The effects of a salicylate, ibuprofen, and naproxen on the disposition of methotrexate in patients with rheumatoid arthritis

T. S. Tracy, K. Krohn, D. R. Jones, J. D. Bradley, S. D. Hall, D. C. Brater

Research output: Contribution to journalArticle

102 Scopus citations

Abstract

We have studied the pharmacokinetics of methotrexate in patients with rheumatoid arthritis concurrently treated with choline magnesium trisalicylate, ibuprofen, naproxen, or a non-NSAID analgesic (control treatment). The apparent systemic clearance of methotrexate was significantly reduced by all three treatments. Trisalicylate and ibuprofen both significantly reduced methotrexate renal clearance, but only the trisalicylate significantly displaced methotrexate from protein, increasing the fraction unbound by 28%. These data show that NSAIDs can affect the disposition of methotrexate, possibly increasing the potential for toxicity and necessitating dosage adjustments. However, large inter-subject variability precludes specific dosage recommendations.

Original languageEnglish (US)
Pages (from-to)121-125
Number of pages5
JournalEuropean Journal of Clinical Pharmacology
Volume42
Issue number2
DOIs
StatePublished - Feb 1 1992

Keywords

  • adverse effects
  • disposition
  • interaction
  • Methotrexate
  • non-steroidal anti-inflammatory drugs (NSAIDs)
  • pharmacokinetics

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Pharmacology (medical)

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