The effects of pharmacological doses of 2-deoxyglucose on cerebral blood flow in healthy volunteers

Igor Elman, Louis Sokoloff, Caleb M. Adler, Neil Weisenfeld, Alan Breier

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

The effects of glucose deprivation on cerebral blood flow (CBF) have been extensively investigated during insulin-induced hypoglycemia in laboratory animals. Pharmacological doses of glucose analog, 2-deoxyglucose (2DG), is an alternative glucoprivic agent that in contrast to insulin, directly inhibits glycolysis and glucose utilization. Both glucoprivic conditions markedly increase CBF in laboratory animals. How 2DG affects CBF in humans is still undetermined. In the present study we have employed H2 15O positron emission tomography (PET) to examine the effects of pharmacological doses of 2DG (40 mg/kg) on regional and global cerebral blood flow in 10 brain areas in 13 healthy volunteers. 2DG administration significantly raised regional CBF (rCBF) in the cingulate gyrus, sensorimotor cortex, superior temporal cortex, occipital cortex, basal ganglia, limbic system and hypothalamus. 2DG produced a trend towards elevated CBF in whole brain and frontal cortex, while no changes were observed in the corpus callosum and thalamus. In addition, 2DG significantly decreased body temperature and mean arterial pressure (MAP). Maximal percent changes in hypothalamic rCBF were significantly correlated with maximal changes in body temperature but not with MAP. These results indicate that cerebral glucoprivation produced by pharmacological doses of 2DG is accompanied by widespread activation of cortical and subcortical blood flow and that the blood flow changes in the hypothalamus may be related to 2DG-induced hypothermia.

Original languageEnglish (US)
Pages (from-to)243-249
Number of pages7
JournalBrain Research
Volume815
Issue number2
DOIs
StatePublished - Jan 9 1999
Externally publishedYes

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Cerebrovascular Circulation
Deoxyglucose
Healthy Volunteers
Pharmacology
Laboratory Animals
Glucose
Hypothalamus
Arterial Pressure
Body Temperature Changes
Insulin
Induced Hypothermia
Occipital Lobe
Limbic System
Corpus Callosum
Gyrus Cinguli
Regional Blood Flow
Brain
Frontal Lobe
Glycolysis
Temporal Lobe

Keywords

  • Body temperature
  • Glucose deprivation
  • Hypothalamus
  • Mean arterial pressure
  • PET

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

The effects of pharmacological doses of 2-deoxyglucose on cerebral blood flow in healthy volunteers. / Elman, Igor; Sokoloff, Louis; M. Adler, Caleb; Weisenfeld, Neil; Breier, Alan.

In: Brain Research, Vol. 815, No. 2, 09.01.1999, p. 243-249.

Research output: Contribution to journalArticle

Elman, Igor ; Sokoloff, Louis ; M. Adler, Caleb ; Weisenfeld, Neil ; Breier, Alan. / The effects of pharmacological doses of 2-deoxyglucose on cerebral blood flow in healthy volunteers. In: Brain Research. 1999 ; Vol. 815, No. 2. pp. 243-249.
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