Sodium chromate (10 or 20 mgs/kgs intraperitoneally) induces structural changes which appear to be correlated with the amount of lysozyme in the urine. Chromate selectively affects the cells of the convuluted portion of the proximal tubule. The sequence of progressive changes leading to nephron damage are: swelling and loss of microvilli; formation of intracellular vacuoles of varied sizes; mitochondrial swelling and cytoplasmic liquefaction followed by desquamation. Tubular damage is greater at higher dose levels and at longer time intervals. The amount of lysozyme in the urine increases as damage to the proximal tubule cells becomes more pronounced, suggesting that urinary lysozyme activity may be a good indicator of severe proximal tubular damage.
|Original language||English (US)|
|Number of pages||12|
|State||Published - Dec 1 1974|
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Molecular Biology
- Cell Biology