The fate of the axon and its terminal in the Pacinian corpuscle following sciatic nerve section

Jan K. Korthals, Henryk M. Wisniewski, Bernardino Ghetti, Robert D. Cook

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Central nerve fibres of Pacinian corpuscles of the cat were examined by semiserial sections 2, 3, 4, 5, 6 and 9 days after sciatic nerve cut. Axons of the Pacinian corpuscles showed degenerative changes 4 days after transsection and the removal of axonal and myelin debris was almost completed within 9 days. Axonal degeneration was characterized by disintegration of filaments and tubules, disruption of axolemma, swelling of mitochondria and loss of filopod processes in the terminal axon. Selective preservation of filaments in local areas of terminal axons was found in some corpuscles. The myelinated portions of the nerve fibre were removed by Schwann cells and the unmyelinated terminal portions by inner core lamellar cells. Mitochondria and other degenerated axoplasmic organelles of the terminal axon formed dense bodies following their engulfment by lamellar cells. The unmyelinated portion of the axon was removed faster than the myelinated. The rate of removal of axonal debris varied along the length of both the unmyelinated and myelinated portions of the nerve fibre. Similarity in the behaviour and morphology of reactive lamellar and Schwann cells points to the possibility of the common derivation of these cells.

Original languageEnglish (US)
Pages (from-to)385-403
Number of pages19
JournalJournal of Neurocytology
Volume3
Issue number3
DOIs
StatePublished - Aug 1 1974

Fingerprint

Pacinian Corpuscles
Presynaptic Terminals
Sciatic Nerve
Myelinated Nerve Fibers
Schwann Cells
Axons
Mitochondria
Myelin Sheath
Nerve Fibers
Organelles
Cats

ASJC Scopus subject areas

  • Anatomy
  • Neuroscience(all)
  • Histology
  • Cell Biology

Cite this

The fate of the axon and its terminal in the Pacinian corpuscle following sciatic nerve section. / Korthals, Jan K.; Wisniewski, Henryk M.; Ghetti, Bernardino; Cook, Robert D.

In: Journal of Neurocytology, Vol. 3, No. 3, 01.08.1974, p. 385-403.

Research output: Contribution to journalArticle

Korthals, Jan K. ; Wisniewski, Henryk M. ; Ghetti, Bernardino ; Cook, Robert D. / The fate of the axon and its terminal in the Pacinian corpuscle following sciatic nerve section. In: Journal of Neurocytology. 1974 ; Vol. 3, No. 3. pp. 385-403.
@article{deef2573719e46d2a528da829c5309a2,
title = "The fate of the axon and its terminal in the Pacinian corpuscle following sciatic nerve section",
abstract = "Central nerve fibres of Pacinian corpuscles of the cat were examined by semiserial sections 2, 3, 4, 5, 6 and 9 days after sciatic nerve cut. Axons of the Pacinian corpuscles showed degenerative changes 4 days after transsection and the removal of axonal and myelin debris was almost completed within 9 days. Axonal degeneration was characterized by disintegration of filaments and tubules, disruption of axolemma, swelling of mitochondria and loss of filopod processes in the terminal axon. Selective preservation of filaments in local areas of terminal axons was found in some corpuscles. The myelinated portions of the nerve fibre were removed by Schwann cells and the unmyelinated terminal portions by inner core lamellar cells. Mitochondria and other degenerated axoplasmic organelles of the terminal axon formed dense bodies following their engulfment by lamellar cells. The unmyelinated portion of the axon was removed faster than the myelinated. The rate of removal of axonal debris varied along the length of both the unmyelinated and myelinated portions of the nerve fibre. Similarity in the behaviour and morphology of reactive lamellar and Schwann cells points to the possibility of the common derivation of these cells.",
author = "Korthals, {Jan K.} and Wisniewski, {Henryk M.} and Bernardino Ghetti and Cook, {Robert D.}",
year = "1974",
month = "8",
day = "1",
doi = "10.1007/BF01097920",
language = "English (US)",
volume = "3",
pages = "385--403",
journal = "Journal of Neurocytology",
issn = "0300-4864",
publisher = "Kluwer Academic Publishers",
number = "3",

}

TY - JOUR

T1 - The fate of the axon and its terminal in the Pacinian corpuscle following sciatic nerve section

AU - Korthals, Jan K.

AU - Wisniewski, Henryk M.

AU - Ghetti, Bernardino

AU - Cook, Robert D.

PY - 1974/8/1

Y1 - 1974/8/1

N2 - Central nerve fibres of Pacinian corpuscles of the cat were examined by semiserial sections 2, 3, 4, 5, 6 and 9 days after sciatic nerve cut. Axons of the Pacinian corpuscles showed degenerative changes 4 days after transsection and the removal of axonal and myelin debris was almost completed within 9 days. Axonal degeneration was characterized by disintegration of filaments and tubules, disruption of axolemma, swelling of mitochondria and loss of filopod processes in the terminal axon. Selective preservation of filaments in local areas of terminal axons was found in some corpuscles. The myelinated portions of the nerve fibre were removed by Schwann cells and the unmyelinated terminal portions by inner core lamellar cells. Mitochondria and other degenerated axoplasmic organelles of the terminal axon formed dense bodies following their engulfment by lamellar cells. The unmyelinated portion of the axon was removed faster than the myelinated. The rate of removal of axonal debris varied along the length of both the unmyelinated and myelinated portions of the nerve fibre. Similarity in the behaviour and morphology of reactive lamellar and Schwann cells points to the possibility of the common derivation of these cells.

AB - Central nerve fibres of Pacinian corpuscles of the cat were examined by semiserial sections 2, 3, 4, 5, 6 and 9 days after sciatic nerve cut. Axons of the Pacinian corpuscles showed degenerative changes 4 days after transsection and the removal of axonal and myelin debris was almost completed within 9 days. Axonal degeneration was characterized by disintegration of filaments and tubules, disruption of axolemma, swelling of mitochondria and loss of filopod processes in the terminal axon. Selective preservation of filaments in local areas of terminal axons was found in some corpuscles. The myelinated portions of the nerve fibre were removed by Schwann cells and the unmyelinated terminal portions by inner core lamellar cells. Mitochondria and other degenerated axoplasmic organelles of the terminal axon formed dense bodies following their engulfment by lamellar cells. The unmyelinated portion of the axon was removed faster than the myelinated. The rate of removal of axonal debris varied along the length of both the unmyelinated and myelinated portions of the nerve fibre. Similarity in the behaviour and morphology of reactive lamellar and Schwann cells points to the possibility of the common derivation of these cells.

UR - http://www.scopus.com/inward/record.url?scp=0016235527&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0016235527&partnerID=8YFLogxK

U2 - 10.1007/BF01097920

DO - 10.1007/BF01097920

M3 - Article

C2 - 4373544

AN - SCOPUS:0016235527

VL - 3

SP - 385

EP - 403

JO - Journal of Neurocytology

JF - Journal of Neurocytology

SN - 0300-4864

IS - 3

ER -