The endothelial monocyte-activating polypeptide II (EMAP II) is a substrate for caspase-7

Heike A. Behrensdorf, Marc Van De Craen, Ulrike E. Knies, Peter Vandenabeele, Matthias Clauss

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

Endothelial monocyte-activating polypeptide II (EMAP II) is a proinflammatory cytokine and a chemoattractant for leukocytes. The mature cytokine is formed in apoptotic cells by cleavage of the precursor proEMAP II. Here we show that caspase-7 is capable of cleaving proEMAP II in vitro. A proEMAP II mutant, in which the ASTD cleavage site was changed to the sequence ASTA, was not processed by caspase-7. The caspase-7-mediated generation and release of mature EMAP II may provide a mechanism for leukocyte recruitment to sites of programmed cell death, and thus may link apoptosis to inflammation. Copyright (C) 2000 Federation of European Biochemical Societies.

Original languageEnglish (US)
Pages (from-to)143-147
Number of pages5
JournalFEBS Letters
Volume466
Issue number1
DOIs
StatePublished - Jan 21 2000
Externally publishedYes

Fingerprint

Caspase 7
Leukocytes
Substrates
Cytokines
Chemotactic Factors
Cell death
Cell Death
Cells
Apoptosis
Inflammation
small inducible cytokine subfamily E, member 1

Keywords

  • Apoptosis
  • Caspase-7
  • Endothelial monocyte-activating polypeptide II
  • Leukocyte recruitment

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

The endothelial monocyte-activating polypeptide II (EMAP II) is a substrate for caspase-7. / Behrensdorf, Heike A.; Van De Craen, Marc; Knies, Ulrike E.; Vandenabeele, Peter; Clauss, Matthias.

In: FEBS Letters, Vol. 466, No. 1, 21.01.2000, p. 143-147.

Research output: Contribution to journalArticle

Behrensdorf, Heike A. ; Van De Craen, Marc ; Knies, Ulrike E. ; Vandenabeele, Peter ; Clauss, Matthias. / The endothelial monocyte-activating polypeptide II (EMAP II) is a substrate for caspase-7. In: FEBS Letters. 2000 ; Vol. 466, No. 1. pp. 143-147.
@article{c526c83676b14ac5ac627b175b26f29b,
title = "The endothelial monocyte-activating polypeptide II (EMAP II) is a substrate for caspase-7",
abstract = "Endothelial monocyte-activating polypeptide II (EMAP II) is a proinflammatory cytokine and a chemoattractant for leukocytes. The mature cytokine is formed in apoptotic cells by cleavage of the precursor proEMAP II. Here we show that caspase-7 is capable of cleaving proEMAP II in vitro. A proEMAP II mutant, in which the ASTD cleavage site was changed to the sequence ASTA, was not processed by caspase-7. The caspase-7-mediated generation and release of mature EMAP II may provide a mechanism for leukocyte recruitment to sites of programmed cell death, and thus may link apoptosis to inflammation. Copyright (C) 2000 Federation of European Biochemical Societies.",
keywords = "Apoptosis, Caspase-7, Endothelial monocyte-activating polypeptide II, Leukocyte recruitment",
author = "Behrensdorf, {Heike A.} and {Van De Craen}, Marc and Knies, {Ulrike E.} and Peter Vandenabeele and Matthias Clauss",
year = "2000",
month = "1",
day = "21",
doi = "10.1016/S0014-5793(99)01777-9",
language = "English (US)",
volume = "466",
pages = "143--147",
journal = "FEBS Letters",
issn = "0014-5793",
publisher = "Elsevier",
number = "1",

}

TY - JOUR

T1 - The endothelial monocyte-activating polypeptide II (EMAP II) is a substrate for caspase-7

AU - Behrensdorf, Heike A.

AU - Van De Craen, Marc

AU - Knies, Ulrike E.

AU - Vandenabeele, Peter

AU - Clauss, Matthias

PY - 2000/1/21

Y1 - 2000/1/21

N2 - Endothelial monocyte-activating polypeptide II (EMAP II) is a proinflammatory cytokine and a chemoattractant for leukocytes. The mature cytokine is formed in apoptotic cells by cleavage of the precursor proEMAP II. Here we show that caspase-7 is capable of cleaving proEMAP II in vitro. A proEMAP II mutant, in which the ASTD cleavage site was changed to the sequence ASTA, was not processed by caspase-7. The caspase-7-mediated generation and release of mature EMAP II may provide a mechanism for leukocyte recruitment to sites of programmed cell death, and thus may link apoptosis to inflammation. Copyright (C) 2000 Federation of European Biochemical Societies.

AB - Endothelial monocyte-activating polypeptide II (EMAP II) is a proinflammatory cytokine and a chemoattractant for leukocytes. The mature cytokine is formed in apoptotic cells by cleavage of the precursor proEMAP II. Here we show that caspase-7 is capable of cleaving proEMAP II in vitro. A proEMAP II mutant, in which the ASTD cleavage site was changed to the sequence ASTA, was not processed by caspase-7. The caspase-7-mediated generation and release of mature EMAP II may provide a mechanism for leukocyte recruitment to sites of programmed cell death, and thus may link apoptosis to inflammation. Copyright (C) 2000 Federation of European Biochemical Societies.

KW - Apoptosis

KW - Caspase-7

KW - Endothelial monocyte-activating polypeptide II

KW - Leukocyte recruitment

UR - http://www.scopus.com/inward/record.url?scp=0033984016&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033984016&partnerID=8YFLogxK

U2 - 10.1016/S0014-5793(99)01777-9

DO - 10.1016/S0014-5793(99)01777-9

M3 - Article

C2 - 10648830

AN - SCOPUS:0033984016

VL - 466

SP - 143

EP - 147

JO - FEBS Letters

JF - FEBS Letters

SN - 0014-5793

IS - 1

ER -