The Fate of the Ovaries after Radical Hysterectomy and Ovarian Transposition

Daniel D. Feeney, David H. Moore, Katherine Y. Look, Frederick Stehman, Gregory P. Sutton

Research output: Contribution to journalArticle

89 Citations (Scopus)

Abstract

To assess the effectiveness of lateral ovarian transposition in preserving normal ovarian function, the medical records of 200 consecutive women with stage I-IIA cervical cancer treated primarily with radical hysterectomy and pelvic lymphadenectomy were reviewed. Lateral ovarian transposition was performed at the time of radical hysterectomy in 132 (66%) patients and 28 (21%) received postoperative pelvic radiation therapy. Menopausal symptoms (vaginal dryness, hot flushes) and follicle-stimulating hormone (FSH) levels were used to define ovarian function. Only 3/104 (2.9%) patients who underwent lateral ovarian transposition without postoperative pelvic radiotherapy experienced menopausal symptoms; however, FSH levels in all three cases suggested continued ovarian function. In 14/28 (50%) patients who received postoperative pelvic radiation therapy ovarian failure occurred. The risk of ovarian failure with pelvic radiation therapy after lateral ovarian transposition was significant (RR = 17.3; 95% CI = 5.35-56.13). The incidence of adnexal disease in transposed ovaries requiring analgesics or further surgery was 3%. These data suggest minimal risk to the patient when the ovaries are conserved. Unfortunately, lateral ovarian transposition preserves ovarian function in only 50% of patients undergoing pelvic radiotherapy following radical hysterectomy.

Original languageEnglish
Pages (from-to)3-7
Number of pages5
JournalGynecologic Oncology
Volume56
Issue number1
DOIs
StatePublished - Jan 1995

Fingerprint

Hysterectomy
Ovary
Radiotherapy
Follicle Stimulating Hormone
Adnexal Diseases
Lymph Node Excision
Uterine Cervical Neoplasms
Medical Records
Analgesics
Incidence

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynecology

Cite this

The Fate of the Ovaries after Radical Hysterectomy and Ovarian Transposition. / Feeney, Daniel D.; Moore, David H.; Look, Katherine Y.; Stehman, Frederick; Sutton, Gregory P.

In: Gynecologic Oncology, Vol. 56, No. 1, 01.1995, p. 3-7.

Research output: Contribution to journalArticle

Feeney, Daniel D. ; Moore, David H. ; Look, Katherine Y. ; Stehman, Frederick ; Sutton, Gregory P. / The Fate of the Ovaries after Radical Hysterectomy and Ovarian Transposition. In: Gynecologic Oncology. 1995 ; Vol. 56, No. 1. pp. 3-7.
@article{b821272cc8934894800195fb9013749a,
title = "The Fate of the Ovaries after Radical Hysterectomy and Ovarian Transposition",
abstract = "To assess the effectiveness of lateral ovarian transposition in preserving normal ovarian function, the medical records of 200 consecutive women with stage I-IIA cervical cancer treated primarily with radical hysterectomy and pelvic lymphadenectomy were reviewed. Lateral ovarian transposition was performed at the time of radical hysterectomy in 132 (66{\%}) patients and 28 (21{\%}) received postoperative pelvic radiation therapy. Menopausal symptoms (vaginal dryness, hot flushes) and follicle-stimulating hormone (FSH) levels were used to define ovarian function. Only 3/104 (2.9{\%}) patients who underwent lateral ovarian transposition without postoperative pelvic radiotherapy experienced menopausal symptoms; however, FSH levels in all three cases suggested continued ovarian function. In 14/28 (50{\%}) patients who received postoperative pelvic radiation therapy ovarian failure occurred. The risk of ovarian failure with pelvic radiation therapy after lateral ovarian transposition was significant (RR = 17.3; 95{\%} CI = 5.35-56.13). The incidence of adnexal disease in transposed ovaries requiring analgesics or further surgery was 3{\%}. These data suggest minimal risk to the patient when the ovaries are conserved. Unfortunately, lateral ovarian transposition preserves ovarian function in only 50{\%} of patients undergoing pelvic radiotherapy following radical hysterectomy.",
author = "Feeney, {Daniel D.} and Moore, {David H.} and Look, {Katherine Y.} and Frederick Stehman and Sutton, {Gregory P.}",
year = "1995",
month = "1",
doi = "10.1006/gyno.1995.1002",
language = "English",
volume = "56",
pages = "3--7",
journal = "Gynecologic Oncology",
issn = "0090-8258",
publisher = "Academic Press Inc.",
number = "1",

}

TY - JOUR

T1 - The Fate of the Ovaries after Radical Hysterectomy and Ovarian Transposition

AU - Feeney, Daniel D.

AU - Moore, David H.

AU - Look, Katherine Y.

AU - Stehman, Frederick

AU - Sutton, Gregory P.

PY - 1995/1

Y1 - 1995/1

N2 - To assess the effectiveness of lateral ovarian transposition in preserving normal ovarian function, the medical records of 200 consecutive women with stage I-IIA cervical cancer treated primarily with radical hysterectomy and pelvic lymphadenectomy were reviewed. Lateral ovarian transposition was performed at the time of radical hysterectomy in 132 (66%) patients and 28 (21%) received postoperative pelvic radiation therapy. Menopausal symptoms (vaginal dryness, hot flushes) and follicle-stimulating hormone (FSH) levels were used to define ovarian function. Only 3/104 (2.9%) patients who underwent lateral ovarian transposition without postoperative pelvic radiotherapy experienced menopausal symptoms; however, FSH levels in all three cases suggested continued ovarian function. In 14/28 (50%) patients who received postoperative pelvic radiation therapy ovarian failure occurred. The risk of ovarian failure with pelvic radiation therapy after lateral ovarian transposition was significant (RR = 17.3; 95% CI = 5.35-56.13). The incidence of adnexal disease in transposed ovaries requiring analgesics or further surgery was 3%. These data suggest minimal risk to the patient when the ovaries are conserved. Unfortunately, lateral ovarian transposition preserves ovarian function in only 50% of patients undergoing pelvic radiotherapy following radical hysterectomy.

AB - To assess the effectiveness of lateral ovarian transposition in preserving normal ovarian function, the medical records of 200 consecutive women with stage I-IIA cervical cancer treated primarily with radical hysterectomy and pelvic lymphadenectomy were reviewed. Lateral ovarian transposition was performed at the time of radical hysterectomy in 132 (66%) patients and 28 (21%) received postoperative pelvic radiation therapy. Menopausal symptoms (vaginal dryness, hot flushes) and follicle-stimulating hormone (FSH) levels were used to define ovarian function. Only 3/104 (2.9%) patients who underwent lateral ovarian transposition without postoperative pelvic radiotherapy experienced menopausal symptoms; however, FSH levels in all three cases suggested continued ovarian function. In 14/28 (50%) patients who received postoperative pelvic radiation therapy ovarian failure occurred. The risk of ovarian failure with pelvic radiation therapy after lateral ovarian transposition was significant (RR = 17.3; 95% CI = 5.35-56.13). The incidence of adnexal disease in transposed ovaries requiring analgesics or further surgery was 3%. These data suggest minimal risk to the patient when the ovaries are conserved. Unfortunately, lateral ovarian transposition preserves ovarian function in only 50% of patients undergoing pelvic radiotherapy following radical hysterectomy.

UR - http://www.scopus.com/inward/record.url?scp=0028928741&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028928741&partnerID=8YFLogxK

U2 - 10.1006/gyno.1995.1002

DO - 10.1006/gyno.1995.1002

M3 - Article

VL - 56

SP - 3

EP - 7

JO - Gynecologic Oncology

JF - Gynecologic Oncology

SN - 0090-8258

IS - 1

ER -