The ENCOURAGE healthy families study: A comparative effectiveness trial to reduce risk for type 2 diabetes in mothers and children

Tamara Hannon, Chandan Saha, Aaron Carroll, Kelly N.B. Palmer, Erin O'Kelly Phillips, David Marrero

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Introduction: Trials in adults have demonstrated that interventions targeting lifestyle are effective in preventing or delaying type 2 diabetes (T2D). To address this need in youth, we developed ENCOURAGE Healthy Families (ENCOURAGE), based on the US Diabetes Prevention Program (DPP). Study Design: Here, we present results of the ENCOURAGE randomized, comparative effectiveness trial in which we evaluated ENCOURAGE delivered to (1) mothers only, and (2) mothers with added content delivered to their children. Participants: The study was performed in Indianapolis, IN, at an academic medical center and the YMCA; December 2012 to April 2016. Women with a history of gestational diabetes mellitus (GDM) or prediabetes with children aged 8 to 15 years enrolled (n = 128). Outcome Measures: Outcomes were collected at baseline, postintervention (3 months), 6 and 12 months. The primary outcome was weight change at 3 months in adults; secondary outcomes included glycosylated hemoglobin (HbA1c), lipids, and blood pressure. Results: In neither program did mothers' weight change. HbA1c decreased at 3 months in both groups (mothers only=−0.09%, P =.019; mothers and children=−0.11%, P =.003). Participating children had a reduction in body mass index (BMI) percentile at 3 (−1.77, P =.014), 6 (−3.0, P =.002), and 12 months (−2.91, P =.004). HbA1c decreased in children in both groups (mothers only = −0.12% at 3 months [P <.0001], −0.13% at 6 months [P <.001], and −0.07% at 12 months [P =.001]; mothers and children = −0.08% at 3 months (P <.0001), −0.07% at 6 months (P =.0004), and −0.04% at 12 months (P =.03). Conclusion: ENCOURAGE was beneficial for reducing BMI percentile in participating children.

Original languageEnglish (US)
Pages (from-to)1041-1049
Number of pages9
JournalPediatric Diabetes
Volume19
Issue number6
DOIs
StatePublished - Sep 1 2018

Fingerprint

Type 2 Diabetes Mellitus
Mothers
Body Mass Index
Prediabetic State
Weights and Measures
Gestational Diabetes
Glycosylated Hemoglobin A
Life Style
Outcome Assessment (Health Care)
Blood Pressure
Lipids

Keywords

  • obesity
  • pediatric
  • prediabetes
  • prevention
  • weight

ASJC Scopus subject areas

  • Internal Medicine
  • Pediatrics, Perinatology, and Child Health
  • Endocrinology, Diabetes and Metabolism

Cite this

The ENCOURAGE healthy families study : A comparative effectiveness trial to reduce risk for type 2 diabetes in mothers and children. / Hannon, Tamara; Saha, Chandan; Carroll, Aaron; Palmer, Kelly N.B.; O'Kelly Phillips, Erin; Marrero, David.

In: Pediatric Diabetes, Vol. 19, No. 6, 01.09.2018, p. 1041-1049.

Research output: Contribution to journalArticle

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abstract = "Introduction: Trials in adults have demonstrated that interventions targeting lifestyle are effective in preventing or delaying type 2 diabetes (T2D). To address this need in youth, we developed ENCOURAGE Healthy Families (ENCOURAGE), based on the US Diabetes Prevention Program (DPP). Study Design: Here, we present results of the ENCOURAGE randomized, comparative effectiveness trial in which we evaluated ENCOURAGE delivered to (1) mothers only, and (2) mothers with added content delivered to their children. Participants: The study was performed in Indianapolis, IN, at an academic medical center and the YMCA; December 2012 to April 2016. Women with a history of gestational diabetes mellitus (GDM) or prediabetes with children aged 8 to 15 years enrolled (n = 128). Outcome Measures: Outcomes were collected at baseline, postintervention (3 months), 6 and 12 months. The primary outcome was weight change at 3 months in adults; secondary outcomes included glycosylated hemoglobin (HbA1c), lipids, and blood pressure. Results: In neither program did mothers' weight change. HbA1c decreased at 3 months in both groups (mothers only=−0.09{\%}, P =.019; mothers and children=−0.11{\%}, P =.003). Participating children had a reduction in body mass index (BMI) percentile at 3 (−1.77, P =.014), 6 (−3.0, P =.002), and 12 months (−2.91, P =.004). HbA1c decreased in children in both groups (mothers only = −0.12{\%} at 3 months [P <.0001], −0.13{\%} at 6 months [P <.001], and −0.07{\%} at 12 months [P =.001]; mothers and children = −0.08{\%} at 3 months (P <.0001), −0.07{\%} at 6 months (P =.0004), and −0.04{\%} at 12 months (P =.03). Conclusion: ENCOURAGE was beneficial for reducing BMI percentile in participating children.",
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