The endothelial cell in ischemic acute kidney injury

Implications for acute and chronic function

Research output: Contribution to journalArticle

269 Citations (Scopus)

Abstract

Recent evidence suggests that injury to the renal vasculature may play an important role in the pathogenesis of both early and chronic ischemic acute kidney injury (AKI). Established and new data support the suggestion that vascular injury, in particular, endothelial cell injury, participates in the extent and maintenance of AKI by pathways that are related to vascular tone. Early alterations in peritubular capillary blood flow during reperfusion has been documented and associated with loss of normal endothelial cell function, which can be replaced pharmacologically or with cell replacement interventions. Distorted peritubular capillary morphology is associated with loss of barrier function that may contribute to early alterations in vascular stasis. In addition, ischemia induces alterations in endothelial cells that may promote inflammation and procoagulant activity, thus contributing to vascular congestion. Reductions in microvasculature density may play a critical part in the progression of chronic kidney disease following initial recovery from ischemia/reperfusion-induced AKI. The exact nature of how capillary loss alters renal function and predisposes renal disease is thought to be due at least in part to hypoxia. Finally, the loss of endothelial cell function may represent an important therapeutic target in which nitric oxide, vascular trophic support, and/or endothelial progenitor cells may show potential importance in ameliorating the acute and/or chronic effects of ischemic AKI.

Original languageEnglish
Pages (from-to)151-156
Number of pages6
JournalKidney International
Volume72
Issue number2
DOIs
StatePublished - Jul 2007

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Acute Kidney Injury
Blood Vessels
Endothelial Cells
Kidney
Reperfusion
Ischemia
Vascular System Injuries
Wounds and Injuries
Microvessels
Chronic Renal Insufficiency
Nitric Oxide
Maintenance
Inflammation
Therapeutics

Keywords

  • Acute renal failure
  • Angiogenesis
  • Hypotoxia
  • Inflammation
  • Vascular function
  • VEGF

ASJC Scopus subject areas

  • Nephrology

Cite this

The endothelial cell in ischemic acute kidney injury : Implications for acute and chronic function. / Basile, David.

In: Kidney International, Vol. 72, No. 2, 07.2007, p. 151-156.

Research output: Contribution to journalArticle

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