The emerging role of electronic medical records in pharmacogenomics

R. A. Wilke, H. Xu, J. C. Denny, D. M. Roden, R. M. Krauss, C. A. McCarty, R. L. Davis, T. Skaar, J. Lamba, G. Savova

Research output: Contribution to journalReview article

116 Citations (Scopus)

Abstract

Health-care information technology and genotyping technology are both advancing rapidly, creating new opportunities for medical and scientific discovery. The convergence of these two technologies is now facilitating genetic association studies of unprecedented size within the context of routine clinical care. As a result, the medical community will soon be presented with a number of novel opportunities to bring functional genomics to the bedside in the area of pharmacotherapy. By linking biological material to comprehensive medical records, large multi-institutional biobanks are now poised to advance the field of pharmacogenomics through three distinct mechanisms: (i) retrospective assessment of previously known findings in a clinical practice-based setting, (ii) discovery of new associations in huge observational cohorts, and (iii) prospective application in a setting capable of providing real-time decision support. This review explores each of these translational mechanisms within a historical framework.

Original languageEnglish (US)
Pages (from-to)379-386
Number of pages8
JournalClinical Pharmacology and Therapeutics
Volume89
Issue number3
DOIs
StatePublished - Mar 1 2011

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Electronic Health Records
Pharmacogenetics
Technology
Medical Informatics
Biomedical Technology
Genetic Association Studies
Genomics
Medical Records
Drug Therapy

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

Cite this

Wilke, R. A., Xu, H., Denny, J. C., Roden, D. M., Krauss, R. M., McCarty, C. A., ... Savova, G. (2011). The emerging role of electronic medical records in pharmacogenomics. Clinical Pharmacology and Therapeutics, 89(3), 379-386. https://doi.org/10.1038/clpt.2010.260

The emerging role of electronic medical records in pharmacogenomics. / Wilke, R. A.; Xu, H.; Denny, J. C.; Roden, D. M.; Krauss, R. M.; McCarty, C. A.; Davis, R. L.; Skaar, T.; Lamba, J.; Savova, G.

In: Clinical Pharmacology and Therapeutics, Vol. 89, No. 3, 01.03.2011, p. 379-386.

Research output: Contribution to journalReview article

Wilke, RA, Xu, H, Denny, JC, Roden, DM, Krauss, RM, McCarty, CA, Davis, RL, Skaar, T, Lamba, J & Savova, G 2011, 'The emerging role of electronic medical records in pharmacogenomics', Clinical Pharmacology and Therapeutics, vol. 89, no. 3, pp. 379-386. https://doi.org/10.1038/clpt.2010.260
Wilke RA, Xu H, Denny JC, Roden DM, Krauss RM, McCarty CA et al. The emerging role of electronic medical records in pharmacogenomics. Clinical Pharmacology and Therapeutics. 2011 Mar 1;89(3):379-386. https://doi.org/10.1038/clpt.2010.260
Wilke, R. A. ; Xu, H. ; Denny, J. C. ; Roden, D. M. ; Krauss, R. M. ; McCarty, C. A. ; Davis, R. L. ; Skaar, T. ; Lamba, J. ; Savova, G. / The emerging role of electronic medical records in pharmacogenomics. In: Clinical Pharmacology and Therapeutics. 2011 ; Vol. 89, No. 3. pp. 379-386.
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