Objective: To determine tne effect of relatively low strontium concentrations on enamel rem- ineralization and investigate the dose-response effects of strontium and fluoride combina- tions on the remineralization of artificial caries lesions in vitro. Method and Materials i Artificial caries lesions were created in 135 bovine enamel specimens. Lesion severity was analyzed using transverse microradiography (TMR) and quantitative light-induced fluores- cence (QLF). The specimens were randomly assigned to nine treatment groups based on lesion volume after lesion creation, as measured by TMR. Treatment groups were based on a 3 X 3 factorial design (0/0.05/0.1 ppm fluoride and 0/10/15 ppm strontium). Lesions were re mineralized at 37°C for 14 days in artificial saliva, which was supplemented or not with NaF and/or SrCI2, X 6H2O. Lesion remineralization was assessed using QLF and TMR. Data were analyzed using ANOVA. Results: For the TMR data, lesion rsmineratization in the 10 ppm strontium + 0.05 ppm fluoride group was significantly higher than in all other groups (P < .05) except the 0 ppm strontium + 0.O5 ppm fluoride group (P= .06). The 10 ppm strontium + 0 ppm fluoride group exhibited significantly less remineralization than the 0 ppm strontium + 0 ppm fluoride group (P= .048). For the QLF data, intergroup differences were not the same as for the TMR analysis. The QLF measurement was only moderately correlat- ed with TMR mineral loss (r = -0.37) Conclusion: Strontium alone did not improve the rem- ineralization of artificial caries lesions under the chosen in vitro conditions. However, a synergistic effect between the combination of fluoride and strontium was found at specific concentrations.
|Original language||English (US)|
|State||Published - Jan 1 2012|
- Bovine teeth
- Dental caries
ASJC Scopus subject areas