Denitsa R.; Finestone, Aharon; Nyska, Meir; Mendelson, Stephen; Benjuya, Nisim; Simkin, Ariel; Burr, David.

In: Journal of Biomechanics, Vol. 40, No. 4, 2007, p. 845-850.

Research output: Contribution to journalArticle

Milgrom, C, Radeva-Petrova, DR, Finestone, A, Nyska, M, Mendelson, S, Benjuya, N, Simkin, A & Burr, D 2007, 'The effect of muscle fatigue on in vivo tibial strains', Journal of Biomechanics, vol. 40, no. 4, pp. 845-850. https://doi.org/10.1016/j.jbiomech.2006.03.006
Milgrom C, Radeva-Petrova DR, Finestone A, Nyska M, Mendelson S, Benjuya N et al. The effect of muscle fatigue on in vivo tibial strains. Journal of Biomechanics. 2007;40(4):845-850. https://doi.org/10.1016/j.jbiomech.2006.03.006
Milgrom, Charles ; Radeva-Petrova, Denitsa R. ; Finestone, Aharon ; Nyska, Meir ; Mendelson, Stephen ; Benjuya, Nisim ; Simkin, Ariel ; Burr, David. / The effect of muscle fatigue on in vivo tibial strains. In: Journal of Biomechanics. 2007 ; Vol. 40, No. 4. pp. 845-850.
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abstract = "Stress fracture is a common musculoskeletal problem affecting athletes and soldiers. Repetitive high bone strains and strain rates are considered to be its etiology. The strain level necessary to cause fatigue failure of bone ex vivo is higher than the strains recorded in humans during vigorous physical activity. We hypothesized that during fatiguing exercises, bone strains may increase and reach levels exceeding those measured in the non-fatigued state. To test this hypothesis, we measured in vivo tibial strains, the maximum gastrocnemius isokinetic torque and ground reaction forces in four subjects before and after two fatiguing levels of exercise: a 2 km run and a 30 km desert march. Strains were measured using strain-gauged staples inserted percutaneously in the medial aspect of their mid-tibial diaphysis. There was a decrease in the peak gastrocnemius isokinetic torque of all four subjects' post-march as compared to pre-run (p=0.0001), indicating the presence of gastrocnemius muscle fatigue. Tension strains increased 26{\%} post-run (p=0.002, 95 {\%} confidence interval (CI) and 29{\%} post-march (p=0.0002, 95{\%} CI) as compared to the pre-run phase. Tension strain rates increased 13{\%} post-run (p=0.001, 95{\%} CI) and 11{\%} post-march (p=0.009, 95{\%} CI) and the compression strain rates increased 9{\%} post-run (p=0.0004, 95{\%} CI) and 17{\%} post-march (p=0.0001, 95{\%} CI). The fatigue state increases bone strains well above those recorded in rested individuals and may be a major factor in the stress fracture etiology.",
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N2 - Stress fracture is a common musculoskeletal problem affecting athletes and soldiers. Repetitive high bone strains and strain rates are considered to be its etiology. The strain level necessary to cause fatigue failure of bone ex vivo is higher than the strains recorded in humans during vigorous physical activity. We hypothesized that during fatiguing exercises, bone strains may increase and reach levels exceeding those measured in the non-fatigued state. To test this hypothesis, we measured in vivo tibial strains, the maximum gastrocnemius isokinetic torque and ground reaction forces in four subjects before and after two fatiguing levels of exercise: a 2 km run and a 30 km desert march. Strains were measured using strain-gauged staples inserted percutaneously in the medial aspect of their mid-tibial diaphysis. There was a decrease in the peak gastrocnemius isokinetic torque of all four subjects' post-march as compared to pre-run (p=0.0001), indicating the presence of gastrocnemius muscle fatigue. Tension strains increased 26% post-run (p=0.002, 95 % confidence interval (CI) and 29% post-march (p=0.0002, 95% CI) as compared to the pre-run phase. Tension strain rates increased 13% post-run (p=0.001, 95% CI) and 11% post-march (p=0.009, 95% CI) and the compression strain rates increased 9% post-run (p=0.0004, 95% CI) and 17% post-march (p=0.0001, 95% CI). The fatigue state increases bone strains well above those recorded in rested individuals and may be a major factor in the stress fracture etiology.

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