The first synthesis of [11C]J147, a new potential PET agent for imaging of Alzheimer's disease

Min Wang, Mingzhang Gao, Qi Huang Zheng

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

J147 was synthesized from 2,4-dimethylphenylhydrazine hydrochloride and 3-methoxybenzaldehyde in 2 steps with 71% overall yield. The precursor desmethyl-J147 was synthesized from 3-hydroxybenzaldehyde and 2,4-dimethylphenylhydrazine hydrochloride in 4 steps with 63% overall yield. [11C]J147 was prepared from desmethyl-J147 with [11C] CH3OTf through O-[11C]methylation and isolated by HPLC combined with solid-phase extraction (SPE) in 35-50% radiochemical yield based on [11C]CO2 and decay corrected to end of bombardment (EOB), with 370-740 GBq/μmol specific activity at EOB.

Original languageEnglish (US)
Pages (from-to)524-527
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume23
Issue number2
DOIs
StatePublished - Jan 15 2013

Keywords

  • [C]J147
  • Alzheimer's disease (AD)
  • Automation
  • Brain imaging
  • Positron emission tomography (PET)
  • Radiosynthesis

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Drug Discovery
  • Organic Chemistry
  • Molecular Medicine
  • Molecular Biology
  • Clinical Biochemistry
  • Biochemistry
  • Medicine(all)

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