The endothelial monocyte-activating polypeptide II (EMAP II) is a substrate for caspase-7

Heike A. Behrensdorf, Marc Van De Craen, Ulrike E. Knies, Peter Vandenabeele, Matthias Clauss

Research output: Contribution to journalArticlepeer-review

64 Scopus citations

Abstract

Endothelial monocyte-activating polypeptide II (EMAP II) is a proinflammatory cytokine and a chemoattractant for leukocytes. The mature cytokine is formed in apoptotic cells by cleavage of the precursor proEMAP II. Here we show that caspase-7 is capable of cleaving proEMAP II in vitro. A proEMAP II mutant, in which the ASTD cleavage site was changed to the sequence ASTA, was not processed by caspase-7. The caspase-7-mediated generation and release of mature EMAP II may provide a mechanism for leukocyte recruitment to sites of programmed cell death, and thus may link apoptosis to inflammation. Copyright (C) 2000 Federation of European Biochemical Societies.

Original languageEnglish (US)
Pages (from-to)143-147
Number of pages5
JournalFEBS Letters
Volume466
Issue number1
DOIs
StatePublished - Jan 21 2000

Keywords

  • Apoptosis
  • Caspase-7
  • Endothelial monocyte-activating polypeptide II
  • Leukocyte recruitment

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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