The effects of PPAR-γ ligand pioglitazone on platelet aggregation and arterial thrombus formation

Dayuan Li, Kui Chen, Nandita Sinha, Xingjiang Zhang, Yin Wang, Anjan Sinha, Francesco Romeo, Jawahar L. Mehta

Research output: Contribution to journalArticle

86 Citations (Scopus)

Abstract

Background: It has been suggested that peroxisome proliferator-activated receptor (PPAR)-γ ligands reduce the development of atherosclerosis and myocardial ischemia-reperfusion injury; both of these phenomena are associated with platelet activation. We postulated that PPAR-γ activation would inhibit platelet activation and intra-arterial thrombus formation. Methods and results: Sprague-Dawley rats were fed chow mixed with pioglitazone (1 or 10 mg/kg/day) for 7 to 10 days. A filter soaked in 30% FeCl3 was applied around the abdominal aorta to study the patterns of arterial thrombogenesis. The aortic blood flow was continuously monitored using an ultrasonic Doppler flow probe. ADP and arachidonic acid-induced platelet aggregation and the expression of constitutive nitric oxide synthase (cNOS) and thrombomodulin in aorta were measured. Pioglitazone feeding delayed the time to occlusive thrombus formation by 40% (P

Original languageEnglish (US)
Pages (from-to)907-912
Number of pages6
JournalCardiovascular Research
Volume65
Issue number4
DOIs
StatePublished - Mar 1 2005
Externally publishedYes

Fingerprint

pioglitazone
Peroxisome Proliferator-Activated Receptors
Platelet Activation
Platelet Aggregation
Thrombosis
Ligands
Myocardial Reperfusion Injury
Thrombomodulin
Abdominal Aorta
Reperfusion Injury
Arachidonic Acid
Ultrasonics
Nitric Oxide Synthase
Adenosine Diphosphate
Myocardial Ischemia
Sprague Dawley Rats
Aorta
Atherosclerosis

Keywords

  • Arterial thrombosis
  • cNOS
  • PPAR-γ agonist
  • Thrombomodulin

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

The effects of PPAR-γ ligand pioglitazone on platelet aggregation and arterial thrombus formation. / Li, Dayuan; Chen, Kui; Sinha, Nandita; Zhang, Xingjiang; Wang, Yin; Sinha, Anjan; Romeo, Francesco; Mehta, Jawahar L.

In: Cardiovascular Research, Vol. 65, No. 4, 01.03.2005, p. 907-912.

Research output: Contribution to journalArticle

Li, Dayuan ; Chen, Kui ; Sinha, Nandita ; Zhang, Xingjiang ; Wang, Yin ; Sinha, Anjan ; Romeo, Francesco ; Mehta, Jawahar L. / The effects of PPAR-γ ligand pioglitazone on platelet aggregation and arterial thrombus formation. In: Cardiovascular Research. 2005 ; Vol. 65, No. 4. pp. 907-912.
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AU - Sinha, Anjan

AU - Romeo, Francesco

AU - Mehta, Jawahar L.

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