The effects of altered strain environments on bone tissue kinetics

D. B. Burr, M. B. Schaffler, K. H. Yang, D. D. Wu, M. Lukoschek, D. Kandzari, N. Sivaneri, J. D. Blaha, E. L. Radin

Research output: Contribution to journalArticle

74 Scopus citations

Abstract

This study defines the alteration in bone tissue kinetics responsible for the "adaptive remodeling" response to altered strain environments. Adult beagle dogs were separated into three experimental groups: ulnar osteotomy, ulnar osteotomy with fracture fixation plate spanning the gap and sham surgery. Four sets of double fluorochrome labels were administered. Prior to sacrifice at 1, 3, and 6 months, strains were measured through rosette strain gages on the cranial and caudal surfaces of the intact radius. Histomorphometric analysis indicated that the increased bone mass in response to elevated strain results from increased activation frequency of modeling with more sites undergoing formation processes than resorption processes on periosteal and endocortical surfaces. Increased remodeling activation did not lead to increased bone mass. There was no evidence that elevated strain changes the individual vigor of osteoclasts or osteoblasts, or that the sigma period was altered by elevated strain.

Original languageEnglish (US)
Pages (from-to)215-221
Number of pages7
JournalBone
Volume10
Issue number3
DOIs
StatePublished - 1989

Keywords

  • Bone kinetics
  • Dogs
  • Remodeling
  • Strain

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Physiology
  • Histology

Fingerprint Dive into the research topics of 'The effects of altered strain environments on bone tissue kinetics'. Together they form a unique fingerprint.

  • Cite this

    Burr, D. B., Schaffler, M. B., Yang, K. H., Wu, D. D., Lukoschek, M., Kandzari, D., Sivaneri, N., Blaha, J. D., & Radin, E. L. (1989). The effects of altered strain environments on bone tissue kinetics. Bone, 10(3), 215-221. https://doi.org/10.1016/8756-3282(89)90056-2