The effects of prior exposure to bleomycin on the incidence of pulmonary toxicities in a group of patients with disseminated testicular carcinomas

Stanley T. Crooke, Lawrence H. Einhorn, Robert L. Comis, Joan C. D'Aoust, Archie W. Prestayko

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

The incidence of pulmonary toxicities in 12 patients with prior exposure to bleomycin (BLM) was compared to the incidence of pulmonary toxicities in a matched group of 73 patients with stage III or IV testicular carcinomas treated with a regimen containing vinblastine, bleomycin, and cis‐diamminedichloroplatinum. The comparison demonstrates that prior exposure to bleomycin constitutes a significant risk factor and that the risk is additive; ie, prior doses should be added to current doses to determine the cumulative dose‐related probability of development of pulmonary toxicities.

Original languageEnglish (US)
Pages (from-to)93-98
Number of pages6
JournalMedical and Pediatric Oncology
Volume5
Issue number1
DOIs
StatePublished - 1978

Keywords

  • bleomycin
  • pulmonary toxicity
  • testicular carcinoma

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'The effects of prior exposure to bleomycin on the incidence of pulmonary toxicities in a group of patients with disseminated testicular carcinomas'. Together they form a unique fingerprint.

  • Cite this