The emerging genomics and systems biology research lead to systems genomics studies

Mary Q u Yang, Kenji Yoshigoe, William Yang, Weida Tong, Xiang Qin, A. Dunker, Zhongxue Chen, Hamid R. Arbania, Jun S. Liu, Andrzej Niemierko, Jack Y. Yang

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Synergistically integrating multi-layer genomic data at systems level not only can lead to deeper insights into the molecular mechanisms related to disease initiation and progression, but also can guide pathway-based biomarker and drug target identification. With the advent of high-throughput next-generation sequencing technologies, sequencing both DNA and RNA has generated multi-layer genomic data that can provide DNA polymorphism, non-coding RNA, messenger RNA, gene expression, isoform and alternative splicing information. Systems biology on the other hand studies complex biological systems, particularly systematic study of complex molecular interactions within specific cells or organisms. Genomics and molecular systems biology can be merged into the study of genomic profiles and implicated biological functions at cellular or organism level. The prospectively emerging field can be referred to as systems genomics or genomic systems biology. The Mid-South Bioinformatics Centre (MBC) and Joint Bioinformatics Ph.D. Program of University of Arkansas at Little Rock and University of Arkansas for Medical Sciences are particularly interested in promoting education and research advancement in this prospectively emerging field. Based on past investigations and research outcomes, MBC is further utilizing differential gene and isoform/exon expression from RNA-seq and co-regulation from the ChiP-seq specific for different phenotypes in combination with protein-protein interactions, and protein-DNA interactions to construct high-level gene networks for an integrative genome-phoneme investigation at systems biology level.

Original languageEnglish (US)
Pages (from-to)I1
JournalBMC Genomics
Volume15
DOIs
StatePublished - 2014

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Systems Biology
Genomics
Computational Biology
Research
Protein Isoforms
RNA Sequence Analysis
Untranslated RNA
Proteins
Gene Regulatory Networks
DNA
Alternative Splicing
DNA Sequence Analysis
Information Systems
Disease Progression
Molecular Biology
Exons
Joints
Biomarkers
Outcome Assessment (Health Care)
Genome

ASJC Scopus subject areas

  • Medicine(all)

Cite this

The emerging genomics and systems biology research lead to systems genomics studies. / Yang, Mary Q u; Yoshigoe, Kenji; Yang, William; Tong, Weida; Qin, Xiang; Dunker, A.; Chen, Zhongxue; Arbania, Hamid R.; Liu, Jun S.; Niemierko, Andrzej; Yang, Jack Y.

In: BMC Genomics, Vol. 15, 2014, p. I1.

Research output: Contribution to journalArticle

Yang, MQU, Yoshigoe, K, Yang, W, Tong, W, Qin, X, Dunker, A, Chen, Z, Arbania, HR, Liu, JS, Niemierko, A & Yang, JY 2014, 'The emerging genomics and systems biology research lead to systems genomics studies', BMC Genomics, vol. 15, pp. I1. https://doi.org/10.1186/1471-2164-15-S11-I1
Yang, Mary Q u ; Yoshigoe, Kenji ; Yang, William ; Tong, Weida ; Qin, Xiang ; Dunker, A. ; Chen, Zhongxue ; Arbania, Hamid R. ; Liu, Jun S. ; Niemierko, Andrzej ; Yang, Jack Y. / The emerging genomics and systems biology research lead to systems genomics studies. In: BMC Genomics. 2014 ; Vol. 15. pp. I1.
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