The effects of droperidol in perforating keratoplasty

Hanna J. Garzozi, Raneen Shehadeh-Masha'our, Mostafa Somri, Larry Kagemann, Alon Harris

Research output: Contribution to journalArticle

1 Scopus citations


Purpose: To evaluate the intraoperative and postoperative effects of droperidol administered with general anesthesia during perforating keratoplasty. Methods: A prospective, randomized, double-masked clinical trial. Twenty-seven patients undergoing penetrating keratoplasty under general anesthesia were included. Patients were assigned randomly to two groups. Fifteen subjects received droperidol during induction of general anesthesia. Twelve control patients received general anesthesia without droperidol. Results: Droperidol significantly reduced fellow eye intraocular pressure (p < 0.0001). Intraoperative anterior chamber depth was significantly deeper with droperidol (p = 0.0002). Iris bulging was observed in 25% of the control group and 0% with droperidol. There was significantly less postoperative nausea in the droperidol group (p = 0.038). There was less postoperative vomiting in the droperidol group, although the difference was not significant (p = 0.07). Postoperative wound gaping was observed in 2 patients; both of them did not receive droperidol. Conclusions: Droperidol effectively reduces intraoperative and postoperative complications in keratoplasty surgery.

Original languageEnglish (US)
Pages (from-to)242-245
Number of pages4
Issue number4
StatePublished - Jun 1 2006


  • Droperidol
  • Intraocular pressure
  • Nausea
  • Penetrating keratoplasty

ASJC Scopus subject areas

  • Ophthalmology

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  • Cite this

    Garzozi, H. J., Shehadeh-Masha'our, R., Somri, M., Kagemann, L., & Harris, A. (2006). The effects of droperidol in perforating keratoplasty. Ophthalmologica, 220(4), 242-245.