The expression of an alcohol deprivation effect in the high-alcohol- drinking replicate rat lines is dependent on repeated deprivations

Zachary Rodd, David L. McKinzie, James M. Murphy, William J. McBride, Lawrence Lumeng, Ting Kai Li

Research output: Contribution to journalArticle

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Abstract

Background: The alcohol deprivation effect (ADE) is a temporary increase in the ratio of alcohol/total fluid intake andy voluntary intake of ethanol (EtOH) solutions over baseline drinking conditions when EtOH access is reinstated after a period of alcohol deprivation. The ADE has been posited to be an animal model for alcohol craving. In the current study, we examined the effects of initial deprivation length and number of deprivation exposures on the ADE in the replicate lines of the high-alcohol-drinking (HAD) rats. Methods: Adult male HAD-1 and HAD-2 rats received 24 hr free-choice access to 10% (v/v) EtOH and water for 6 weeks. Rats were then assigned to groups deprived of EtOH for 0 (control), or 2 to 8 weeks. All deprived groups were then given 24 hr access to EtOH for 2 weeks before being deprived of EtOH for another 2 weeks. This cycle of 2 weeks of access and 2 weeks of deprivation was carried out for a total of four deprivations. Results: After the initial EtOH deprivation period, EtOH consumption in HAD-1 and HAD-2 rats returned to baseline levels but failed to exhibit either an early onset ADE (initial 2 hr) or prolonged ADE (24 hr). An ADE was observed in two of the four deprived groups for the HAD-1 rats (2 week and 6 week groups) and in all deprived groups for the HAD-2 rats after a second deprivation, and in all deprived groups of both lines after a third deprivation. In the HAD-2 line, but not in the HAD-1 line, the duration of the ADE was prolonged into the second reinstatement day after the fourth deprivation. Conclusions: The expression of an ADE was observed only after repeated deprivation periods in the HAD lines. The duration of the ADE was prolonged in the HAD-2 line, but not in the HAD-1 line, with repeated deprivations, which suggests a dissociation between selection for alcohol preference and the effects of repeated deprivations on the duration of the ADE.

Original languageEnglish
Pages (from-to)747-753
Number of pages7
JournalAlcoholism: Clinical and Experimental Research
Volume24
Issue number6
StatePublished - Jun 2000

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Alcohol Drinking
Rats
Alcohols
Drinking
Ethanol
Animal Models

Keywords

  • Alcohol Deprivation Effect
  • Alcohol Relapse
  • High-Alcohol-Drinking Rats

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Toxicology

Cite this

The expression of an alcohol deprivation effect in the high-alcohol- drinking replicate rat lines is dependent on repeated deprivations. / Rodd, Zachary; McKinzie, David L.; Murphy, James M.; McBride, William J.; Lumeng, Lawrence; Li, Ting Kai.

In: Alcoholism: Clinical and Experimental Research, Vol. 24, No. 6, 06.2000, p. 747-753.

Research output: Contribution to journalArticle

Rodd, Zachary ; McKinzie, David L. ; Murphy, James M. ; McBride, William J. ; Lumeng, Lawrence ; Li, Ting Kai. / The expression of an alcohol deprivation effect in the high-alcohol- drinking replicate rat lines is dependent on repeated deprivations. In: Alcoholism: Clinical and Experimental Research. 2000 ; Vol. 24, No. 6. pp. 747-753.
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T1 - The expression of an alcohol deprivation effect in the high-alcohol- drinking replicate rat lines is dependent on repeated deprivations

AU - Rodd, Zachary

AU - McKinzie, David L.

AU - Murphy, James M.

AU - McBride, William J.

AU - Lumeng, Lawrence

AU - Li, Ting Kai

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AB - Background: The alcohol deprivation effect (ADE) is a temporary increase in the ratio of alcohol/total fluid intake andy voluntary intake of ethanol (EtOH) solutions over baseline drinking conditions when EtOH access is reinstated after a period of alcohol deprivation. The ADE has been posited to be an animal model for alcohol craving. In the current study, we examined the effects of initial deprivation length and number of deprivation exposures on the ADE in the replicate lines of the high-alcohol-drinking (HAD) rats. Methods: Adult male HAD-1 and HAD-2 rats received 24 hr free-choice access to 10% (v/v) EtOH and water for 6 weeks. Rats were then assigned to groups deprived of EtOH for 0 (control), or 2 to 8 weeks. All deprived groups were then given 24 hr access to EtOH for 2 weeks before being deprived of EtOH for another 2 weeks. This cycle of 2 weeks of access and 2 weeks of deprivation was carried out for a total of four deprivations. Results: After the initial EtOH deprivation period, EtOH consumption in HAD-1 and HAD-2 rats returned to baseline levels but failed to exhibit either an early onset ADE (initial 2 hr) or prolonged ADE (24 hr). An ADE was observed in two of the four deprived groups for the HAD-1 rats (2 week and 6 week groups) and in all deprived groups for the HAD-2 rats after a second deprivation, and in all deprived groups of both lines after a third deprivation. In the HAD-2 line, but not in the HAD-1 line, the duration of the ADE was prolonged into the second reinstatement day after the fourth deprivation. Conclusions: The expression of an ADE was observed only after repeated deprivation periods in the HAD lines. The duration of the ADE was prolonged in the HAD-2 line, but not in the HAD-1 line, with repeated deprivations, which suggests a dissociation between selection for alcohol preference and the effects of repeated deprivations on the duration of the ADE.

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