The fate of synaptic membranes of degenerating optic nerve terminals, and their role in the mechanism of trans-synaptic changes

Henryk M. Wiśniewski, Bernardino Ghetti, Dikran S. Horoupian

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

The fate of synaptic membranes of degenerating optic nerve terminals has been studied in the lateral geniculate nucleus of Rhesus monkey after eye enucleation. It was shown that pre-synaptic and post-synaptic membranes remain in close apposition to each other during all stages of degeneration and phagocytosis of affected terminals. As a result of this, fragments of presynaptic terminals were engulfed within glial processes, together with synaptic thickenings and parts of post-synaptic dendrites. On occasion small pieces of the degenerating terminals together with the synaptic membranes were engulfed by the post-synaptic dendrite. It is proposed that this pattern of removal of degenerating optic terminals results in injury to the post-synaptic cells, and triggers the transneuronal degeneration.

Original languageEnglish (US)
Pages (from-to)297-310
Number of pages14
JournalJournal of Neurocytology
Volume1
Issue number3
DOIs
StatePublished - Oct 1 1972
Externally publishedYes

Keywords

  • Lateral geniculate nucleus
  • optic nerve terminals
  • phagocytosis
  • post-synaptic dendrite
  • synaptic membranes
  • trans-synaptic degeneration

ASJC Scopus subject areas

  • Anatomy
  • Neuroscience(all)
  • Histology
  • Cell Biology

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