The effects of methylphenidate on prepulse inhibition during attended and ignored prestimuli among boys with attention-deficit hyperactivity disorder

Larry W. Hawk, Andrew R. Yartz, William E. Pelham, Thomas Lock

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

Rationale and objectives: The present study investigated attentional modification of prepulse inhibition of startle among boys with and without attention-deficit hyperactivity disorder (ADHD). Two hypotheses were tested: (1) whether ADHD is associated with diminished prepulse inhibition during attended prestimuli, but not ignored prestimuli, and (2) whether methylphenidate selectively increases prepulse inhibition to attended prestimuli among boys with ADHD. Methods: Participants were 17 boys with ADHD and 14 controls. Participants completed a tone discrimination task in each of two sessions separated by 1 week. ADHD boys were administered methylphenidate (0.3 mg/kg) in one session and placebo in the other session in a randomized, double-blind fashion. During each series of 72 tones (75 dB; half 1200-Hz, half 400-Hz), participants were paid to attend to one pitch and ignore the other. Bilateral eyeblink electromy-ogram startle responses were recorded in response to acoustic probes (50-ms, 102-dB white noise) presented following the onset of two-thirds of tones, and during one-third of intertrial intervals. Results: Relative to controls, boys with ADHD exhibited diminished prepulse inhibition 120 ms after onset of attended but not ignored prestimuli following placebo administration. Methylphenidate selectively increased prepulse inhibition to attended prestimuli at 120 ms among boys with ADHD to a level comparable to that of controls, who did not receive methylphenidate. Conclusions: These data are consistent with the hypothesis that ADHD involves diminished selective attention and suggest that methylphenidate ameliorates the symptoms of ADHD, at least in part, by altering an early attentional mechanism.

Original languageEnglish (US)
Pages (from-to)118-127
Number of pages10
JournalPsychopharmacology
Volume165
Issue number2
DOIs
StatePublished - 2003
Externally publishedYes

Fingerprint

Methylphenidate
Attention Deficit Disorder with Hyperactivity
Startle Reflex
Placebos
Prepulse Inhibition
Acoustics

Keywords

  • ADHD
  • Attention-deficit hyperactivity disorder
  • Methylphenidate
  • Prepulse inhibition
  • Startle reflex
  • Stimulants

ASJC Scopus subject areas

  • Pharmacology

Cite this

The effects of methylphenidate on prepulse inhibition during attended and ignored prestimuli among boys with attention-deficit hyperactivity disorder. / Hawk, Larry W.; Yartz, Andrew R.; Pelham, William E.; Lock, Thomas.

In: Psychopharmacology, Vol. 165, No. 2, 2003, p. 118-127.

Research output: Contribution to journalArticle

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