The effect of strontium and combinations of strontium and fluoride on the remineralization of artificial caries lesions in vitro

Ghaeth H. Yassen, Frank Lippert, George Eckert, Jennifer Eder, Andrea Ferreirá Zandona

Research output: Contribution to journalArticle

5 Scopus citations


Objective: To determine tne effect of relatively low strontium concentrations on enamel rem- ineralization and investigate the dose-response effects of strontium and fluoride combina- tions on the remineralization of artificial caries lesions in vitro. Method and Materials i Artificial caries lesions were created in 135 bovine enamel specimens. Lesion severity was analyzed using transverse microradiography (TMR) and quantitative light-induced fluores- cence (QLF). The specimens were randomly assigned to nine treatment groups based on lesion volume after lesion creation, as measured by TMR. Treatment groups were based on a 3 X 3 factorial design (0/0.05/0.1 ppm fluoride and 0/10/15 ppm strontium). Lesions were re mineralized at 37°C for 14 days in artificial saliva, which was supplemented or not with NaF and/or SrCI2, X 6H2O. Lesion remineralization was assessed using QLF and TMR. Data were analyzed using ANOVA. Results: For the TMR data, lesion rsmineratization in the 10 ppm strontium + 0.05 ppm fluoride group was significantly higher than in all other groups (P < .05) except the 0 ppm strontium + 0.O5 ppm fluoride group (P= .06). The 10 ppm strontium + 0 ppm fluoride group exhibited significantly less remineralization than the 0 ppm strontium + 0 ppm fluoride group (P= .048). For the QLF data, intergroup differences were not the same as for the TMR analysis. The QLF measurement was only moderately correlat- ed with TMR mineral loss (r = -0.37) Conclusion: Strontium alone did not improve the rem- ineralization of artificial caries lesions under the chosen in vitro conditions. However, a synergistic effect between the combination of fluoride and strontium was found at specific concentrations.

Original languageEnglish (US)
Pages (from-to)e95-e103
JournalQuintessence international
Issue number7
StatePublished - Jan 1 2012



  • Bovine teeth
  • Dental caries
  • Enamel
  • Fluoride
  • Remineralization
  • Strontium

ASJC Scopus subject areas

  • Dentistry(all)

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