The effects of glutathione depletion on the biodistribution of Cu(PTSM) in rats

Amy Barnhart-Bott, Mark Green

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The tissue retention of radiocopper afforded by intravenous injection of the proposed blood flow imaging agent, 62Cu-labeled copper(II) pyruvaldehyde bis(N4-methylthiosemicarbazone) [Cu(PTSM)], is thought to result from reductive decomposition of the copper(II) complex by intracellular sulfhydryls (e.g. glutathione, GSH). To determine if the tissue uptake and retention of this tracer adequately measures perfusion in tissues containing altered GSH concentrations, the biodistribution of copper-67 labeled Cu(PTSM) was determined in GSH-depleted rats. Despite treatment to induce relatively large reductions in tissue GSH levels, it was found that only very small changes in the biodistribution of copper-labeled Cu(PTSM) occurred in the treated rats compared to untreated controls.

Original languageEnglish (US)
Pages (from-to)865-869
Number of pages5
JournalInternational Journal of Radiation Applications and Instrumentation.
Volume18
Issue number8
DOIs
StatePublished - 1991
Externally publishedYes

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Glutathione
Copper
Pyruvaldehyde
Intravenous Injections
Perfusion
copper pyruvaldehyde bis(N(4)-methylthiosemicarbazone) complex
Therapeutics

Cite this

The effects of glutathione depletion on the biodistribution of Cu(PTSM) in rats. / Barnhart-Bott, Amy; Green, Mark.

In: International Journal of Radiation Applications and Instrumentation., Vol. 18, No. 8, 1991, p. 865-869.

Research output: Contribution to journalArticle

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