The effects of sodium chromate on the proximal tubules of the rat kidney. Fine structural damage and lysozymuria

A. P. Evan, W. G. Dail

Research output: Contribution to journalArticle

73 Scopus citations


Sodium chromate (10 or 20 mgs/kgs intraperitoneally) induces structural changes which appear to be correlated with the amount of lysozyme in the urine. Chromate selectively affects the cells of the convuluted portion of the proximal tubule. The sequence of progressive changes leading to nephron damage are: swelling and loss of microvilli; formation of intracellular vacuoles of varied sizes; mitochondrial swelling and cytoplasmic liquefaction followed by desquamation. Tubular damage is greater at higher dose levels and at longer time intervals. The amount of lysozyme in the urine increases as damage to the proximal tubule cells becomes more pronounced, suggesting that urinary lysozyme activity may be a good indicator of severe proximal tubular damage.

Original languageEnglish (US)
Pages (from-to)704-715
Number of pages12
JournalLaboratory Investigation
Issue number6
StatePublished - Dec 1 1974


ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Biology
  • Cell Biology

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