The first synthesis of the antiangiogenic homoisoflavanone, cremastranone

Bit Lee, Halesha D. Basavarajappa, Rania S. Sulaiman, Xiang Fei, Seung Yong Seo, Timothy W. Corson

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

An antiangiogenic homoisoflavanone, cremastranone, was synthesized for the first time. This scalable synthesis, which includes selective demethylation, could be used to develop lead molecules to treat angiogenesis-induced eye diseases. Synthetic cremastranone inhibited the proliferation, migration and tube formation ability of human retinal microvascular endothelial cells, important steps in pathological angiogenesis.

Original languageEnglish (US)
Pages (from-to)7673-7677
Number of pages5
JournalOrganic and Biomolecular Chemistry
Volume12
Issue number39
DOIs
StatePublished - Oct 21 2014

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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