The effect of neoadjuvant chemotherapy and surgery in children with malignant germ cell tumors of the genital region: A pediatric intergroup trial

Frederick Rescorla, Deborah Billmire, Charles Vinocur, Paul Colombani, Wendy London, Roger Giller, Barbara Cushing, Stephen Lauer, John Cullen, Mary Davis, Edith Hawkins

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

Purpose: This study was designed to evaluate (1) the efficacy of standard or high-dose cisplatin with etoposide and bleomycin and (2) the role of surgical resection in infants and children with malignant germ cell tumors (MGCT) of the genital region. Methods: Fourteen of 317 children enrolled in to the Pediatric Oncology Group/Children's Cancer Group intergroup study of MGCT from 1990 through 1996 had genital tumors. Thirteen were eligible for inclusion (12 vaginal, one penile). The initial procedure was biopsy in 11 and subtotal resection in 2. Patients were assigned randomly to receive 4 cycles of etoposide, bleomycin, and either standard or high-dose cisplatin. Results: Nine children underwent postchemotherapy excision of the residual site, and 2 had subsequent biopsies to confirm a complete response. Two with relapse were saved with additional therapy, and one with progressive disease died. The 4-year event-free survival rate in these patients is 76.2% ± 13.1%, and 4-year survival rate is 91.7% ± 8.4%. Conclusions: The author conclude that: (1) the current survival rate for genital MGCT is excellent, (2) delayed surgical resection with organ preservation is not associated with an adverse outcome, and (3) the treatment comparison of the effect of cisplatin dose was inconclusive in this small study population.

Original languageEnglish (US)
Pages (from-to)910-912
Number of pages3
JournalJournal of pediatric surgery
Volume38
Issue number6
DOIs
StatePublished - Jun 1 2003

Keywords

  • Genital tumors
  • Germ cell tumors

ASJC Scopus subject areas

  • Surgery

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    Rescorla, F., Billmire, D., Vinocur, C., Colombani, P., London, W., Giller, R., Cushing, B., Lauer, S., Cullen, J., Davis, M., & Hawkins, E. (2003). The effect of neoadjuvant chemotherapy and surgery in children with malignant germ cell tumors of the genital region: A pediatric intergroup trial. Journal of pediatric surgery, 38(6), 910-912. https://doi.org/10.1016/S0022-3468(03)00121-0