The efficacy of topical silicone gel elastomers in the treatment of hypertrophic scars, keloid scars, and post-laser exfoliation erythema

W. Gregory Chernoff, Harvey Cramer, Stephanie Su-Huang

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

Background: Dermatix is a Food and Drug Administration (FDA)-registered substantial equivalent to silicone gel sheeting for the prevention and management of hypertrophic scars and keloids. Methods: A 90-day prospective study evaluated the efficacy of Dermatix, silicone gel sheeting, and a combination of these treatments in improving scars for 30 patients. Each patient had a bilateral scar that served as an untreated control. The outcome measures included profilometry analysis of scar topography before and after punch biopsies of the control and treated scars, symptoms associated with the scars, and patient evaluations of the ease of treatment. Results: The results showed better resolution and improvement of scars with Dermatix treatment or the combined use of Dermatix and silicone gel sheeting than with silicone gel sheeting alone. Wound erythema was reduced, and collagen architectural reorientation was demonstrated histologically. Patients rated Dermatix as easier to use than silicone gel sheeting. Both Dermatix and silicone gel sheeting reduced symptoms of itching, irritation, and skin maceration. Conclusion: The results of this study indicate that Dermatix is a useful treatment for the management of abnormal scarring.

Original languageEnglish (US)
Pages (from-to)495-500
Number of pages6
JournalAesthetic Plastic Surgery
Volume31
Issue number5
DOIs
StatePublished - Oct 2007
Externally publishedYes

Fingerprint

Silicone Gels
Hypertrophic Cicatrix
Keloid
Silicone Elastomers
Erythema
Cicatrix
Lasers
Therapeutics
United States Food and Drug Administration
Pruritus
Collagen
Outcome Assessment (Health Care)
Prospective Studies
Biopsy
Skin
Wounds and Injuries

Keywords

  • Hypertrophic scar
  • Keloid
  • Silicone gel
  • Silicone gel sheeting

ASJC Scopus subject areas

  • Surgery

Cite this

The efficacy of topical silicone gel elastomers in the treatment of hypertrophic scars, keloid scars, and post-laser exfoliation erythema. / Chernoff, W. Gregory; Cramer, Harvey; Su-Huang, Stephanie.

In: Aesthetic Plastic Surgery, Vol. 31, No. 5, 10.2007, p. 495-500.

Research output: Contribution to journalArticle

@article{694b641eaa534df29ae587a2ef917b8d,
title = "The efficacy of topical silicone gel elastomers in the treatment of hypertrophic scars, keloid scars, and post-laser exfoliation erythema",
abstract = "Background: Dermatix is a Food and Drug Administration (FDA)-registered substantial equivalent to silicone gel sheeting for the prevention and management of hypertrophic scars and keloids. Methods: A 90-day prospective study evaluated the efficacy of Dermatix, silicone gel sheeting, and a combination of these treatments in improving scars for 30 patients. Each patient had a bilateral scar that served as an untreated control. The outcome measures included profilometry analysis of scar topography before and after punch biopsies of the control and treated scars, symptoms associated with the scars, and patient evaluations of the ease of treatment. Results: The results showed better resolution and improvement of scars with Dermatix treatment or the combined use of Dermatix and silicone gel sheeting than with silicone gel sheeting alone. Wound erythema was reduced, and collagen architectural reorientation was demonstrated histologically. Patients rated Dermatix as easier to use than silicone gel sheeting. Both Dermatix and silicone gel sheeting reduced symptoms of itching, irritation, and skin maceration. Conclusion: The results of this study indicate that Dermatix is a useful treatment for the management of abnormal scarring.",
keywords = "Hypertrophic scar, Keloid, Silicone gel, Silicone gel sheeting",
author = "Chernoff, {W. Gregory} and Harvey Cramer and Stephanie Su-Huang",
year = "2007",
month = "10",
doi = "10.1007/s00266-006-0218-1",
language = "English (US)",
volume = "31",
pages = "495--500",
journal = "Aesthetic Plastic Surgery",
issn = "0364-216X",
publisher = "Springer New York",
number = "5",

}

TY - JOUR

T1 - The efficacy of topical silicone gel elastomers in the treatment of hypertrophic scars, keloid scars, and post-laser exfoliation erythema

AU - Chernoff, W. Gregory

AU - Cramer, Harvey

AU - Su-Huang, Stephanie

PY - 2007/10

Y1 - 2007/10

N2 - Background: Dermatix is a Food and Drug Administration (FDA)-registered substantial equivalent to silicone gel sheeting for the prevention and management of hypertrophic scars and keloids. Methods: A 90-day prospective study evaluated the efficacy of Dermatix, silicone gel sheeting, and a combination of these treatments in improving scars for 30 patients. Each patient had a bilateral scar that served as an untreated control. The outcome measures included profilometry analysis of scar topography before and after punch biopsies of the control and treated scars, symptoms associated with the scars, and patient evaluations of the ease of treatment. Results: The results showed better resolution and improvement of scars with Dermatix treatment or the combined use of Dermatix and silicone gel sheeting than with silicone gel sheeting alone. Wound erythema was reduced, and collagen architectural reorientation was demonstrated histologically. Patients rated Dermatix as easier to use than silicone gel sheeting. Both Dermatix and silicone gel sheeting reduced symptoms of itching, irritation, and skin maceration. Conclusion: The results of this study indicate that Dermatix is a useful treatment for the management of abnormal scarring.

AB - Background: Dermatix is a Food and Drug Administration (FDA)-registered substantial equivalent to silicone gel sheeting for the prevention and management of hypertrophic scars and keloids. Methods: A 90-day prospective study evaluated the efficacy of Dermatix, silicone gel sheeting, and a combination of these treatments in improving scars for 30 patients. Each patient had a bilateral scar that served as an untreated control. The outcome measures included profilometry analysis of scar topography before and after punch biopsies of the control and treated scars, symptoms associated with the scars, and patient evaluations of the ease of treatment. Results: The results showed better resolution and improvement of scars with Dermatix treatment or the combined use of Dermatix and silicone gel sheeting than with silicone gel sheeting alone. Wound erythema was reduced, and collagen architectural reorientation was demonstrated histologically. Patients rated Dermatix as easier to use than silicone gel sheeting. Both Dermatix and silicone gel sheeting reduced symptoms of itching, irritation, and skin maceration. Conclusion: The results of this study indicate that Dermatix is a useful treatment for the management of abnormal scarring.

KW - Hypertrophic scar

KW - Keloid

KW - Silicone gel

KW - Silicone gel sheeting

UR - http://www.scopus.com/inward/record.url?scp=34548751852&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34548751852&partnerID=8YFLogxK

U2 - 10.1007/s00266-006-0218-1

DO - 10.1007/s00266-006-0218-1

M3 - Article

C2 - 17700980

AN - SCOPUS:34548751852

VL - 31

SP - 495

EP - 500

JO - Aesthetic Plastic Surgery

JF - Aesthetic Plastic Surgery

SN - 0364-216X

IS - 5

ER -