The ETS oncogene family in development, proliferation and neoplasia

R. Hromas, Michael Klemsz

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

V-ets was found as an oncogenic sequence in the E26 avian retrovirus, which produced leukemias in chickens. There are a large number of mammalian homologues of v-ets, all sharing a common sequence called the ETS domain. These mammalian homologues have been found to be transcriptional activators, and the ETS domain is the DNA binding portion of the gene. This family has been found to be important in regulating embryonic development and the response to growth stimuli. In addition, PU.1 and FLI-1 are dysregulated by Friend leukemia virus insertion in mice resulting in erythroleukemia. Significantly, the DNA binding portion of FLI-1 is the 3' part of an oncogenic fusion transcript (termed EWS-FLI) in human Ewing's sarcoma and neuroepithelioma.

Original languageEnglish
Pages (from-to)257-265
Number of pages9
JournalInternational Journal of Hematology
Volume59
Issue number4
StatePublished - 1994

Fingerprint

Oncogenes
Leukemia
Friend murine leukemia virus
Leukemia, Erythroblastic, Acute
Ewing's Sarcoma
DNA
Retroviridae
Embryonic Development
Chickens
Neoplasms
Growth
Genes
ETS Motif

Keywords

  • C-ETS
  • Ewing's sarcoma
  • Friend virus erythroleukemia
  • hematopoiesis
  • neuroepithelioma
  • oncogenes
  • transcription factors

ASJC Scopus subject areas

  • Hematology

Cite this

The ETS oncogene family in development, proliferation and neoplasia. / Hromas, R.; Klemsz, Michael.

In: International Journal of Hematology, Vol. 59, No. 4, 1994, p. 257-265.

Research output: Contribution to journalArticle

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