The first synthesis of the antiangiogenic homoisoflavanone, cremastranone

Bit Lee, Halesha D. Basavarajappa, Rania S. Sulaiman, Xiang Fei, Seung Yong Seo, Timothy Corson

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

An antiangiogenic homoisoflavanone, cremastranone, was synthesized for the first time. This scalable synthesis, which includes selective demethylation, could be used to develop lead molecules to treat angiogenesis-induced eye diseases. Synthetic cremastranone inhibited the proliferation, migration and tube formation ability of human retinal microvascular endothelial cells, important steps in pathological angiogenesis.

Original languageEnglish
Pages (from-to)7673-7677
Number of pages5
JournalOrganic and Biomolecular Chemistry
Volume12
Issue number39
DOIs
StatePublished - Oct 21 2014

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angiogenesis
eye diseases
Pathologic Neovascularization
Eye Diseases
Endothelial cells
synthesis
Endothelial Cells
tubes
Molecules
molecules
5,7-dihydroxy-3-(3-hydroxy-4-methoxybenzyl)-6-methoxychroman-4-one

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Biochemistry
  • Medicine(all)

Cite this

The first synthesis of the antiangiogenic homoisoflavanone, cremastranone. / Lee, Bit; Basavarajappa, Halesha D.; Sulaiman, Rania S.; Fei, Xiang; Seo, Seung Yong; Corson, Timothy.

In: Organic and Biomolecular Chemistry, Vol. 12, No. 39, 21.10.2014, p. 7673-7677.

Research output: Contribution to journalArticle

Lee, Bit ; Basavarajappa, Halesha D. ; Sulaiman, Rania S. ; Fei, Xiang ; Seo, Seung Yong ; Corson, Timothy. / The first synthesis of the antiangiogenic homoisoflavanone, cremastranone. In: Organic and Biomolecular Chemistry. 2014 ; Vol. 12, No. 39. pp. 7673-7677.
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