The effect of sildenafil on ocular blood flow

A. Harris, L. Kagemann, R. Ehrlich, Y. Ehrlich, C. R. López, V. A. Purvin

Research output: Contribution to journalReview article

41 Scopus citations


Sildenafil is a potent phosphodiesterase (PDE) 5 inhibitor that is used for patients with erectile dysfunction. Sildenafil induces vasodilation in selected smooth muscle via increased levels of guanosine 3′, 5′ cyclic monophosphate and increase in nitric oxide. The vasodilatory effects of the PDE 5 inhibitors led us to review its effect on the ocular vasculature. Sildenafil appears to increase blood flow velocity significantly in the retrobulbar and choroidal circulation. Most studies suggest an increase in choroidal blood flow, with a lesser effect on the retinal vasculature.

Original languageEnglish (US)
Pages (from-to)469-473
Number of pages5
JournalBritish Journal of Ophthalmology
Issue number4
StatePublished - Apr 2008

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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    Harris, A., Kagemann, L., Ehrlich, R., Ehrlich, Y., López, C. R., & Purvin, V. A. (2008). The effect of sildenafil on ocular blood flow. British Journal of Ophthalmology, 92(4), 469-473.