The effects of antioxidants on ocular blood flow in patients with glaucoma

Alon Harris, Josh Gross, Nicholas Moore, Thai Do, Amelia Huang, Willy Gama, Brent Siesky

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Purpose: To investigate the effects of an antioxidant dietary supplement that includes Ginkgo biloba, on retinal and retrobulbar blood flow in patients with open-angle glaucoma (OAG). Methods: Forty-five patients with confirmed OAG were enroled in a randomized, double blinded, placebo-controlled cross-over study. Baseline and postadministration measurements of intraocular pressure (IOP), ocular perfusion pressure (OPP), retrobulbar blood flow, and retinal capillary blood flow were non-invasively measured (ultrasound and laser Doppler modalities, respectively) before and one month after antioxidant nutraceuticals and placebo administration. Changes in measurements between the active supplement and placebo arms were evaluated using paired t-tests, with p < 0.05 considered statistically significant. Results: Antioxidant supplementation produced a statistically significant increase in peak systolic and/or end diastolic blood flow velocities in all retrobulbar blood vessels compared to placebo. Vascular resistance was also reduced in central retinal and nasal short posterior ciliary arteries following antioxidant administration. Additionally, antioxidant supplementation increased superior and inferior temporal retinal capillary mean blood flow and the ratio of active to non-active retina capillaries compared to placebo. Conclusion: One-month oral administration of antioxidants produced increases in biomarkers of ocular blood flow within retinal and retrobulbar vascular beds in patients with OAG.

Original languageEnglish (US)
JournalActa Ophthalmologica
DOIs
StateAccepted/In press - 2017

Fingerprint

Glaucoma
Antioxidants
Placebos
Open Angle Glaucoma
Dietary Supplements
Ciliary Arteries
Ginkgo biloba
Doppler Ultrasonography
Retinal Vessels
Blood Flow Velocity
Intraocular Pressure
Nose
Vascular Resistance
Cross-Over Studies
Blood Vessels
Oral Administration
Retina
Lasers
Arm
Perfusion

Keywords

  • Antioxidants
  • Dietary supplement
  • Glaucoma
  • Ocular blood flow
  • Vitamins

ASJC Scopus subject areas

  • Ophthalmology

Cite this

The effects of antioxidants on ocular blood flow in patients with glaucoma. / Harris, Alon; Gross, Josh; Moore, Nicholas; Do, Thai; Huang, Amelia; Gama, Willy; Siesky, Brent.

In: Acta Ophthalmologica, 2017.

Research output: Contribution to journalArticle

Harris, Alon ; Gross, Josh ; Moore, Nicholas ; Do, Thai ; Huang, Amelia ; Gama, Willy ; Siesky, Brent. / The effects of antioxidants on ocular blood flow in patients with glaucoma. In: Acta Ophthalmologica. 2017.
@article{fb7b2f4a8596416bab77783aaf32c7db,
title = "The effects of antioxidants on ocular blood flow in patients with glaucoma",
abstract = "Purpose: To investigate the effects of an antioxidant dietary supplement that includes Ginkgo biloba, on retinal and retrobulbar blood flow in patients with open-angle glaucoma (OAG). Methods: Forty-five patients with confirmed OAG were enroled in a randomized, double blinded, placebo-controlled cross-over study. Baseline and postadministration measurements of intraocular pressure (IOP), ocular perfusion pressure (OPP), retrobulbar blood flow, and retinal capillary blood flow were non-invasively measured (ultrasound and laser Doppler modalities, respectively) before and one month after antioxidant nutraceuticals and placebo administration. Changes in measurements between the active supplement and placebo arms were evaluated using paired t-tests, with p < 0.05 considered statistically significant. Results: Antioxidant supplementation produced a statistically significant increase in peak systolic and/or end diastolic blood flow velocities in all retrobulbar blood vessels compared to placebo. Vascular resistance was also reduced in central retinal and nasal short posterior ciliary arteries following antioxidant administration. Additionally, antioxidant supplementation increased superior and inferior temporal retinal capillary mean blood flow and the ratio of active to non-active retina capillaries compared to placebo. Conclusion: One-month oral administration of antioxidants produced increases in biomarkers of ocular blood flow within retinal and retrobulbar vascular beds in patients with OAG.",
keywords = "Antioxidants, Dietary supplement, Glaucoma, Ocular blood flow, Vitamins",
author = "Alon Harris and Josh Gross and Nicholas Moore and Thai Do and Amelia Huang and Willy Gama and Brent Siesky",
year = "2017",
doi = "10.1111/aos.13530",
language = "English (US)",
journal = "Acta Ophthalmologica",
issn = "1755-375X",
publisher = "Wiley-Blackwell",

}

TY - JOUR

T1 - The effects of antioxidants on ocular blood flow in patients with glaucoma

AU - Harris, Alon

AU - Gross, Josh

AU - Moore, Nicholas

AU - Do, Thai

AU - Huang, Amelia

AU - Gama, Willy

AU - Siesky, Brent

PY - 2017

Y1 - 2017

N2 - Purpose: To investigate the effects of an antioxidant dietary supplement that includes Ginkgo biloba, on retinal and retrobulbar blood flow in patients with open-angle glaucoma (OAG). Methods: Forty-five patients with confirmed OAG were enroled in a randomized, double blinded, placebo-controlled cross-over study. Baseline and postadministration measurements of intraocular pressure (IOP), ocular perfusion pressure (OPP), retrobulbar blood flow, and retinal capillary blood flow were non-invasively measured (ultrasound and laser Doppler modalities, respectively) before and one month after antioxidant nutraceuticals and placebo administration. Changes in measurements between the active supplement and placebo arms were evaluated using paired t-tests, with p < 0.05 considered statistically significant. Results: Antioxidant supplementation produced a statistically significant increase in peak systolic and/or end diastolic blood flow velocities in all retrobulbar blood vessels compared to placebo. Vascular resistance was also reduced in central retinal and nasal short posterior ciliary arteries following antioxidant administration. Additionally, antioxidant supplementation increased superior and inferior temporal retinal capillary mean blood flow and the ratio of active to non-active retina capillaries compared to placebo. Conclusion: One-month oral administration of antioxidants produced increases in biomarkers of ocular blood flow within retinal and retrobulbar vascular beds in patients with OAG.

AB - Purpose: To investigate the effects of an antioxidant dietary supplement that includes Ginkgo biloba, on retinal and retrobulbar blood flow in patients with open-angle glaucoma (OAG). Methods: Forty-five patients with confirmed OAG were enroled in a randomized, double blinded, placebo-controlled cross-over study. Baseline and postadministration measurements of intraocular pressure (IOP), ocular perfusion pressure (OPP), retrobulbar blood flow, and retinal capillary blood flow were non-invasively measured (ultrasound and laser Doppler modalities, respectively) before and one month after antioxidant nutraceuticals and placebo administration. Changes in measurements between the active supplement and placebo arms were evaluated using paired t-tests, with p < 0.05 considered statistically significant. Results: Antioxidant supplementation produced a statistically significant increase in peak systolic and/or end diastolic blood flow velocities in all retrobulbar blood vessels compared to placebo. Vascular resistance was also reduced in central retinal and nasal short posterior ciliary arteries following antioxidant administration. Additionally, antioxidant supplementation increased superior and inferior temporal retinal capillary mean blood flow and the ratio of active to non-active retina capillaries compared to placebo. Conclusion: One-month oral administration of antioxidants produced increases in biomarkers of ocular blood flow within retinal and retrobulbar vascular beds in patients with OAG.

KW - Antioxidants

KW - Dietary supplement

KW - Glaucoma

KW - Ocular blood flow

KW - Vitamins

UR - http://www.scopus.com/inward/record.url?scp=85026730322&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85026730322&partnerID=8YFLogxK

U2 - 10.1111/aos.13530

DO - 10.1111/aos.13530

M3 - Article

C2 - 28772005

AN - SCOPUS:85026730322

JO - Acta Ophthalmologica

JF - Acta Ophthalmologica

SN - 1755-375X

ER -