The effects of intrathecal hypotension on tissue perfusion and pathophysiological outcome after acute spinal cord injury

Eric Horn, Nicholas Theodore, Rachid Assina, Robert F. Spetzler, Volker K H Sonntag, Mark C. Preul

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Object: Venous stasis and intrathecal hypertension are believed to play a significant role in the hypoperfusion present in the spinal cord following injury. Lowering the intrathecal pressure via cerebrospinal fluid (CSF) drainage has been effective in treating spinal cord ischemia during aorta surgery. The purpose of the present study was to determine whether CSF drainage increases spinal cord perfusion and improves outcome after spinal injury in an animal model. Methods: Anesthetized adult rabbits were subjected to a severe contusion spinal cord injury (SCI). Cerebrospinal fluid was then drained via a catheter to lower the intrathecal pressure by 10 mm Hg. Tissue perfusion was assessed at the site of injury, and values obtained before and after CSF drainage were compared. Two other cohorts of animals were subjected to SCI: 1 group subsequently underwent CSF drainage and the other did not. Results of histological analysis, motor evoked potential and motor function testing were compared between the 2 cohorts at 4 weeks postinjury. Results: Cerebrospinal fluid drainage led to no significant improvement in spinal cord tissue perfusion. Four weeks after injury, the animals that underwent CSF drainage demonstrated significantly smaller areas of tissue damage at the injury site. There were no differences in motor evoked potentials or motor score outcomes at 4 weeks postinjury. Conclusions: Cerebrospinal fluid drainage effectively lowers intrathecal pressure and decreases the amount of tissue damage in an animal model of spinal cord injury. Further studies are needed to determine whether different draining regimens can improve motor or electrophysiological outcomes.

Original languageEnglish
Article numberE12
JournalNeurosurgical Focus
Volume25
Issue number5
DOIs
StatePublished - 2008

Fingerprint

Spinal Cord Injuries
Hypotension
Perfusion
Motor Evoked Potentials
Pressure
Spinal Cord
Wounds and Injuries
Animal Models
Spinal Cord Ischemia
Spinal Injuries
Contusions
Cerebrospinal Fluid Leak
Cerebrospinal Fluid
Aorta
Catheters
Rabbits
Hypertension

Keywords

  • CSF drainage
  • Rabbit
  • Spinal cord ischemia
  • Spinal trauma

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

Cite this

The effects of intrathecal hypotension on tissue perfusion and pathophysiological outcome after acute spinal cord injury. / Horn, Eric; Theodore, Nicholas; Assina, Rachid; Spetzler, Robert F.; Sonntag, Volker K H; Preul, Mark C.

In: Neurosurgical Focus, Vol. 25, No. 5, E12, 2008.

Research output: Contribution to journalArticle

Horn, Eric ; Theodore, Nicholas ; Assina, Rachid ; Spetzler, Robert F. ; Sonntag, Volker K H ; Preul, Mark C. / The effects of intrathecal hypotension on tissue perfusion and pathophysiological outcome after acute spinal cord injury. In: Neurosurgical Focus. 2008 ; Vol. 25, No. 5.
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