The efficacy of pentoxifylline in the treatment of vascular dementia: A systematic review

Michael C. Sha, Christopher M. Callahan

Research output: Contribution to journalReview article

29 Citations (Scopus)

Abstract

This systematic review seeks to (1) summarize the pharmacologic effects of pentoxifylline on the cerebrovasculature and (2) review critically the studies evaluating pentoxifylline in the treatment of vascular dementia. To retrieve all relevant published and unpublished studies, we performed with no language restrictions computer keyword searches of MEDLINE, EMBASE, and Cochrane Library databases; reviewed bibliographies; and contacted the pharmaceutical manufacturer. We included pertinent articles if they met three quality criteria: randomized, double-blinded, and placebo-controlled study design; objective diagnostic criteria for vascular dementia; and reported original data. The literature search identified a total of 20 articles; however, only four studies met the quality criteria for inclusion in this systematic review. All four studies suggested a trend toward improved cognitive function in patients treated with pentoxifylline. Three of the studies performed a subgroup analysis using a stricter definition for vascular dementia. In these secondary analyses, the studies noted statistically significant differences in cognitive function between placebo and treatment groups. In conclusion, this systematic review suggested a potential therapeutic role for pentoxifylline in vascular dementia. However, few studies met the quality criteria for inclusion in this systematic review, and most of these studies were small and had methodologic limitations.

Original languageEnglish (US)
Pages (from-to)46-54
Number of pages9
JournalAlzheimer disease and associated disorders
Volume17
Issue number1
DOIs
StatePublished - Jan 1 2003

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Pentoxifylline
Vascular Dementia
Cognition
Placebos
Bibliography
Therapeutics
MEDLINE
Libraries
Language
Databases
Pharmaceutical Preparations

Keywords

  • Pentoxifylline
  • Review
  • Treatment
  • Vascular dementia

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Psychiatry and Mental health
  • Neuroscience(all)

Cite this

The efficacy of pentoxifylline in the treatment of vascular dementia : A systematic review. / Sha, Michael C.; Callahan, Christopher M.

In: Alzheimer disease and associated disorders, Vol. 17, No. 1, 01.01.2003, p. 46-54.

Research output: Contribution to journalReview article

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