The ENIGMA Consortium

Large-scale collaborative analyses of neuroimaging and genetic data

Paul M. Thompson, Jason L. Stein, Sarah E. Medland, Derrek P. Hibar, Alejandro Arias Vasquez, Miguel E. Renteria, Roberto Toro, Neda Jahanshad, Gunter Schumann, Barbara Franke, Margaret J. Wright, Nicholas G. Martin, Ingrid Agartz, Martin Alda, Saud Alhusaini, Laura Almasy, Jorge Almeida, Kathryn Alpert, Nancy C. Andreasen, Ole A. Andreassen & 269 others Liana G. Apostolova, Katja Appel, Nicola J. Armstrong, Benjamin Aribisala, Mark E. Bastin, Michael Bauer, Carrie E. Bearden, Ørjan Bergmann, Elisabeth B. Binder, John Blangero, Henry J. Bockholt, Erlend Bøen, Catherine Bois, Dorret I. Boomsma, Tom Booth, Ian J. Bowman, Janita Bralten, Rachel M. Brouwer, Han G. Brunner, David G. Brohawn, Randy L. Buckner, Jan Buitelaar, Kazima Bulayeva, Juan R. Bustillo, Vince D. Calhoun, Dara M. Cannon, Rita M. Cantor, Melanie A. Carless, Xavier Caseras, Gianpiero L. Cavalleri, M. Mallar Chakravarty, Kiki D. Chang, Christopher R K Ching, Andrea Christoforou, Sven Cichon, Vincent P. Clark, Patricia Conrod, Giovanni Coppola, Benedicto Crespo-Facorro, Joanne E. Curran, Michael Czisch, Ian J. Deary, Eco J C de Geus, Anouk den Braber, Giuseppe Delvecchio, Chantal Depondt, Lieuwe de Haan, Greig I. de Zubicaray, Danai Dima, Rali Dimitrova, Srdjan Djurovic, Hongwei Dong, Gary Donohoe, Ravindranath Duggirala, Thomas D. Dyer, Stefan Ehrlich, Carl Johan Ekman, Torbjørn Elvsåshagen, Louise Emsell, Susanne Erk, Thomas Espeseth, Jesen Fagerness, Scott Fears, Iryna Fedko, Guillén Fernández, Simon E. Fisher, Tatiana Foroud, Peter T. Fox, Clyde Francks, Sophia Frangou, Eva Maria Frey, Thomas Frodl, Vincent Frouin, Hugh Garavan, Sudheer Giddaluru, David C. Glahn, Beata Godlewska, Rita Z. Goldstein, Randy L. Gollub, Hans J. Grabe, Oliver Grimm, Oliver Gruber, Tulio Guadalupe, Raquel E. Gur, Ruben C. Gur, Harald H H Göring, Saskia Hagenaars, Tomas Hajek, Geoffrey B. Hall, Jeremy Hall, John Hardy, Catharina A. Hartman, Johanna Hass, Sean N. Hatton, Unn K. Haukvik, Katrin Hegenscheid, Andreas Heinz, Ian B. Hickie, Beng Choon Ho, David Hoehn, Pieter J. Hoekstra, Marisa Hollinshead, Avram J. Holmes, Georg Homuth, Martine Hoogman, L. Elliot Hong, Norbert Hosten, Jouke Jan Hottenga, Hilleke E. Hulshoff Pol, Kristy S. Hwang, Clifford R. Jack, Mark Jenkinson, Caroline Johnston, Erik G. Jönsson, René S. Kahn, Dalia Kasperaviciute, Sinead Kelly, Sungeun Kim, Peter Kochunov, Laura Koenders, Bernd Krämer, John B J Kwok, Jim Lagopoulos, Gonzalo Laje, Mikael Landen, Bennett A. Landman, John Lauriello, Stephen M. Lawrie, Phil H. Lee, Stephanie Le Hellard, Herve Lemaître, Cassandra D. Leonardo, Chiang shan Li, Benny Liberg, David C. Liewald, Xinmin Liu, Lorna M. Lopez, Eva Loth, Anbarasu Lourdusamy, Michelle Luciano, Fabio Macciardi, Marise W J Machielsen, Glenda M. MacQueen, Ulrik F. Malt, René Mandl, Dara S. Manoach, Jean Luc Martinot, Mar Matarin, Karen A. Mather, Manuel Mattheisen, Morten Mattingsdal, Andreas Meyer-Lindenberg, Colm McDonald, Andrew M. McIntosh, Francis J. McMahon, Katie L. McMahon, Eva Meisenzahl, Ingrid Melle, Yuri Milaneschi, Sebastian Mohnke, Grant W. Montgomery, Derek W. Morris, Eric K. Moses, Bryon A. Mueller, Susana Muñoz Maniega, Thomas W. Mühleisen, Bertram Müller-Myhsok, Benson Mwangi, Matthias Nauck, Kwangsik Nho, Thomas E. Nichols, Lars Göran Nilsson, Allison C. Nugent, Lars Nyberg, Rene L. Olvera, Jaap Oosterlaan, Roel A. Ophoff, Massimo Pandolfo, Melina Papalampropoulou-Tsiridou, Martina Papmeyer, Tomas Paus, Zdenka Pausova, Godfrey D. Pearlson, Brenda W. Penninx, Charles P. Peterson, Andrea Pfennig, Mary Phillips, G. Bruce Pike, Jean Baptiste Poline, Steven G. Potkin, Benno Pütz, Adaikalavan Ramasamy, Jerod Rasmussen, Marcella Rietschel, Mark Rijpkema, Shannon L. Risacher, Joshua L. Roffman, Roberto Roiz-Santiañez, Nina Romanczuk-Seiferth, Emma J. Rose, Natalie A. Royle, Dan Rujescu, Mina Ryten, Perminder S. Sachdev, Alireza Salami, Theodore D. Satterthwaite, Jonathan Savitz, Andrew Saykin, Cathy Scanlon, Lianne Schmaal, Hugo G. Schnack, Andrew J. Schork, S. Charles Schulz, Remmelt Schür, Larry Seidman, Li Shen, Jody M. Shoemaker, Andrew Simmons, Sanjay M. Sisodiya, Colin Smith, Jordan W. Smoller, Jair C. Soares, Scott R. Sponheim, Emma Sprooten, John M. Starr, Vidar M. Steen, Stephen Strakowski, Lachlan Strike, Jessika Sussmann, Philipp G. Sämann, Alexander Teumer, Arthur W. Toga, Diana Tordesillas-Gutierrez, Daniah Trabzuni, Sarah Trost, Jessica Turner, Martijn Van den Heuvel, Nic J. van der Wee, Kristel van Eijk, Theo G M van Erp, Neeltje E M van Haren, Dennis van 't Ent, Marie Jose van Tol, Maria C. Valdés Hernández, Dick J. Veltman, Amelia Versace, Henry Völzke, Robert Walker, Henrik Walter, Lei Wang, Joanna M. Wardlaw, Michael E. Weale, Michael W. Weiner, Wei Wen, Lars T. Westlye, Heather C. Whalley, Christopher D. Whelan, Tonya White, Anderson M. Winkler, Katharina Wittfeld, Girma Woldehawariat, Christiane Wolf, David Zilles, Marcel P. Zwiers, Anbupalam Thalamuthu, Peter R. Schofield, Nelson B. Freimer, Natalia S. Lawrence, Wayne Drevets

Research output: Contribution to journalArticle

264 Citations (Scopus)

Abstract

The Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) Consortium is a collaborative network of researchers working together on a range of large-scale studies that integrate data from 70 institutions worldwide. Organized into Working Groups that tackle questions in neuroscience, genetics, and medicine, ENIGMA studies have analyzed neuroimaging data from over 12,826 subjects. In addition, data from 12,171 individuals were provided by the CHARGE consortium for replication of findings, in a total of 24,997 subjects. By meta-analyzing results from many sites, ENIGMA has detected factors that affect the brain that no individual site could detect on its own, and that require larger numbers of subjects than any individual neuroimaging study has currently collected. ENIGMA's first project was a genome-wide association study identifying common variants in the genome associated with hippocampal volume or intracranial volume. Continuing work is exploring genetic associations with subcortical volumes (ENIGMA2) and white matter microstructure (ENIGMA-DTI). Working groups also focus on understanding how schizophrenia, bipolar illness, major depression and attention deficit/hyperactivity disorder (ADHD) affect the brain. We review the current progress of the ENIGMA Consortium, along with challenges and unexpected discoveries made on the way.

Original languageEnglish
Pages (from-to)153-182
Number of pages30
JournalBrain Imaging and Behavior
Volume8
Issue number2
DOIs
StatePublished - 2014

Fingerprint

Neuroimaging
Meta-Analysis
Genome-Wide Association Study
Brain
Attention Deficit Disorder with Hyperactivity
Neurosciences
Focus Groups
Schizophrenia
Research Personnel
Medicine
Genome
Depression

Keywords

  • Consortium
  • Genetics
  • GWAS
  • Meta-analysis
  • MRI
  • Multi-site

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Behavioral Neuroscience
  • Cellular and Molecular Neuroscience
  • Cognitive Neuroscience
  • Neurology
  • Psychiatry and Mental health
  • Clinical Neurology

Cite this

Thompson, P. M., Stein, J. L., Medland, S. E., Hibar, D. P., Vasquez, A. A., Renteria, M. E., ... Drevets, W. (2014). The ENIGMA Consortium: Large-scale collaborative analyses of neuroimaging and genetic data. Brain Imaging and Behavior, 8(2), 153-182. https://doi.org/10.1007/s11682-013-9269-5

The ENIGMA Consortium : Large-scale collaborative analyses of neuroimaging and genetic data. / Thompson, Paul M.; Stein, Jason L.; Medland, Sarah E.; Hibar, Derrek P.; Vasquez, Alejandro Arias; Renteria, Miguel E.; Toro, Roberto; Jahanshad, Neda; Schumann, Gunter; Franke, Barbara; Wright, Margaret J.; Martin, Nicholas G.; Agartz, Ingrid; Alda, Martin; Alhusaini, Saud; Almasy, Laura; Almeida, Jorge; Alpert, Kathryn; Andreasen, Nancy C.; Andreassen, Ole A.; Apostolova, Liana G.; Appel, Katja; Armstrong, Nicola J.; Aribisala, Benjamin; Bastin, Mark E.; Bauer, Michael; Bearden, Carrie E.; Bergmann, Ørjan; Binder, Elisabeth B.; Blangero, John; Bockholt, Henry J.; Bøen, Erlend; Bois, Catherine; Boomsma, Dorret I.; Booth, Tom; Bowman, Ian J.; Bralten, Janita; Brouwer, Rachel M.; Brunner, Han G.; Brohawn, David G.; Buckner, Randy L.; Buitelaar, Jan; Bulayeva, Kazima; Bustillo, Juan R.; Calhoun, Vince D.; Cannon, Dara M.; Cantor, Rita M.; Carless, Melanie A.; Caseras, Xavier; Cavalleri, Gianpiero L.; Chakravarty, M. Mallar; Chang, Kiki D.; Ching, Christopher R K; Christoforou, Andrea; Cichon, Sven; Clark, Vincent P.; Conrod, Patricia; Coppola, Giovanni; Crespo-Facorro, Benedicto; Curran, Joanne E.; Czisch, Michael; Deary, Ian J.; de Geus, Eco J C; den Braber, Anouk; Delvecchio, Giuseppe; Depondt, Chantal; de Haan, Lieuwe; de Zubicaray, Greig I.; Dima, Danai; Dimitrova, Rali; Djurovic, Srdjan; Dong, Hongwei; Donohoe, Gary; Duggirala, Ravindranath; Dyer, Thomas D.; Ehrlich, Stefan; Ekman, Carl Johan; Elvsåshagen, Torbjørn; Emsell, Louise; Erk, Susanne; Espeseth, Thomas; Fagerness, Jesen; Fears, Scott; Fedko, Iryna; Fernández, Guillén; Fisher, Simon E.; Foroud, Tatiana; Fox, Peter T.; Francks, Clyde; Frangou, Sophia; Frey, Eva Maria; Frodl, Thomas; Frouin, Vincent; Garavan, Hugh; Giddaluru, Sudheer; Glahn, David C.; Godlewska, Beata; Goldstein, Rita Z.; Gollub, Randy L.; Grabe, Hans J.; Grimm, Oliver; Gruber, Oliver; Guadalupe, Tulio; Gur, Raquel E.; Gur, Ruben C.; Göring, Harald H H; Hagenaars, Saskia; Hajek, Tomas; Hall, Geoffrey B.; Hall, Jeremy; Hardy, John; Hartman, Catharina A.; Hass, Johanna; Hatton, Sean N.; Haukvik, Unn K.; Hegenscheid, Katrin; Heinz, Andreas; Hickie, Ian B.; Ho, Beng Choon; Hoehn, David; Hoekstra, Pieter J.; Hollinshead, Marisa; Holmes, Avram J.; Homuth, Georg; Hoogman, Martine; Hong, L. Elliot; Hosten, Norbert; Hottenga, Jouke Jan; Hulshoff Pol, Hilleke E.; Hwang, Kristy S.; Jack, Clifford R.; Jenkinson, Mark; Johnston, Caroline; Jönsson, Erik G.; Kahn, René S.; Kasperaviciute, Dalia; Kelly, Sinead; Kim, Sungeun; Kochunov, Peter; Koenders, Laura; Krämer, Bernd; Kwok, John B J; Lagopoulos, Jim; Laje, Gonzalo; Landen, Mikael; Landman, Bennett A.; Lauriello, John; Lawrie, Stephen M.; Lee, Phil H.; Le Hellard, Stephanie; Lemaître, Herve; Leonardo, Cassandra D.; Li, Chiang shan; Liberg, Benny; Liewald, David C.; Liu, Xinmin; Lopez, Lorna M.; Loth, Eva; Lourdusamy, Anbarasu; Luciano, Michelle; Macciardi, Fabio; Machielsen, Marise W J; MacQueen, Glenda M.; Malt, Ulrik F.; Mandl, René; Manoach, Dara S.; Martinot, Jean Luc; Matarin, Mar; Mather, Karen A.; Mattheisen, Manuel; Mattingsdal, Morten; Meyer-Lindenberg, Andreas; McDonald, Colm; McIntosh, Andrew M.; McMahon, Francis J.; McMahon, Katie L.; Meisenzahl, Eva; Melle, Ingrid; Milaneschi, Yuri; Mohnke, Sebastian; Montgomery, Grant W.; Morris, Derek W.; Moses, Eric K.; Mueller, Bryon A.; Muñoz Maniega, Susana; Mühleisen, Thomas W.; Müller-Myhsok, Bertram; Mwangi, Benson; Nauck, Matthias; Nho, Kwangsik; Nichols, Thomas E.; Nilsson, Lars Göran; Nugent, Allison C.; Nyberg, Lars; Olvera, Rene L.; Oosterlaan, Jaap; Ophoff, Roel A.; Pandolfo, Massimo; Papalampropoulou-Tsiridou, Melina; Papmeyer, Martina; Paus, Tomas; Pausova, Zdenka; Pearlson, Godfrey D.; Penninx, Brenda W.; Peterson, Charles P.; Pfennig, Andrea; Phillips, Mary; Pike, G. Bruce; Poline, Jean Baptiste; Potkin, Steven G.; Pütz, Benno; Ramasamy, Adaikalavan; Rasmussen, Jerod; Rietschel, Marcella; Rijpkema, Mark; Risacher, Shannon L.; Roffman, Joshua L.; Roiz-Santiañez, Roberto; Romanczuk-Seiferth, Nina; Rose, Emma J.; Royle, Natalie A.; Rujescu, Dan; Ryten, Mina; Sachdev, Perminder S.; Salami, Alireza; Satterthwaite, Theodore D.; Savitz, Jonathan; Saykin, Andrew; Scanlon, Cathy; Schmaal, Lianne; Schnack, Hugo G.; Schork, Andrew J.; Schulz, S. Charles; Schür, Remmelt; Seidman, Larry; Shen, Li; Shoemaker, Jody M.; Simmons, Andrew; Sisodiya, Sanjay M.; Smith, Colin; Smoller, Jordan W.; Soares, Jair C.; Sponheim, Scott R.; Sprooten, Emma; Starr, John M.; Steen, Vidar M.; Strakowski, Stephen; Strike, Lachlan; Sussmann, Jessika; Sämann, Philipp G.; Teumer, Alexander; Toga, Arthur W.; Tordesillas-Gutierrez, Diana; Trabzuni, Daniah; Trost, Sarah; Turner, Jessica; Van den Heuvel, Martijn; van der Wee, Nic J.; van Eijk, Kristel; van Erp, Theo G M; van Haren, Neeltje E M; van 't Ent, Dennis; van Tol, Marie Jose; Valdés Hernández, Maria C.; Veltman, Dick J.; Versace, Amelia; Völzke, Henry; Walker, Robert; Walter, Henrik; Wang, Lei; Wardlaw, Joanna M.; Weale, Michael E.; Weiner, Michael W.; Wen, Wei; Westlye, Lars T.; Whalley, Heather C.; Whelan, Christopher D.; White, Tonya; Winkler, Anderson M.; Wittfeld, Katharina; Woldehawariat, Girma; Wolf, Christiane; Zilles, David; Zwiers, Marcel P.; Thalamuthu, Anbupalam; Schofield, Peter R.; Freimer, Nelson B.; Lawrence, Natalia S.; Drevets, Wayne.

In: Brain Imaging and Behavior, Vol. 8, No. 2, 2014, p. 153-182.

Research output: Contribution to journalArticle

Thompson, PM, Stein, JL, Medland, SE, Hibar, DP, Vasquez, AA, Renteria, ME, Toro, R, Jahanshad, N, Schumann, G, Franke, B, Wright, MJ, Martin, NG, Agartz, I, Alda, M, Alhusaini, S, Almasy, L, Almeida, J, Alpert, K, Andreasen, NC, Andreassen, OA, Apostolova, LG, Appel, K, Armstrong, NJ, Aribisala, B, Bastin, ME, Bauer, M, Bearden, CE, Bergmann, Ø, Binder, EB, Blangero, J, Bockholt, HJ, Bøen, E, Bois, C, Boomsma, DI, Booth, T, Bowman, IJ, Bralten, J, Brouwer, RM, Brunner, HG, Brohawn, DG, Buckner, RL, Buitelaar, J, Bulayeva, K, Bustillo, JR, Calhoun, VD, Cannon, DM, Cantor, RM, Carless, MA, Caseras, X, Cavalleri, GL, Chakravarty, MM, Chang, KD, Ching, CRK, Christoforou, A, Cichon, S, Clark, VP, Conrod, P, Coppola, G, Crespo-Facorro, B, Curran, JE, Czisch, M, Deary, IJ, de Geus, EJC, den Braber, A, Delvecchio, G, Depondt, C, de Haan, L, de Zubicaray, GI, Dima, D, Dimitrova, R, Djurovic, S, Dong, H, Donohoe, G, Duggirala, R, Dyer, TD, Ehrlich, S, Ekman, CJ, Elvsåshagen, T, Emsell, L, Erk, S, Espeseth, T, Fagerness, J, Fears, S, Fedko, I, Fernández, G, Fisher, SE, Foroud, T, Fox, PT, Francks, C, Frangou, S, Frey, EM, Frodl, T, Frouin, V, Garavan, H, Giddaluru, S, Glahn, DC, Godlewska, B, Goldstein, RZ, Gollub, RL, Grabe, HJ, Grimm, O, Gruber, O, Guadalupe, T, Gur, RE, Gur, RC, Göring, HHH, Hagenaars, S, Hajek, T, Hall, GB, Hall, J, Hardy, J, Hartman, CA, Hass, J, Hatton, SN, Haukvik, UK, Hegenscheid, K, Heinz, A, Hickie, IB, Ho, BC, Hoehn, D, Hoekstra, PJ, Hollinshead, M, Holmes, AJ, Homuth, G, Hoogman, M, Hong, LE, Hosten, N, Hottenga, JJ, Hulshoff Pol, HE, Hwang, KS, Jack, CR, Jenkinson, M, Johnston, C, Jönsson, EG, Kahn, RS, Kasperaviciute, D, Kelly, S, Kim, S, Kochunov, P, Koenders, L, Krämer, B, Kwok, JBJ, Lagopoulos, J, Laje, G, Landen, M, Landman, BA, Lauriello, J, Lawrie, SM, Lee, PH, Le Hellard, S, Lemaître, H, Leonardo, CD, Li, CS, Liberg, B, Liewald, DC, Liu, X, Lopez, LM, Loth, E, Lourdusamy, A, Luciano, M, Macciardi, F, Machielsen, MWJ, MacQueen, GM, Malt, UF, Mandl, R, Manoach, DS, Martinot, JL, Matarin, M, Mather, KA, Mattheisen, M, Mattingsdal, M, Meyer-Lindenberg, A, McDonald, C, McIntosh, AM, McMahon, FJ, McMahon, KL, Meisenzahl, E, Melle, I, Milaneschi, Y, Mohnke, S, Montgomery, GW, Morris, DW, Moses, EK, Mueller, BA, Muñoz Maniega, S, Mühleisen, TW, Müller-Myhsok, B, Mwangi, B, Nauck, M, Nho, K, Nichols, TE, Nilsson, LG, Nugent, AC, Nyberg, L, Olvera, RL, Oosterlaan, J, Ophoff, RA, Pandolfo, M, Papalampropoulou-Tsiridou, M, Papmeyer, M, Paus, T, Pausova, Z, Pearlson, GD, Penninx, BW, Peterson, CP, Pfennig, A, Phillips, M, Pike, GB, Poline, JB, Potkin, SG, Pütz, B, Ramasamy, A, Rasmussen, J, Rietschel, M, Rijpkema, M, Risacher, SL, Roffman, JL, Roiz-Santiañez, R, Romanczuk-Seiferth, N, Rose, EJ, Royle, NA, Rujescu, D, Ryten, M, Sachdev, PS, Salami, A, Satterthwaite, TD, Savitz, J, Saykin, A, Scanlon, C, Schmaal, L, Schnack, HG, Schork, AJ, Schulz, SC, Schür, R, Seidman, L, Shen, L, Shoemaker, JM, Simmons, A, Sisodiya, SM, Smith, C, Smoller, JW, Soares, JC, Sponheim, SR, Sprooten, E, Starr, JM, Steen, VM, Strakowski, S, Strike, L, Sussmann, J, Sämann, PG, Teumer, A, Toga, AW, Tordesillas-Gutierrez, D, Trabzuni, D, Trost, S, Turner, J, Van den Heuvel, M, van der Wee, NJ, van Eijk, K, van Erp, TGM, van Haren, NEM, van 't Ent, D, van Tol, MJ, Valdés Hernández, MC, Veltman, DJ, Versace, A, Völzke, H, Walker, R, Walter, H, Wang, L, Wardlaw, JM, Weale, ME, Weiner, MW, Wen, W, Westlye, LT, Whalley, HC, Whelan, CD, White, T, Winkler, AM, Wittfeld, K, Woldehawariat, G, Wolf, C, Zilles, D, Zwiers, MP, Thalamuthu, A, Schofield, PR, Freimer, NB, Lawrence, NS & Drevets, W 2014, 'The ENIGMA Consortium: Large-scale collaborative analyses of neuroimaging and genetic data', Brain Imaging and Behavior, vol. 8, no. 2, pp. 153-182. https://doi.org/10.1007/s11682-013-9269-5
Thompson, Paul M. ; Stein, Jason L. ; Medland, Sarah E. ; Hibar, Derrek P. ; Vasquez, Alejandro Arias ; Renteria, Miguel E. ; Toro, Roberto ; Jahanshad, Neda ; Schumann, Gunter ; Franke, Barbara ; Wright, Margaret J. ; Martin, Nicholas G. ; Agartz, Ingrid ; Alda, Martin ; Alhusaini, Saud ; Almasy, Laura ; Almeida, Jorge ; Alpert, Kathryn ; Andreasen, Nancy C. ; Andreassen, Ole A. ; Apostolova, Liana G. ; Appel, Katja ; Armstrong, Nicola J. ; Aribisala, Benjamin ; Bastin, Mark E. ; Bauer, Michael ; Bearden, Carrie E. ; Bergmann, Ørjan ; Binder, Elisabeth B. ; Blangero, John ; Bockholt, Henry J. ; Bøen, Erlend ; Bois, Catherine ; Boomsma, Dorret I. ; Booth, Tom ; Bowman, Ian J. ; Bralten, Janita ; Brouwer, Rachel M. ; Brunner, Han G. ; Brohawn, David G. ; Buckner, Randy L. ; Buitelaar, Jan ; Bulayeva, Kazima ; Bustillo, Juan R. ; Calhoun, Vince D. ; Cannon, Dara M. ; Cantor, Rita M. ; Carless, Melanie A. ; Caseras, Xavier ; Cavalleri, Gianpiero L. ; Chakravarty, M. Mallar ; Chang, Kiki D. ; Ching, Christopher R K ; Christoforou, Andrea ; Cichon, Sven ; Clark, Vincent P. ; Conrod, Patricia ; Coppola, Giovanni ; Crespo-Facorro, Benedicto ; Curran, Joanne E. ; Czisch, Michael ; Deary, Ian J. ; de Geus, Eco J C ; den Braber, Anouk ; Delvecchio, Giuseppe ; Depondt, Chantal ; de Haan, Lieuwe ; de Zubicaray, Greig I. ; Dima, Danai ; Dimitrova, Rali ; Djurovic, Srdjan ; Dong, Hongwei ; Donohoe, Gary ; Duggirala, Ravindranath ; Dyer, Thomas D. ; Ehrlich, Stefan ; Ekman, Carl Johan ; Elvsåshagen, Torbjørn ; Emsell, Louise ; Erk, Susanne ; Espeseth, Thomas ; Fagerness, Jesen ; Fears, Scott ; Fedko, Iryna ; Fernández, Guillén ; Fisher, Simon E. ; Foroud, Tatiana ; Fox, Peter T. ; Francks, Clyde ; Frangou, Sophia ; Frey, Eva Maria ; Frodl, Thomas ; Frouin, Vincent ; Garavan, Hugh ; Giddaluru, Sudheer ; Glahn, David C. ; Godlewska, Beata ; Goldstein, Rita Z. ; Gollub, Randy L. ; Grabe, Hans J. ; Grimm, Oliver ; Gruber, Oliver ; Guadalupe, Tulio ; Gur, Raquel E. ; Gur, Ruben C. ; Göring, Harald H H ; Hagenaars, Saskia ; Hajek, Tomas ; Hall, Geoffrey B. ; Hall, Jeremy ; Hardy, John ; Hartman, Catharina A. ; Hass, Johanna ; Hatton, Sean N. ; Haukvik, Unn K. ; Hegenscheid, Katrin ; Heinz, Andreas ; Hickie, Ian B. ; Ho, Beng Choon ; Hoehn, David ; Hoekstra, Pieter J. ; Hollinshead, Marisa ; Holmes, Avram J. ; Homuth, Georg ; Hoogman, Martine ; Hong, L. Elliot ; Hosten, Norbert ; Hottenga, Jouke Jan ; Hulshoff Pol, Hilleke E. ; Hwang, Kristy S. ; Jack, Clifford R. ; Jenkinson, Mark ; Johnston, Caroline ; Jönsson, Erik G. ; Kahn, René S. ; Kasperaviciute, Dalia ; Kelly, Sinead ; Kim, Sungeun ; Kochunov, Peter ; Koenders, Laura ; Krämer, Bernd ; Kwok, John B J ; Lagopoulos, Jim ; Laje, Gonzalo ; Landen, Mikael ; Landman, Bennett A. ; Lauriello, John ; Lawrie, Stephen M. ; Lee, Phil H. ; Le Hellard, Stephanie ; Lemaître, Herve ; Leonardo, Cassandra D. ; Li, Chiang shan ; Liberg, Benny ; Liewald, David C. ; Liu, Xinmin ; Lopez, Lorna M. ; Loth, Eva ; Lourdusamy, Anbarasu ; Luciano, Michelle ; Macciardi, Fabio ; Machielsen, Marise W J ; MacQueen, Glenda M. ; Malt, Ulrik F. ; Mandl, René ; Manoach, Dara S. ; Martinot, Jean Luc ; Matarin, Mar ; Mather, Karen A. ; Mattheisen, Manuel ; Mattingsdal, Morten ; Meyer-Lindenberg, Andreas ; McDonald, Colm ; McIntosh, Andrew M. ; McMahon, Francis J. ; McMahon, Katie L. ; Meisenzahl, Eva ; Melle, Ingrid ; Milaneschi, Yuri ; Mohnke, Sebastian ; Montgomery, Grant W. ; Morris, Derek W. ; Moses, Eric K. ; Mueller, Bryon A. ; Muñoz Maniega, Susana ; Mühleisen, Thomas W. ; Müller-Myhsok, Bertram ; Mwangi, Benson ; Nauck, Matthias ; Nho, Kwangsik ; Nichols, Thomas E. ; Nilsson, Lars Göran ; Nugent, Allison C. ; Nyberg, Lars ; Olvera, Rene L. ; Oosterlaan, Jaap ; Ophoff, Roel A. ; Pandolfo, Massimo ; Papalampropoulou-Tsiridou, Melina ; Papmeyer, Martina ; Paus, Tomas ; Pausova, Zdenka ; Pearlson, Godfrey D. ; Penninx, Brenda W. ; Peterson, Charles P. ; Pfennig, Andrea ; Phillips, Mary ; Pike, G. Bruce ; Poline, Jean Baptiste ; Potkin, Steven G. ; Pütz, Benno ; Ramasamy, Adaikalavan ; Rasmussen, Jerod ; Rietschel, Marcella ; Rijpkema, Mark ; Risacher, Shannon L. ; Roffman, Joshua L. ; Roiz-Santiañez, Roberto ; Romanczuk-Seiferth, Nina ; Rose, Emma J. ; Royle, Natalie A. ; Rujescu, Dan ; Ryten, Mina ; Sachdev, Perminder S. ; Salami, Alireza ; Satterthwaite, Theodore D. ; Savitz, Jonathan ; Saykin, Andrew ; Scanlon, Cathy ; Schmaal, Lianne ; Schnack, Hugo G. ; Schork, Andrew J. ; Schulz, S. Charles ; Schür, Remmelt ; Seidman, Larry ; Shen, Li ; Shoemaker, Jody M. ; Simmons, Andrew ; Sisodiya, Sanjay M. ; Smith, Colin ; Smoller, Jordan W. ; Soares, Jair C. ; Sponheim, Scott R. ; Sprooten, Emma ; Starr, John M. ; Steen, Vidar M. ; Strakowski, Stephen ; Strike, Lachlan ; Sussmann, Jessika ; Sämann, Philipp G. ; Teumer, Alexander ; Toga, Arthur W. ; Tordesillas-Gutierrez, Diana ; Trabzuni, Daniah ; Trost, Sarah ; Turner, Jessica ; Van den Heuvel, Martijn ; van der Wee, Nic J. ; van Eijk, Kristel ; van Erp, Theo G M ; van Haren, Neeltje E M ; van 't Ent, Dennis ; van Tol, Marie Jose ; Valdés Hernández, Maria C. ; Veltman, Dick J. ; Versace, Amelia ; Völzke, Henry ; Walker, Robert ; Walter, Henrik ; Wang, Lei ; Wardlaw, Joanna M. ; Weale, Michael E. ; Weiner, Michael W. ; Wen, Wei ; Westlye, Lars T. ; Whalley, Heather C. ; Whelan, Christopher D. ; White, Tonya ; Winkler, Anderson M. ; Wittfeld, Katharina ; Woldehawariat, Girma ; Wolf, Christiane ; Zilles, David ; Zwiers, Marcel P. ; Thalamuthu, Anbupalam ; Schofield, Peter R. ; Freimer, Nelson B. ; Lawrence, Natalia S. ; Drevets, Wayne. / The ENIGMA Consortium : Large-scale collaborative analyses of neuroimaging and genetic data. In: Brain Imaging and Behavior. 2014 ; Vol. 8, No. 2. pp. 153-182.
@article{ccf4267507f24564a1eb47e32f471337,
title = "The ENIGMA Consortium: Large-scale collaborative analyses of neuroimaging and genetic data",
abstract = "The Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) Consortium is a collaborative network of researchers working together on a range of large-scale studies that integrate data from 70 institutions worldwide. Organized into Working Groups that tackle questions in neuroscience, genetics, and medicine, ENIGMA studies have analyzed neuroimaging data from over 12,826 subjects. In addition, data from 12,171 individuals were provided by the CHARGE consortium for replication of findings, in a total of 24,997 subjects. By meta-analyzing results from many sites, ENIGMA has detected factors that affect the brain that no individual site could detect on its own, and that require larger numbers of subjects than any individual neuroimaging study has currently collected. ENIGMA's first project was a genome-wide association study identifying common variants in the genome associated with hippocampal volume or intracranial volume. Continuing work is exploring genetic associations with subcortical volumes (ENIGMA2) and white matter microstructure (ENIGMA-DTI). Working groups also focus on understanding how schizophrenia, bipolar illness, major depression and attention deficit/hyperactivity disorder (ADHD) affect the brain. We review the current progress of the ENIGMA Consortium, along with challenges and unexpected discoveries made on the way.",
keywords = "Consortium, Genetics, GWAS, Meta-analysis, MRI, Multi-site",
author = "Thompson, {Paul M.} and Stein, {Jason L.} and Medland, {Sarah E.} and Hibar, {Derrek P.} and Vasquez, {Alejandro Arias} and Renteria, {Miguel E.} and Roberto Toro and Neda Jahanshad and Gunter Schumann and Barbara Franke and Wright, {Margaret J.} and Martin, {Nicholas G.} and Ingrid Agartz and Martin Alda and Saud Alhusaini and Laura Almasy and Jorge Almeida and Kathryn Alpert and Andreasen, {Nancy C.} and Andreassen, {Ole A.} and Apostolova, {Liana G.} and Katja Appel and Armstrong, {Nicola J.} and Benjamin Aribisala and Bastin, {Mark E.} and Michael Bauer and Bearden, {Carrie E.} and {\O}rjan Bergmann and Binder, {Elisabeth B.} and John Blangero and Bockholt, {Henry J.} and Erlend B{\o}en and Catherine Bois and Boomsma, {Dorret I.} and Tom Booth and Bowman, {Ian J.} and Janita Bralten and Brouwer, {Rachel M.} and Brunner, {Han G.} and Brohawn, {David G.} and Buckner, {Randy L.} and Jan Buitelaar and Kazima Bulayeva and Bustillo, {Juan R.} and Calhoun, {Vince D.} and Cannon, {Dara M.} and Cantor, {Rita M.} and Carless, {Melanie A.} and Xavier Caseras and Cavalleri, {Gianpiero L.} and Chakravarty, {M. Mallar} and Chang, {Kiki D.} and Ching, {Christopher R K} and Andrea Christoforou and Sven Cichon and Clark, {Vincent P.} and Patricia Conrod and Giovanni Coppola and Benedicto Crespo-Facorro and Curran, {Joanne E.} and Michael Czisch and Deary, {Ian J.} and {de Geus}, {Eco J C} and {den Braber}, Anouk and Giuseppe Delvecchio and Chantal Depondt and {de Haan}, Lieuwe and {de Zubicaray}, {Greig I.} and Danai Dima and Rali Dimitrova and Srdjan Djurovic and Hongwei Dong and Gary Donohoe and Ravindranath Duggirala and Dyer, {Thomas D.} and Stefan Ehrlich and Ekman, {Carl Johan} and Torbj{\o}rn Elvs{\aa}shagen and Louise Emsell and Susanne Erk and Thomas Espeseth and Jesen Fagerness and Scott Fears and Iryna Fedko and Guill{\'e}n Fern{\'a}ndez and Fisher, {Simon E.} and Tatiana Foroud and Fox, {Peter T.} and Clyde Francks and Sophia Frangou and Frey, {Eva Maria} and Thomas Frodl and Vincent Frouin and Hugh Garavan and Sudheer Giddaluru and Glahn, {David C.} and Beata Godlewska and Goldstein, {Rita Z.} and Gollub, {Randy L.} and Grabe, {Hans J.} and Oliver Grimm and Oliver Gruber and Tulio Guadalupe and Gur, {Raquel E.} and Gur, {Ruben C.} and G{\"o}ring, {Harald H H} and Saskia Hagenaars and Tomas Hajek and Hall, {Geoffrey B.} and Jeremy Hall and John Hardy and Hartman, {Catharina A.} and Johanna Hass and Hatton, {Sean N.} and Haukvik, {Unn K.} and Katrin Hegenscheid and Andreas Heinz and Hickie, {Ian B.} and Ho, {Beng Choon} and David Hoehn and Hoekstra, {Pieter J.} and Marisa Hollinshead and Holmes, {Avram J.} and Georg Homuth and Martine Hoogman and Hong, {L. Elliot} and Norbert Hosten and Hottenga, {Jouke Jan} and {Hulshoff Pol}, {Hilleke E.} and Hwang, {Kristy S.} and Jack, {Clifford R.} and Mark Jenkinson and Caroline Johnston and J{\"o}nsson, {Erik G.} and Kahn, {Ren{\'e} S.} and Dalia Kasperaviciute and Sinead Kelly and Sungeun Kim and Peter Kochunov and Laura Koenders and Bernd Kr{\"a}mer and Kwok, {John B J} and Jim Lagopoulos and Gonzalo Laje and Mikael Landen and Landman, {Bennett A.} and John Lauriello and Lawrie, {Stephen M.} and Lee, {Phil H.} and {Le Hellard}, Stephanie and Herve Lema{\^i}tre and Leonardo, {Cassandra D.} and Li, {Chiang shan} and Benny Liberg and Liewald, {David C.} and Xinmin Liu and Lopez, {Lorna M.} and Eva Loth and Anbarasu Lourdusamy and Michelle Luciano and Fabio Macciardi and Machielsen, {Marise W J} and MacQueen, {Glenda M.} and Malt, {Ulrik F.} and Ren{\'e} Mandl and Manoach, {Dara S.} and Martinot, {Jean Luc} and Mar Matarin and Mather, {Karen A.} and Manuel Mattheisen and Morten Mattingsdal and Andreas Meyer-Lindenberg and Colm McDonald and McIntosh, {Andrew M.} and McMahon, {Francis J.} and McMahon, {Katie L.} and Eva Meisenzahl and Ingrid Melle and Yuri Milaneschi and Sebastian Mohnke and Montgomery, {Grant W.} and Morris, {Derek W.} and Moses, {Eric K.} and Mueller, {Bryon A.} and {Mu{\~n}oz Maniega}, Susana and M{\"u}hleisen, {Thomas W.} and Bertram M{\"u}ller-Myhsok and Benson Mwangi and Matthias Nauck and Kwangsik Nho and Nichols, {Thomas E.} and Nilsson, {Lars G{\"o}ran} and Nugent, {Allison C.} and Lars Nyberg and Olvera, {Rene L.} and Jaap Oosterlaan and Ophoff, {Roel A.} and Massimo Pandolfo and Melina Papalampropoulou-Tsiridou and Martina Papmeyer and Tomas Paus and Zdenka Pausova and Pearlson, {Godfrey D.} and Penninx, {Brenda W.} and Peterson, {Charles P.} and Andrea Pfennig and Mary Phillips and Pike, {G. Bruce} and Poline, {Jean Baptiste} and Potkin, {Steven G.} and Benno P{\"u}tz and Adaikalavan Ramasamy and Jerod Rasmussen and Marcella Rietschel and Mark Rijpkema and Risacher, {Shannon L.} and Roffman, {Joshua L.} and Roberto Roiz-Santia{\~n}ez and Nina Romanczuk-Seiferth and Rose, {Emma J.} and Royle, {Natalie A.} and Dan Rujescu and Mina Ryten and Sachdev, {Perminder S.} and Alireza Salami and Satterthwaite, {Theodore D.} and Jonathan Savitz and Andrew Saykin and Cathy Scanlon and Lianne Schmaal and Schnack, {Hugo G.} and Schork, {Andrew J.} and Schulz, {S. Charles} and Remmelt Sch{\"u}r and Larry Seidman and Li Shen and Shoemaker, {Jody M.} and Andrew Simmons and Sisodiya, {Sanjay M.} and Colin Smith and Smoller, {Jordan W.} and Soares, {Jair C.} and Sponheim, {Scott R.} and Emma Sprooten and Starr, {John M.} and Steen, {Vidar M.} and Stephen Strakowski and Lachlan Strike and Jessika Sussmann and S{\"a}mann, {Philipp G.} and Alexander Teumer and Toga, {Arthur W.} and Diana Tordesillas-Gutierrez and Daniah Trabzuni and Sarah Trost and Jessica Turner and {Van den Heuvel}, Martijn and {van der Wee}, {Nic J.} and {van Eijk}, Kristel and {van Erp}, {Theo G M} and {van Haren}, {Neeltje E M} and {van 't Ent}, Dennis and {van Tol}, {Marie Jose} and {Vald{\'e}s Hern{\'a}ndez}, {Maria C.} and Veltman, {Dick J.} and Amelia Versace and Henry V{\"o}lzke and Robert Walker and Henrik Walter and Lei Wang and Wardlaw, {Joanna M.} and Weale, {Michael E.} and Weiner, {Michael W.} and Wei Wen and Westlye, {Lars T.} and Whalley, {Heather C.} and Whelan, {Christopher D.} and Tonya White and Winkler, {Anderson M.} and Katharina Wittfeld and Girma Woldehawariat and Christiane Wolf and David Zilles and Zwiers, {Marcel P.} and Anbupalam Thalamuthu and Schofield, {Peter R.} and Freimer, {Nelson B.} and Lawrence, {Natalia S.} and Wayne Drevets",
year = "2014",
doi = "10.1007/s11682-013-9269-5",
language = "English",
volume = "8",
pages = "153--182",
journal = "Brain Imaging and Behavior",
issn = "1931-7557",
publisher = "Springer New York",
number = "2",

}

TY - JOUR

T1 - The ENIGMA Consortium

T2 - Large-scale collaborative analyses of neuroimaging and genetic data

AU - Thompson, Paul M.

AU - Stein, Jason L.

AU - Medland, Sarah E.

AU - Hibar, Derrek P.

AU - Vasquez, Alejandro Arias

AU - Renteria, Miguel E.

AU - Toro, Roberto

AU - Jahanshad, Neda

AU - Schumann, Gunter

AU - Franke, Barbara

AU - Wright, Margaret J.

AU - Martin, Nicholas G.

AU - Agartz, Ingrid

AU - Alda, Martin

AU - Alhusaini, Saud

AU - Almasy, Laura

AU - Almeida, Jorge

AU - Alpert, Kathryn

AU - Andreasen, Nancy C.

AU - Andreassen, Ole A.

AU - Apostolova, Liana G.

AU - Appel, Katja

AU - Armstrong, Nicola J.

AU - Aribisala, Benjamin

AU - Bastin, Mark E.

AU - Bauer, Michael

AU - Bearden, Carrie E.

AU - Bergmann, Ørjan

AU - Binder, Elisabeth B.

AU - Blangero, John

AU - Bockholt, Henry J.

AU - Bøen, Erlend

AU - Bois, Catherine

AU - Boomsma, Dorret I.

AU - Booth, Tom

AU - Bowman, Ian J.

AU - Bralten, Janita

AU - Brouwer, Rachel M.

AU - Brunner, Han G.

AU - Brohawn, David G.

AU - Buckner, Randy L.

AU - Buitelaar, Jan

AU - Bulayeva, Kazima

AU - Bustillo, Juan R.

AU - Calhoun, Vince D.

AU - Cannon, Dara M.

AU - Cantor, Rita M.

AU - Carless, Melanie A.

AU - Caseras, Xavier

AU - Cavalleri, Gianpiero L.

AU - Chakravarty, M. Mallar

AU - Chang, Kiki D.

AU - Ching, Christopher R K

AU - Christoforou, Andrea

AU - Cichon, Sven

AU - Clark, Vincent P.

AU - Conrod, Patricia

AU - Coppola, Giovanni

AU - Crespo-Facorro, Benedicto

AU - Curran, Joanne E.

AU - Czisch, Michael

AU - Deary, Ian J.

AU - de Geus, Eco J C

AU - den Braber, Anouk

AU - Delvecchio, Giuseppe

AU - Depondt, Chantal

AU - de Haan, Lieuwe

AU - de Zubicaray, Greig I.

AU - Dima, Danai

AU - Dimitrova, Rali

AU - Djurovic, Srdjan

AU - Dong, Hongwei

AU - Donohoe, Gary

AU - Duggirala, Ravindranath

AU - Dyer, Thomas D.

AU - Ehrlich, Stefan

AU - Ekman, Carl Johan

AU - Elvsåshagen, Torbjørn

AU - Emsell, Louise

AU - Erk, Susanne

AU - Espeseth, Thomas

AU - Fagerness, Jesen

AU - Fears, Scott

AU - Fedko, Iryna

AU - Fernández, Guillén

AU - Fisher, Simon E.

AU - Foroud, Tatiana

AU - Fox, Peter T.

AU - Francks, Clyde

AU - Frangou, Sophia

AU - Frey, Eva Maria

AU - Frodl, Thomas

AU - Frouin, Vincent

AU - Garavan, Hugh

AU - Giddaluru, Sudheer

AU - Glahn, David C.

AU - Godlewska, Beata

AU - Goldstein, Rita Z.

AU - Gollub, Randy L.

AU - Grabe, Hans J.

AU - Grimm, Oliver

AU - Gruber, Oliver

AU - Guadalupe, Tulio

AU - Gur, Raquel E.

AU - Gur, Ruben C.

AU - Göring, Harald H H

AU - Hagenaars, Saskia

AU - Hajek, Tomas

AU - Hall, Geoffrey B.

AU - Hall, Jeremy

AU - Hardy, John

AU - Hartman, Catharina A.

AU - Hass, Johanna

AU - Hatton, Sean N.

AU - Haukvik, Unn K.

AU - Hegenscheid, Katrin

AU - Heinz, Andreas

AU - Hickie, Ian B.

AU - Ho, Beng Choon

AU - Hoehn, David

AU - Hoekstra, Pieter J.

AU - Hollinshead, Marisa

AU - Holmes, Avram J.

AU - Homuth, Georg

AU - Hoogman, Martine

AU - Hong, L. Elliot

AU - Hosten, Norbert

AU - Hottenga, Jouke Jan

AU - Hulshoff Pol, Hilleke E.

AU - Hwang, Kristy S.

AU - Jack, Clifford R.

AU - Jenkinson, Mark

AU - Johnston, Caroline

AU - Jönsson, Erik G.

AU - Kahn, René S.

AU - Kasperaviciute, Dalia

AU - Kelly, Sinead

AU - Kim, Sungeun

AU - Kochunov, Peter

AU - Koenders, Laura

AU - Krämer, Bernd

AU - Kwok, John B J

AU - Lagopoulos, Jim

AU - Laje, Gonzalo

AU - Landen, Mikael

AU - Landman, Bennett A.

AU - Lauriello, John

AU - Lawrie, Stephen M.

AU - Lee, Phil H.

AU - Le Hellard, Stephanie

AU - Lemaître, Herve

AU - Leonardo, Cassandra D.

AU - Li, Chiang shan

AU - Liberg, Benny

AU - Liewald, David C.

AU - Liu, Xinmin

AU - Lopez, Lorna M.

AU - Loth, Eva

AU - Lourdusamy, Anbarasu

AU - Luciano, Michelle

AU - Macciardi, Fabio

AU - Machielsen, Marise W J

AU - MacQueen, Glenda M.

AU - Malt, Ulrik F.

AU - Mandl, René

AU - Manoach, Dara S.

AU - Martinot, Jean Luc

AU - Matarin, Mar

AU - Mather, Karen A.

AU - Mattheisen, Manuel

AU - Mattingsdal, Morten

AU - Meyer-Lindenberg, Andreas

AU - McDonald, Colm

AU - McIntosh, Andrew M.

AU - McMahon, Francis J.

AU - McMahon, Katie L.

AU - Meisenzahl, Eva

AU - Melle, Ingrid

AU - Milaneschi, Yuri

AU - Mohnke, Sebastian

AU - Montgomery, Grant W.

AU - Morris, Derek W.

AU - Moses, Eric K.

AU - Mueller, Bryon A.

AU - Muñoz Maniega, Susana

AU - Mühleisen, Thomas W.

AU - Müller-Myhsok, Bertram

AU - Mwangi, Benson

AU - Nauck, Matthias

AU - Nho, Kwangsik

AU - Nichols, Thomas E.

AU - Nilsson, Lars Göran

AU - Nugent, Allison C.

AU - Nyberg, Lars

AU - Olvera, Rene L.

AU - Oosterlaan, Jaap

AU - Ophoff, Roel A.

AU - Pandolfo, Massimo

AU - Papalampropoulou-Tsiridou, Melina

AU - Papmeyer, Martina

AU - Paus, Tomas

AU - Pausova, Zdenka

AU - Pearlson, Godfrey D.

AU - Penninx, Brenda W.

AU - Peterson, Charles P.

AU - Pfennig, Andrea

AU - Phillips, Mary

AU - Pike, G. Bruce

AU - Poline, Jean Baptiste

AU - Potkin, Steven G.

AU - Pütz, Benno

AU - Ramasamy, Adaikalavan

AU - Rasmussen, Jerod

AU - Rietschel, Marcella

AU - Rijpkema, Mark

AU - Risacher, Shannon L.

AU - Roffman, Joshua L.

AU - Roiz-Santiañez, Roberto

AU - Romanczuk-Seiferth, Nina

AU - Rose, Emma J.

AU - Royle, Natalie A.

AU - Rujescu, Dan

AU - Ryten, Mina

AU - Sachdev, Perminder S.

AU - Salami, Alireza

AU - Satterthwaite, Theodore D.

AU - Savitz, Jonathan

AU - Saykin, Andrew

AU - Scanlon, Cathy

AU - Schmaal, Lianne

AU - Schnack, Hugo G.

AU - Schork, Andrew J.

AU - Schulz, S. Charles

AU - Schür, Remmelt

AU - Seidman, Larry

AU - Shen, Li

AU - Shoemaker, Jody M.

AU - Simmons, Andrew

AU - Sisodiya, Sanjay M.

AU - Smith, Colin

AU - Smoller, Jordan W.

AU - Soares, Jair C.

AU - Sponheim, Scott R.

AU - Sprooten, Emma

AU - Starr, John M.

AU - Steen, Vidar M.

AU - Strakowski, Stephen

AU - Strike, Lachlan

AU - Sussmann, Jessika

AU - Sämann, Philipp G.

AU - Teumer, Alexander

AU - Toga, Arthur W.

AU - Tordesillas-Gutierrez, Diana

AU - Trabzuni, Daniah

AU - Trost, Sarah

AU - Turner, Jessica

AU - Van den Heuvel, Martijn

AU - van der Wee, Nic J.

AU - van Eijk, Kristel

AU - van Erp, Theo G M

AU - van Haren, Neeltje E M

AU - van 't Ent, Dennis

AU - van Tol, Marie Jose

AU - Valdés Hernández, Maria C.

AU - Veltman, Dick J.

AU - Versace, Amelia

AU - Völzke, Henry

AU - Walker, Robert

AU - Walter, Henrik

AU - Wang, Lei

AU - Wardlaw, Joanna M.

AU - Weale, Michael E.

AU - Weiner, Michael W.

AU - Wen, Wei

AU - Westlye, Lars T.

AU - Whalley, Heather C.

AU - Whelan, Christopher D.

AU - White, Tonya

AU - Winkler, Anderson M.

AU - Wittfeld, Katharina

AU - Woldehawariat, Girma

AU - Wolf, Christiane

AU - Zilles, David

AU - Zwiers, Marcel P.

AU - Thalamuthu, Anbupalam

AU - Schofield, Peter R.

AU - Freimer, Nelson B.

AU - Lawrence, Natalia S.

AU - Drevets, Wayne

PY - 2014

Y1 - 2014

N2 - The Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) Consortium is a collaborative network of researchers working together on a range of large-scale studies that integrate data from 70 institutions worldwide. Organized into Working Groups that tackle questions in neuroscience, genetics, and medicine, ENIGMA studies have analyzed neuroimaging data from over 12,826 subjects. In addition, data from 12,171 individuals were provided by the CHARGE consortium for replication of findings, in a total of 24,997 subjects. By meta-analyzing results from many sites, ENIGMA has detected factors that affect the brain that no individual site could detect on its own, and that require larger numbers of subjects than any individual neuroimaging study has currently collected. ENIGMA's first project was a genome-wide association study identifying common variants in the genome associated with hippocampal volume or intracranial volume. Continuing work is exploring genetic associations with subcortical volumes (ENIGMA2) and white matter microstructure (ENIGMA-DTI). Working groups also focus on understanding how schizophrenia, bipolar illness, major depression and attention deficit/hyperactivity disorder (ADHD) affect the brain. We review the current progress of the ENIGMA Consortium, along with challenges and unexpected discoveries made on the way.

AB - The Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) Consortium is a collaborative network of researchers working together on a range of large-scale studies that integrate data from 70 institutions worldwide. Organized into Working Groups that tackle questions in neuroscience, genetics, and medicine, ENIGMA studies have analyzed neuroimaging data from over 12,826 subjects. In addition, data from 12,171 individuals were provided by the CHARGE consortium for replication of findings, in a total of 24,997 subjects. By meta-analyzing results from many sites, ENIGMA has detected factors that affect the brain that no individual site could detect on its own, and that require larger numbers of subjects than any individual neuroimaging study has currently collected. ENIGMA's first project was a genome-wide association study identifying common variants in the genome associated with hippocampal volume or intracranial volume. Continuing work is exploring genetic associations with subcortical volumes (ENIGMA2) and white matter microstructure (ENIGMA-DTI). Working groups also focus on understanding how schizophrenia, bipolar illness, major depression and attention deficit/hyperactivity disorder (ADHD) affect the brain. We review the current progress of the ENIGMA Consortium, along with challenges and unexpected discoveries made on the way.

KW - Consortium

KW - Genetics

KW - GWAS

KW - Meta-analysis

KW - MRI

KW - Multi-site

UR - http://www.scopus.com/inward/record.url?scp=84899930958&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84899930958&partnerID=8YFLogxK

U2 - 10.1007/s11682-013-9269-5

DO - 10.1007/s11682-013-9269-5

M3 - Article

VL - 8

SP - 153

EP - 182

JO - Brain Imaging and Behavior

JF - Brain Imaging and Behavior

SN - 1931-7557

IS - 2

ER -