The EGLN-HIF O2-Sensing System: Multiple Inputs and Feedbacks

Mircea Ivan, William G. Kaelin

Research output: Contribution to journalReview article

53 Scopus citations

Abstract

The EGLN (also called PHD) prolyl hydroxylase enzymes and their canonical targets, the HIFα subunits, represent the core of an ancient oxygen-monitoring machinery used by metazoans. In this review, we highlight recent progress in understanding the overlapping versus specific roles of EGLN enzymes and HIF isoforms and discuss how feedback loops based on recently identified noncoding RNAs introduce additional layers of complexity to the hypoxic response. Based on novel interactions identified upstream and downstream of EGLNs, an integrated network connecting oxygen-sensing functions to metabolic and signaling pathways is gradually emerging with broad therapeutic implications.

Original languageEnglish (US)
Pages (from-to)772-779
Number of pages8
JournalMolecular Cell
Volume66
Issue number6
DOIs
StatePublished - Jun 15 2017

Keywords

  • EGLN
  • HIF1
  • HIF2
  • hypoxia
  • lncRNA
  • metabolism
  • miRNA
  • noncoding RNA
  • oxygen
  • PHD

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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