The effect of speed-of-processing training on depressive symptoms in ACTIVE

Fredric D. Wolinsky, Mark W. Vander Weg, Rene Martin, Frederick W. Unverzagt, Karlene K. Ball, Richard N. Jones, Sharon L. Tennstedt

Research output: Contribution to journalArticle

62 Scopus citations

Abstract

Objective. We evaluated the effects of three cognitive training interventions on depressive symptoms at 1 and 5 years. Methods. Advanced Cognitive Training for Independent and Vital Elderly is a multisite randomized controlled trial (age ≥ 65 years), with four groups (memory, reasoning, speed-of-processing, and no-contact control). Complete data were available for 2,014 (72%) and 1,516 (54%) of 2,802 participants at 1 and 5 years. Separate propensity score models adjusted for potential attrition bias. Clinically important increases in depressive symptoms were defined as: (a) Center for Epidemiological Studies-Depression scale (CES-D)-12 score increases ≥ 0.5 SD and (b) CES-D-12 score increases ≥ 1.0 SD. Multivariable logistic regression was used. Results. The speed-of-processing group (vs the no-contact control group) was 30% less likely to experience clinically important increases in depressive symptoms at 1-year (adjusted odds ratio [AOR] = 0.700, p =.012) and 5-year (AOR = 0.698, p =.023) posttraining for the ≥ 0.5 SD threshold. Similar results (AOR =.669 with p =.039 at 1 year; AOR = 0.651 with p =.059 at 5 years) were obtained for the ≥ 1.0 SD threshold. No differences were observed among the control, memory, or reasoning groups at either time period or at either threshold. Conclusion. The speed-of-processing intervention reduced the risk of clinically important increases in depressive symptoms at 1- and 5-years postbaseline.

Original languageEnglish (US)
Pages (from-to)468-472
Number of pages5
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume64
Issue number4
DOIs
StatePublished - Apr 1 2009

Keywords

  • Cognitive training
  • Depression
  • Randomized controlled trial
  • Speed-of-processing

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology
  • Medicine(all)

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