The effects of raloxifene hydrochloride on ocular hemodynamics and visual function

Brent Siesky, Akon Harris, Nisha Kheradiya, Rita Ehrlich, Carissa Klaas, Boaris Kaplan, Yara Catoira, Lynne McCranor, Carlos Rospigliosi, Mira Harris

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1 Scopus citations

Abstract

Objective: To assess the comprehensive effects of raloxifene hydrochloride on retinal, choroidal and retrobulbar hemodynamics and on visual function in post-menopausal women. Design: Twenty-four post-menopausal women (age 55 ± 3.8 years) were recruited for this cross-sectional study: 12 received placebo and 12 received raloxifene hydrochloride 60 mg once a day for 3 months. Baseline measurements of both groups included heart rate (HR), blood pressure (BP), visual acuity, contrast sensitivity and intraocular pressure (IOP) for both eyes. A comprehensive ocular blood flow (OBF) assessment was obtained for each patient in a randomly chosen study eye. Retinal blood flow data was obtained using confocal scanning laser Doppler flowmetry [Heidelberg Retinal Flowmeter (HRF)]. Color Doppler imaging (CDI) was used to assess retrobulbar hemodynamics in the ophthalmic, central retinal, short nasal and temporal posterior ciliary arteries. Baseline vision and hemodynamics in post-menopausal subjects were compared using paired Student's t tests, and the percentage change in baseline versus 3-month parameters was analyzed. Results: There were no statistically significant differences between 3 months of raloxifene therapy and placebo in terms of age, HR, arterial or mean BP, visual acuity, contrast sensitivity, IOP or retinal or retrobulbar blood flow. Conclusion: Raloxifene therapy at 60 mg/day had no clinically significant impact on BP, IOP or OBF in post-menopausal women.

Original languageEnglish (US)
Pages (from-to)225-230
Number of pages6
JournalInternational Ophthalmology
Volume29
Issue number4
DOIs
StatePublished - Jan 1 2009

Keywords

  • Blood flow
  • Hormone
  • Raloxifene
  • Vision

ASJC Scopus subject areas

  • Ophthalmology

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    Siesky, B., Harris, A., Kheradiya, N., Ehrlich, R., Klaas, C., Kaplan, B., Catoira, Y., McCranor, L., Rospigliosi, C., & Harris, M. (2009). The effects of raloxifene hydrochloride on ocular hemodynamics and visual function. International Ophthalmology, 29(4), 225-230. https://doi.org/10.1007/s10792-008-9224-4